Anne-Vibeke Lænkholm

Anne-Vibeke Lænkholm

Clinical Associate Professor


  1. 2018
  2. Published

    Clinical and molecular characterization of BRCA-associated breast cancer: results from the DBCG

    Soenderstrup, I. M. H., Lænkholm, Anne-Vibeke, Jensen, M. B., Eriksen, J. O., Gerdes, Anne-Marie Axø, Hansen, T. V. O., Kruse, T. A., Larsen, M. J., Pedersen, I. S., Rossing, M., Thomassen, M. & Ejlertsen, B., 2018, In: Acta Oncologica. 57, 1, p. 95-101

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Standardized assessment of tumor-infiltrating lymphocytes in breast cancer: an evaluation of inter-observer agreement between pathologists

    Tramm, T., Di Caterino, T., Jylling, A. M. B., Lelkaitis, G., Lænkholm, Anne-Vibeke, Ragó, P., Tabor, T. P., Talman, M. L. M., Vouza, E. & On behalf of the Scientific Committee of Pathology, Danish Breast Cancer Group (DBCG), O. B. O. T. S. C. O. P. D. B. C. G. (., 2018, In: Acta Oncologica. 57, 1, p. 90-94

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. 2017
  5. Published

    Application of automated image analysis reduces the workload of manual screening of sentinel lymph node biopsies in breast cancer

    Holten-Rossing, H., Talman, M. M., Jylling, A. M. B., Lænkholm, Anne-Vibeke, Kristensson, M. & Vainer, B., Dec 2017, In: Histopathology. 71, 6, p. 866-873

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Genomic Analyses of Breast Cancer Progression Reveal Distinct Routes of Metastasis Emergence

    Krøigård, A. B., Larsen, M. J., Brasch-Andersen, C., Lænkholm, Anne-Vibeke, Knoop, A. S., Jensen, J. D., Bak, M., Mollenhauer, J., Thomassen, M. & Kruse, T. A., 2017, In: Scientific Reports. 7, 9 p., 43813.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

    Milne, R. L., Kuchenbaecker, K. B., Michailidou, K., Beesley, J., Kar, S., Lindström, S., Hui, S., Lemaçon, A., Soucy, P., Dennis, J., Jiang, X., Rostamianfar, A., Finucane, H., Bolla, M. K., McGuffog, L., Wang, Q., Aalfs, C. M., ABCTB Investigators, Adams, M., Adlard, J. & 27 others, Agata, S., Ahmed, S., Ahsan, H., Aittomäki, K., Al-Ejeh, F., Allen, J., Ambrosone, C. B., Amos, C. I., Andrulis, I. L., Anton-Culver, H., Antonenkova, N. N., Arndt, V., Arnold, N., Aronson, K. J., Auber, B., Auer, P. L., Ausems, M. G. E. M., Azzollini, J., Bacot, F., Balmaña, J., Bojesen, Stig Egil, Gerdes, Anne-Marie Axø, Lænkholm, Anne-Vibeke, Nordestgaard, Børge, Schmidt, M. K., Antoniou, A. C. & Simard, J., 2017, In: Nature Genetics. 49, 12, p. 1767-1778

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. 2016
  9. Published

    Prognostic impact of tumor MET expression among patients with stage IV gastric cancer: a Danish cohort study

    Erichsen, R., Kelsh, M. A., Oliner, K. S., Nielsen, K. B., Frøslev, T., Lænkholm, Anne-Vibeke, Vyberg, M., Acquavella, J. & Sørensen, H. T., Jul 2016, In: Annals of Epidemiology. 26, 7, p. 500-3 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Validation of prediction of local recurrence (LR) by Prosigna® (PAM50) in a Danish breast cancer cooperative group (DBCG) cohort of hormone receptor positive (HR+), postmenopausal early breast cancer (EBC) patients allocated to 5yr of endocrine therapy (ET)

    Eriksen, J. O., Jensen, M., Lænkholm, Anne-Vibeke, Kibøll, T., Rasmussen, B. B., Knoop, A. S., Ferree, S., Haffner, T., Buckingham, W., Schaper, C. & Ejlertsen, B., 2016, In: Cancer Research. 76, 4 Supplement, 1 p., P2-08-10.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  11. Published

    Evaluation of Nine Somatic Variant Callers for Detection of Somatic Mutations in Exome and Targeted Deep Sequencing Data

