Aberrant resting-state functional connectivity underlies cognitive and functional impairments in remitted patients with bipolar disorder
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Aberrant resting-state functional connectivity underlies cognitive and functional impairments in remitted patients with bipolar disorder. / Fortea, Lydia; Ysbæk-Nielsen, Alexander T.; Macoveanu, Julian; Petersen, Jeff Zarp; Fisher, Patrick M.; Kessing, Lars V.; Knudsen, Gitte M.; Radua, Joaquim; Vieta, Eduard; Miskowiak, Kamilla W.
I: Acta Psychiatrica Scandinavica, Bind 148, Nr. 6, 2023, s. 570-582.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Aberrant resting-state functional connectivity underlies cognitive and functional impairments in remitted patients with bipolar disorder
AU - Fortea, Lydia
AU - Ysbæk-Nielsen, Alexander T.
AU - Macoveanu, Julian
AU - Petersen, Jeff Zarp
AU - Fisher, Patrick M.
AU - Kessing, Lars V.
AU - Knudsen, Gitte M.
AU - Radua, Joaquim
AU - Vieta, Eduard
AU - Miskowiak, Kamilla W.
N1 - Publisher Copyright: © 2023 The Authors. Acta Psychiatrica Scandinavica published by John Wiley & Sons Ltd.
PY - 2023
Y1 - 2023
N2 - Background: Bipolar disorder (BD) is commonly associated with cognitive impairments, that directly contribute to patients' functional disability. However, there is no effective treatment targeting cognition in BD. A key reason for the lack of pro-cognitive interventions is the limited insight into the brain correlates of cognitive impairments in these patients. This is the first study investigating the resting-state neural underpinnings of cognitive impairments in different neurocognitive subgroups of patients with BD. Method: Patients with BD in full or partial remission and healthy controls (final sample of n = 144 and n = 50, respectively) underwent neuropsychological assessment and resting-state functional magnetic resonance imaging. We classified the patients into cognitively impaired (n = 83) and cognitively normal (n = 61) subgroups using hierarchical cluster analysis of the four cognitive domains. We used independent component analysis (ICA) to investigate the differences between the neurocognitive subgroups and healthy controls in resting-state functional connectivity (rsFC) in the default mode network (DMN), executive central network (ECN), and frontoparietal network (FPN). Results: Cognitively impaired patients displayed greater positive rsFC within the DMN and less negative rsFC within the ECN than healthy controls. Across cognitively impaired patients, lower positive connectivity within DMN and lower negative rsFC within ECN correlated with worse global cognitive performance. Conclusion: Cognitive impairments in BD seem to be associated with a hyper-connectivity within the DMN, which may explain the failure to suppress task-irrelevant DMN activity during the cognitive performance, and blunted anticorrelation in the ECN. Thus, aberrant connectivity within the DMN and ECN may serve as brain targets for pro-cognitive interventions.
AB - Background: Bipolar disorder (BD) is commonly associated with cognitive impairments, that directly contribute to patients' functional disability. However, there is no effective treatment targeting cognition in BD. A key reason for the lack of pro-cognitive interventions is the limited insight into the brain correlates of cognitive impairments in these patients. This is the first study investigating the resting-state neural underpinnings of cognitive impairments in different neurocognitive subgroups of patients with BD. Method: Patients with BD in full or partial remission and healthy controls (final sample of n = 144 and n = 50, respectively) underwent neuropsychological assessment and resting-state functional magnetic resonance imaging. We classified the patients into cognitively impaired (n = 83) and cognitively normal (n = 61) subgroups using hierarchical cluster analysis of the four cognitive domains. We used independent component analysis (ICA) to investigate the differences between the neurocognitive subgroups and healthy controls in resting-state functional connectivity (rsFC) in the default mode network (DMN), executive central network (ECN), and frontoparietal network (FPN). Results: Cognitively impaired patients displayed greater positive rsFC within the DMN and less negative rsFC within the ECN than healthy controls. Across cognitively impaired patients, lower positive connectivity within DMN and lower negative rsFC within ECN correlated with worse global cognitive performance. Conclusion: Cognitive impairments in BD seem to be associated with a hyper-connectivity within the DMN, which may explain the failure to suppress task-irrelevant DMN activity during the cognitive performance, and blunted anticorrelation in the ECN. Thus, aberrant connectivity within the DMN and ECN may serve as brain targets for pro-cognitive interventions.
KW - bipolar disorder
KW - cognitive impairments
KW - functional connectivity
KW - psychological functioning
KW - resting-state fMRI
U2 - 10.1111/acps.13615
DO - 10.1111/acps.13615
M3 - Journal article
C2 - 37688285
AN - SCOPUS:85170540866
VL - 148
SP - 570
EP - 582
JO - Acta Psychiatrica Scandinavica
JF - Acta Psychiatrica Scandinavica
SN - 0001-690X
IS - 6
ER -
ID: 368334643