Kei Sakamoto

Kei Sakamoto

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    1. Protor-1 is required for efticient mT0RC2-mediated activation of SGK1 in the kidney

      Pearce, L. R., Sommer, E. M., Sakamoto, Kei, Wullschleger, S. & Alessi, D. R., 15 May 2011, In: Biochemical Journal. 436, 1, p. 169-179 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      PEN2: Metformin’s new partner at lysosome

      Sakamoto, Kei & Jessen, N., 2022, In: Cell Research. 32, p. 507-508

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Overexpression or ablation of JNK in skeletal muscle has no effect on glycogen synthase activity

      Fujii, N., Boppart, M. D., Dufresne, S. D., Crowley, P. F., Jozsi, A. C., Sakamoto, Kei, Yu, H., Aschenbach, W. G., Kim, S., Miyazaki, H., Rui, L., White, M. F., Hirshman, M. F. & Goodyear, L. J., 1 Jul 2004, In: American Journal of Physiology - Cell Physiology. 287, 1 56-1, p. C200-C208

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Opposing effects on regulated insulin secretion of acute vs chronic stimulation of AMP-activated protein kinase

      Nguyen-Tu, M., Harris, J., Martinez-Sanchez, A., Chabosseau, P., Hu, M., Georgiadou, E., Pollard, A., Otero, P., Lopez-Noriega, L., Leclerc, I., Sakamoto, Kei, Schmoll, D., Smith, D. M., Carling, D. & Rutter, G. A., 2022, In: Diabetologia. 65, p. 997-1011 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Natural (dihydro)phenanthrene plant compounds are direct activators of AMPK through its allosteric drug and metabolite–binding site

      Sanders, M. J., Ratinaud, Y., Neopane, K., Bonhoure, N., Day, E. A., Ciclet, O., Lassueur, S., Pinta, M. N., Deak, M., Brinon, B., Christen, S., Steinberg, G. R., Barron, D. & Sakamoto, Kei, 2022, In: Journal of Biological Chemistry. 298, 5, 15 p., 101852.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance

      Bayascas, J. R., Wullschleger, S., Sakamoto, Kei, García-Martínez, J. M., Clacher, C., Komander, D., Van Aalten, D. M. F., Boini, K. M., Lang, F., Lipina, C., Logie, L., Sutherland, C., Chudek, J. A., Van Diepen, J. A., Voshol, P. J., Lucocq, J. M. & Alessi, D. R., May 2008, In: Molecular and Cellular Biology. 28, 10, p. 3258-3272 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Mutation in the γ2-Subunit of AMP-activated protein kinase stimulates cardiomyocyte proliferation and hypertrophy independent of glycogen storage

      Kim, M., Hunter, R. W., Garcia-Menendez, L., Gong, G., Yang, Y. Y., Kolwicz, S. C., Xu, J., Sakamoto, Kei, Wang, W. & Tian, R., 14 Mar 2014, In: Circulation Research. 114, 6, p. 966-975 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism

      Patra, K. C., Kato, Y., Mizukami, Y., Widholz, S., Boukhali, M., Revenco, I., Grossman, E. A., Ji, F., Sadreyev, R. I., Liss, A. S., Screaton, R. A., Sakamoto, Kei, Ryan, D. P., Mino-Kenudson, M., Castillo, C. F. D., Nomura, D. K., Haas, W. & Bardeesy, N., 1 Jul 2018, In: Nature Cell Biology. 20, 7, p. 811-822 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: Identification of mitochondrial fission factor as a new AMPK substrate

      Ducommun, S., Deak, M., Sumpton, D., Ford, R. J., Núñez Galindo, A., Kussmann, M., Viollet, B., Steinberg, G. R., Foretz, M., Dayon, L., Morrice, N. A. & Sakamoto, Kei, 1 May 2015, In: Cellular Signalling. 27, 5, p. 978-988 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Molecular mechanism of action of metformin: Old or new insights?

      Rena, G., Pearson, E. R. & Sakamoto, Kei, 1 Sep 2013, In: Diabetologia. 56, 9, p. 1898-1906 9 p.

      Research output: Contribution to journal › Review › Research › peer-review

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