    Krøigård, A. B., Thomassen, M., Lænkholm, Anne-Vibeke, Kruse, T. A. & Larsen, M. J., 2016, In: PloS one. 11, 3, 15 p., e0151664.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Analytical validation of a standardized scoring protocol for Ki67: phase 3 of an international multicenter collaboration

    Leung, S. C. Y., Nielsen, T. O., Zabaglo, L., Arun, I., Badve, S. S., Bane, A. L., Bartlett, J. M. S., Borgquist, S., Chang, M. C., Dodson, A., Enos, R. A., Fineberg, S., Focke, C. M., Gao, D., Gown, A. M., Grabau, D., Gutierrez, C., Hugh, J. C., Kos, Z., Lænkholm, A-V. & 14 others, Lin, M., Mastropasqua, M. G., Moriya, T., Nofech-Mozes, S., Osborne, C. K., Penault-Llorca, F. M., Piper, T., Sakatani, T., Salgado, R., Starczynski, J., Viale, G., Hayes, D. F., McShane, L. M. & Dowsett, M., 2016, In: npj Breast Cancer. 2, p. 16014

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. 2015
  14. Gene expression profiling identifies FYN as an important molecule in tamoxifen resistance and a predictor of early recurrence in patients treated with endocrine therapy

    Elias, D., Vever, H., Lænkholm, Anne-Vibeke, Gjerstorff, M. F., Yde, C. W., Lykkesfeldt, A. E. & Ditzel, H. J., 9 Apr 2015, In: Oncogene. 34, 15, p. 1919-27 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Clonal expansion and linear genome evolution through breast cancer progression from pre-invasive stages to asynchronous metastasis

    Krøigård, A. B., Larsen, M. J., Lænkholm, Anne-Vibeke, Knoop, A. S., Jensen, J. D., Bak, M., Mollenhauer, J., Kruse, T. A. & Thomassen, M., 2015, In: OncoTarget. 6, 8, p. 5634-49 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Aurora kinase B is important for antiestrogen resistant cell growth and a potential biomarker for tamoxifen resistant breast cancer

    Larsen, S. L., Yde, C. W., Lænkholm, Anne-Vibeke, Rasmussen, B. B., Duun-Henriksen, A. K., Bak, M., Lykkesfeldt, A. E. & Kirkegaard, T., 8 Apr 2015, In: B M C Cancer. 15, 15 p., 239.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    SRC drives growth of antiestrogen resistant breast cancer cell lines and is a marker for reduced benefit of tamoxifen treatment

    Larsen, S. L., Lænkholm, Anne-Vibeke, Duun-Henriksen, A. K., Bak, M., Lykkesfeldt, A. E. & Kirkegaard, T., 2015, In: PloS one. 10, 2, e0118346.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    NADH-Cytochrome b5 Reductase 3 Promotes Colonization and Metastasis Formation and Is a Prognostic Marker of Disease-Free and Overall Survival in Estrogen Receptor-Negative Breast Cancer

    Lund, R. R., Leth-Larsen, R., Caterino, T. D., Terp, M. G., Nissen, J., Lænkholm, Anne-Vibeke, Jensen, O. N. & Ditzel, H. J., Nov 2015, In: Molecular and Cellular Proteomics. 14, 11, p. 2988-99 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    An international study to increase concordance in Ki67 scoring

    Polley, M-Y. C., Leung, S. C. Y., Gao, D., Mastropasqua, M. G., Zabaglo, L. A., Bartlett, J. M. S., McShane, L. M., Enos, R. A., Badve, S. S., Bane, A. L., Borgquist, S., Fineberg, S., Lin, M-G., Gown, A. M., Grabau, D., Gutierrez, C., Hugh, J. C., Moriya, T., Ohi, Y., Osborne, C. K. & 11 others, Penault-Llorca, F. M., Piper, T., Porter, P. L., Sakatani, T., Salgado, R., Starczynski, J., Lænkholm, Anne-Vibeke, Viale, G., Dowsett, M., Hayes, D. F. & Nielsen, T. O., 2015, In: Modern Pathology. 28, 6, p. 778-86 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Gene expression alterations associated with outcome in aromatase inhibitor-treated ER+ early-stage breast cancer patients

