A coalescence approach to gene conversion
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A coalescence approach to gene conversion. / Wiuf, Carsten.
I: Theoretical Population Biology, Bind 57, Nr. 4, 01.01.2000, s. 357-367.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - A coalescence approach to gene conversion
AU - Wiuf, Carsten
PY - 2000/1/1
Y1 - 2000/1/1
N2 - In this paper we develop a coalescent model with intralocus gene conversion. Such models are of increasing importance in the analysis of intralocus variability and linkage disequilibrium. We derive the distribution of the waiting time until a gene conversion event occurs in a sample in terms of the distribution of the length of the transferred segment, ζ. We do not assume any specific form of the distribution of ζ. Further, given that a gene conversion event occurs we find the distribution of (σ, τ), the end points of the transferred segment and derive results on correlations between local trees in positions X1 and X1. Among other results we show that the correlation between the branch lengths of two local trees in the coalescent with gene conversion (and no recombination) decreases toward a nonzero constant when the distance between X1 and X1 increases. Finally, we show that a model including both recombination and gene conversion might account for the lack of intralocus associations found in, e.g., Drosophila melanogaster. (C) 2000 Academic Press.
AB - In this paper we develop a coalescent model with intralocus gene conversion. Such models are of increasing importance in the analysis of intralocus variability and linkage disequilibrium. We derive the distribution of the waiting time until a gene conversion event occurs in a sample in terms of the distribution of the length of the transferred segment, ζ. We do not assume any specific form of the distribution of ζ. Further, given that a gene conversion event occurs we find the distribution of (σ, τ), the end points of the transferred segment and derive results on correlations between local trees in positions X1 and X1. Among other results we show that the correlation between the branch lengths of two local trees in the coalescent with gene conversion (and no recombination) decreases toward a nonzero constant when the distance between X1 and X1 increases. Finally, we show that a model including both recombination and gene conversion might account for the lack of intralocus associations found in, e.g., Drosophila melanogaster. (C) 2000 Academic Press.
KW - Coalescent model
KW - Gene conversion
KW - Intralocus variability
KW - Linkage disequilibrium
KW - Recombination
UR - http://www.scopus.com/inward/record.url?scp=0033907068&partnerID=8YFLogxK
U2 - 10.1006/tpbi.2000.1462
DO - 10.1006/tpbi.2000.1462
M3 - Journal article
C2 - 10900188
AN - SCOPUS:0033907068
VL - 57
SP - 357
EP - 367
JO - Theoretical Population Biology
JF - Theoretical Population Biology
SN - 0040-5809
IS - 4
ER -
ID: 203901637