Rasmus Hartmann-Petersen
Professor
Biomolecular Sciences
Ole Maaløes Vej 5
2200 København N.
Undervisnings- og vejledningsområder
I teach on the following courses:
Gene technology (lectures, seminars, practicals), Protein Chemistry and Enzymology (lectures, practicals), Protein Science (lectures, seminars).
I supervise students on projects related to:
Protein Chemistry, Molecular Biology, Cell Biology & Genetics.
Interesseområder
Intracellular protein degradation, the 26S proteasome, the ubiquitin system, cellular redox control, protein folding, molecular chaperones, protein quality control, degrons, genetic diseases, variant classification.
Aktuel forskning
Our research activity is primarily centered on intracellular protein degradation via the ubiquitin-proteasome pathway. The ubiquitin-proteasome system is highly conserved and is the major pathway for intracellular proteolysis in all eukaryotic cells. Accordingly, ubiquitin-dependent protein degradation plays a pivotal role in the turnover of key regulatory proteins involved in a series of cellular processes, including cell cycle control, signal transduction, and protein folding. For a number of years a focus area for us has been how abnormal or misfolded proteins are targeted for degradation. To this end, we focus on genetic disorders and use yeast and mammalian cells in tissue culture as model systems, combined with a series of genetic, biochemical and molecular cell biological methods. In addition, we collaborate closely with a number of other research groups both in Denmark and abroad.
ID: 11839
Flest downloads
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1960
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HUWE1 and TRIP12 Collaborate in Degradation of Ubiquitin-Fusion Proteins and Misframed Ubiquitin
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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1115
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Single site suppressors of a fission yeast temperature-sensitive mutant in cdc48 identified by whole genome sequencing
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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862
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A chaperone-assisted degradation pathway targets kinetochore proteins to ensure genome stability
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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