Özcan Met
Gæstelektor
Immunology
Blegdamsvej 3B
2200 København N.
Medlem af:
Primære forskningsområder
My current research focus is in the area of molecular and cellular tumor immunology, particularly the development of gene-engineered T cells, tailored to treat cancer:
(1) engineering of T cells with tumor-specific synthetic TCRs or chimeric antigen receptors (CARs) for adoptive immunotherapy (ACT)
(2) manipulate co-stimulatory pathways to improve expansion of tumor-resident tumor-infiltrating lymphocytes (TILs) enriched for tumor specificity
(3) genome editing using CRISPR/Cas9 to target cell-intrinsic pathways that restrict T-cell effector functions and their anti-tumor potential
(4) Development of isolation and expansion methods for TIL therapy and to produce large-scale GMP-grade TIL products for ACT clinical trials of melanoma and other solid tumors
ID: 33971757
Flest downloads
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267
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T cell recognition of novel shared breast cancer antigens is frequently observed in peripheral blood of breast cancer patients
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142
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Improved migration of tumor ascites lymphocytes to ovarian cancer microenvironment by CXCR2 transduction
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128
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The metabolic enzyme arginase-2 is a potential target for novel immune modulatory vaccines
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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