    Thomsen, K. G., Lyng, M. B., Elias, D., Vever, H., Knoop, A. S., Lykkesfeldt, A. E., Lænkholm, Anne-Vibeke & Ditzel, H. J., Dec 2015, In: Breast Cancer Research and Treatment. 154, 3, p. 483-94 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    A kinase inhibitor screen identifies Mcl-1 and Aurora kinase A as novel treatment targets in antiestrogen-resistant breast cancer cells

    Thrane, Susan, Pedersen, A. M., Thomsen, M. B. H., Kirkegaard, T., Rasmussen, B. B., Duun-Henriksen, A. K., Lænkholm, Anne-Vibeke, Bak, M., Lykkesfeldt, A. E. & Yde, C. W., 6 Aug 2015, In: Oncogene. 34, 32, p. 4199-210 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. 2014
  23. Published

    Estrogen receptor, Progesterone receptor, HER2 status and Ki67 index and responsiveness to adjuvant tamoxifen in postmenopausal high-risk breast cancer patients enrolled in the DBCG 77C trial

    Knoop, A. S., Lænkholm, Anne-Vibeke, Jensen, M., Nielsen, K. V., Andersen, J., Nielsen, D., Ejlertsen, B. & Danish Breast Cancer Cooperative Group, D. B. C. C. G., 2014, In: European journal of cancer (Oxford, England : 1990). 50, 8, p. 1412-1421 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    RNA profiling reveals familial aggregation of molecular subtypes in non-BRCA1/2 breast cancer families

    Larsen, M. J., Thomassen, M., Tan, Q., Lænkholm, Anne-Vibeke, Bak, M., Sørensen, K. P., Andersen, M. K., Kruse, T. A. & Gerdes, Anne-Marie Axø, 2014, In: B M C Medical Genomics. 7, p. 9

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. 2013
  26. Published

    Classifications within molecular subtypes enables identification of BRCA1/BRCA2 mutation carriers by RNA tumor profiling

    Larsen, M. J., Kruse, T. A., Tan, Q., Lænkholm, Anne-Vibeke, Bak, M., Lykkesfeldt, A. E., Sørensen, K. P., Hansen, Thomas van Overeem, Ejlertsen, Bent Laursen, Gerdes, Anne-Marie Axø & Thomassen, M., 2013, In: P L o S One. 8, 5, 12 p., e64268.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Gene expression signatures that predict outcome of tamoxifen-treated estrogen receptor-positive, high-risk, primary breast cancer patients: a DBCG study

    Lyng, M. B., Lænkholm, Anne-Vibeke, Tan, Q., Vach, W., Gravgaard, K. H., Knoop, A. & Ditzel, H., 2013, In: PLOS ONE. 8, 1, p. e54078

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. 2012
  29. Published

    PIK3CA mutations, PTEN, and pHER2 expression and impact on outcome in HER2-positive early-stage breast cancer patients treated with adjuvant chemotherapy and trastuzumab

    Jensen, J. D., Knoop, A., Lænkholm, Anne-Vibeke, Grauslund, M., Jensen, M. B., Santoni Rugiu, Eric, Andersson, M. & Ewertz, M., Aug 2012, In: Annals of oncology : official journal of the European Society for Medical Oncology. 23, 8, p. 2034-2042 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    ER, HER2, and TOP2A expression in primary tumor, synchronous axillary nodes, and asynchronous metastases in breast cancer

    Jensen, J. D., Knoop, A., Ewertz, M. & Lænkholm, Anne-Vibeke, Apr 2012, In: Breast Cancer Research and Treatment. 132, 2, p. 511-21 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    ESR1 gene status correlates with estrogen receptor protein levels measured by ligand binding assay and immunohistochemistry

    Lænkholm, Anne-Vibeke, Knoop, A., Ejlertsen, Bent Laursen, Rudbeck, T., Jensen, M., Müller, S., Lykkesfeldt, A. E., Rasmussen, B. B. & Nielsen, K. V., Aug 2012, In: Molecular Oncology. 6, 4, p. 428-36 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Activated HER-receptors in predicting outcome of ER-positive breast cancer patients treated with adjuvant endocrine therapy

    Larsen, M. S., Bjerre, K., Lykkesfeldt, A. E., Giobbie-Hurder, A., Lænkholm, Anne-Vibeke, Henriksen, K. L., Ejlertsen, Bent Laursen & Rasmussen, B. B., Oct 2012, In: Breast (Edinburgh, Scotland). 21, 5, p. 662-8 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 102813499