Anne Tybjærg-Hansen
Clinical Professor
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Novel mutations in leukotriene C4 synthase and risk of cardiovascular disease based on genotypes from 50,000 individuals
Freiberg, J. J., Tybjærg-Hansen, Anne & Nordestgaard, Børge, 1 Aug 2010, In: Journal of Thrombosis and Haemostasis. 8, 8, p. 1694-701 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Obesity increases heart failure incidence and mortality: observational and Mendelian randomization studies totalling over 1 million individuals
Benn, Marianne, Marott, S. C. W., Tybjærg-Hansen, Anne & Nordestgaard, Børge, 2022, In: Cardiovascular Research. 118, 18, p. 3576-3585 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Observational and genetic studies of C-reactive protein levels and risk of Alzheimer's disease
Frikke-Schmidt, Ruth, Hegazy, S. H., Rasmussen, I. J., Nordestgaard, Børge, Tybjærg-Hansen, Anne & Thomassen, J. Q., 2022, In: Alzheimer's and Dementia. 18, 12, p. 2734-2735Research output: Contribution to journal › Comment/debate › Research › peer-review
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Overview of the current status of familial hypercholesterolaemia care in over 60 countries - The EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)
Vallejo-Vaz, A. J., Marco, M. D., Stevens, C. A. T., Akram, A., Freiberger, T., Hovingh, G. K., Kastelein, J. J. P., Mata, P., Raal, F. J., Santos, R. D., Soran, H., Watts, G. F., Abifadel, M., Aguilar Salinas, C. A., Al-Khnifsawi, M., Alkindi, F. A., Alnouri, F., Alonso, R., Al-Rasadi, K., Al-Sarraf, A. & 248 others, , 2018, In: Atherosclerosis. 277, p. 234-255 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
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PCSK9 R46L Loss-of-Function Mutation Reduces Lipoprotein(a), LDL Cholesterol, and Risk of Aortic Valve Stenosis
Langsted, A., Nordestgaard, Børge, Benn, Marianne, Tybjærg-Hansen, Anne & Kamstrup, P. R., Sep 2016, In: The Journal of clinical endocrinology and metabolism. 101, 9, p. 3281-3287 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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PCSK9 R46L, low-density lipoprotein cholesterol levels, and risk of ischemic heart disease: 3 independent studies and meta-analyses
Benn, Marianne, Nordestgaard, Børge, Grande, P., Schnohr, P., Tybjærg-Hansen, Anne & Benn, M., 22 Jun 2010, In: Journal of the American College of Cardiology. 55, 25, p. 2833-42 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Penetrance of NOD2/CARD15 genetic variants in the general population
Yazdanyar, S., Kamstrup, P. R., Tybjærg-Hansen, Anne & Nordestgaard, Børge, 20 Apr 2010, In: C M A J. 182, 7, p. 661-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pentanucleotide repeat polymorphism, lipoprotein(a) levels, and risk of ischemic heart disease
Kamstrup, P. R., Tybjærg-Hansen, Anne, Steffensen, R. & Nordestgaard, B. G., 2008, In: Journal of Clinical Endocrinology and Metabolism. 93, 10, p. 3769-3776 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pharmacogenetics-guided CETP inhibition: an open question?
Tybjærg-Hansen, Anne, Nordestgaard, L. T. & Christoffersen, M., 2022, In: European Heart Journal. 43, 39, p. 3957-3959 3 p.Research output: Contribution to journal › Editorial › Research › peer-review
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Phenotype of heterozygotes for low-density lipoprotein receptor mutations identified in different background populations
Tybjærg-Hansen, Anne, Jensen, H. K., Benn, M., Steffensen, R., Jensen, G. & Nordestgaard, Børge, 2005, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 25, 1, p. 211-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Physical activity in leisure time and at work and risk of dementia: A prospective cohort study of 117,616 individuals
Juul Rasmussen, I., Rasmussen, Katrine Laura, Thomassen, J. Q., Nordestgaard, Børge, Schnohr, P., Tybjærg-Hansen, Anne & Frikke-Schmidt, Ruth, 2022, In: Atherosclerosis. 360, p. 53-60 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Plasma Concentrations of Calcium and Risk of Alzheimer Disease—Observational and Genetic Studies
Thomassen, J. Q., Nordestgaard, Børge, Tybjærg-Hansen, Anne & Frikke-Schmidt, Ruth, 2023, In: Clinical Chemistry. 69, 5, p. 525-536 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Plasma Concentrations of Magnesium and Risk of Dementia: A General Population Study of 102 648 Individuals
Thomassen, J. Q., Tolstrup, J. S., Nordestgaard, Børge, Tybjærg-Hansen, Anne & Frikke-Schmidt, Ruth, 2021, In: Clinical Chemistry. 67, 6, p. 899-911 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
Voight, B. F., Peloso, G. M., Orho-Melander, M., Frikke-Schmidt, R., Barbalic, M., Jensen, M. K., Hindy, G., Hólm, H., Ding, E. L., Johnson, T., Schunkert, H., Samani, N. J., Clarke, R., Hopewell, J. C., Thompson, J. F., Li, M., Thorleifsson, G., Newton-Cheh, C., Musunuru, K., Pirruccello, J. P. & 106 others, , 2012, In: Lancet. 380, 9841, p. 572-80 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Plasma TSH and cardiovascular disease in the general population: A Mendelian randomization study of 105,224 individuals
Dalila, N., Frikke-Schmidt, Ruth, Nordestgaard, Børge & Tybjærg-Hansen, Anne, 2023, In: Atherosclerosis. 376, p. 26-33 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Plasma YKL-40 and total and disease-specific mortality in the general population
Johansen, Julia Sidenius, Bojesen, Stig Egil, Tybjærg-Hansen, Anne, Mylin, A. K., Price, P. A. & Nordestgaard, Børge, 1 Oct 2010, In: Clinical Chemistry. 56, 10, p. 1580-91 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Plasma apolipoprotein E levels and risk of dementia: A Mendelian randomization study of 106,562 individuals
Rasmussen, K. L., Tybjærg-Hansen, Anne, Nordestgaard, Børge & Frikke-Schmidt, Ruth, Jan 2018, In: Alzheimer's & Dementia. 14, 1, p. 71-80Research output: Contribution to journal › Journal article › Research › peer-review
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Plasma high-density lipoprotein cholesterol and risk of dementia: observational and genetic studies
Kjeldsen, E. W., Thomassen, J. Q., Juul Rasmussen, I., Nordestgaard, Børge, Tybjærg-Hansen, Anne & Frikke-Schmidt, Ruth, 2022, In: Cardiovascular Research. 118, 5, p. 1330-1343 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Plasma levels of 27-hydroxycholesterol in humans and mice with monogenic disturbances of high density lipoprotein metabolism
Karuna, R., Holleboom, A. G., Motazacker, M. M., Kuivenhoven, J. A., Frikke-Schmidt, Ruth, Tybjærg-Hansen, Anne, Georgopoulos, S., van Eck, M., van Berkel, T. J. C., von Eckardstein, A. & Rentsch, K. M., 1 Feb 2011, In: Atherosclerosis. 214, 2, p. 448-55 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Plasma levels of apolipoprotein E and risk of dementia in the general population
Rasmussen, K. L., Tybjærg-Hansen, Anne, Nordestgaard, Børge & Frikke-Schmidt, Ruth, Feb 2015, In: Annals of Neurology. 77, 2, p. 301-11 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Plasma levels of apolipoprotein E and risk of ischemic heart disease in the general population
Rasmussen, K. L., Tybjærg-Hansen, Anne, Nordestgaard, Børge & Frikke-Schmidt, Ruth, Mar 2016, In: Atherosclerosis. 246, p. 63-70 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Plasma levels of apolipoprotein E, APOE genotype, and all-cause and cause-specific mortality in 105949 individuals from a white general population cohort
Rasmussen, K. L., Tybjærg-Hansen, Anne, Nordestgaard, Børge & Frikke-Schmidt, Ruth, 1 Sep 2019, In: European Heart Journal. 40, 33, p. 2813-2824 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Polygenic Risk Scores
Christoffersen, M. & Tybjærg-Hansen, Anne, 2022, Cardiovascular Risk Assessment in Primary Prevention. Humana Press, p. 429-446 (Contemporary Cardiology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Polygenic risk scores: how much do they add?
Christoffersen, M. & Tybjærg-Hansen, Anne, 2021, In: Current Opinion in Lipidology. 32, 3, p. 157-162 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Polymorphism in APOB associated with increased low-density lipoprotein levels in both genders in the general population
Benn, M., Nordestgaard, Børge, Jensen, J. S., Grande, P., Sillesen, H. & Tybjærg-Hansen, Anne, 2005, In: Journal of Clinical Endocrinology and Metabolism. 90, 10, p. 5797-803 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Polymorphisms in apolipoprotein B and risk of ischemic stroke
Benn, M., Nordestgaard, Børge, Jensen, J. S. & Tybjærg-Hansen, Anne, 2007, In: Journal of Clinical Endocrinology and Metabolism. 92, 9, p. 3611-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Population-Based Resequencing of APOA1 in 10,330 Individuals: Spectrum of Genetic Variation, Phenotype, and Comparison with Extreme Phenotype Approach
Haase, C. L., Frikke-Schmidt, R., Nordestgaard, Børge & Tybjærg-Hansen, Anne, 2012, In: P L o S Genetics. 8, 11, p. e1003063Research output: Contribution to journal › Journal article › Research › peer-review
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Postprandial Hypertriglyceridaemia Revisited in the Era of Non-Fasting Lipid Profile Testing: A 2019 Expert Panel Statement, Main Text
Kolovou, G. D., Watts, G. F., Mikhailidis, D. P., Pérez-Martínez, P., Mora, S., Bilianou, H., Panotopoulos, G., Katsiki, N., Ooi, T. C., Lopez-Miranda, J., Tybjærg-Hansen, Anne, Tentolouris, N. & Nordestgaard, Børge, 2019, In: Current Vascular Pharmacology. 17, 5, p. 498-514Research output: Contribution to journal › Journal article › Research › peer-review
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Postprandial Hypertriglyceridaemia Revisited in the Era of Non-Fasting Lipid Profile Testing: A 2019 Expert Panel Statement, Narrative Review
Kolovou, G. D., Watts, G. F., Mikhailidis, D. P., Pérez-Martínez, P., Mora, S., Bilianou, H., Panotopoulos, G., Katsiki, N., Ooi, T. C., Lopez-Miranda, J., Tybjærg-Hansen, Anne, Tentolouris, N. & Nordestgaard, Børge, 2019, In: Current Vascular Pharmacology. 17, 5, p. 515-537Research output: Contribution to journal › Review › Research › peer-review
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Postprandial Hypertriglyceridaemia Revisited in the Era of Non-fasting Lipid Profiles: Executive Summary of a 2019 Expert Panel Statement
Kolovou, G. D., Watts, G. F., Mikhailidis, D. P., Pérez-Martínez, P., Mora, S., Bilianou, H., Panotopoulos, G., Katsiki, N., Ooi, T. C., Lopez-Miranda, J., Tybjærg-Hansen, Anne, Tentolouris, N. & Nordestgaard, Børge, 2019, In: Current Vascular Pharmacology. 17, 5, p. 538-540Research output: Contribution to journal › Review › Research › peer-review
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Posttranscriptional Regulation of the Human LDL Receptor by the U2-Spliceosome
Zanoni, P., Panteloglou, G., Othman, A., Haas, J. T., Meier, R., Rimbert, A., Futema, M., Khalil, Y. A., Norrelykke, S. F., Rzepiela, A. J., Stoma, S., Stebler, M., Van Dijk, F., Wijers, M., Wolters, J. C., Dalila, N., Huijkman, N. C. A., Smit, M., Gallo, A., Carreau, V. & 26 others, , 2022, In: Circulation Research. 130, 1, p. 80-95 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Promotor polymorphisms in leukotriene C4 synthase and risk of ischemic cerebrovascular disease.
Freiberg, J. J., Tybjærg-Hansen, Anne, Sillesen, Henrik, Jensen, G. B., Nordestgaard, Børge, Freiberg, J. J., Tybjærg-Hansen, Anne, Sillesen, H., Jensen, G. B. & Nordestgaard, B. G., 2008, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 28, 5, p. 990-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
Turcot, V., Lu, Y., Highland, H. M., Bang, L. E., Benn, M., Kamstrup, P. R., Bork-Jensen, J., Frikke-Schmidt, R., Gjesing, A. P., Grarup, N., Hansen, T., Have, C. T., Jørgensen, T., Nielsen, S. F., Linneberg, A. R., Pedersen, O., Pers, T. H., Vestergaard, H., Nordestgaard, B., Tybjærg-Hansen, A. & 15 others, , 1 Jan 2018, In: Nature Genetics. 50, p. 26-41 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Prothrombin and risk of venous thromboembolism, ischemic heart disease and ischemic cerebrovascular disease in the general population
Weischer, M., Juul, K., Zacho, J., Jensen, G. B., Steffensen, R., Schroeder, T. V., Tybjærg-Hansen, Anne, Nordestgaard, B. G., Weischer, M., Juul, K., Zacho, J., Jensen, G. B., Steffensen, R., Schroeder, T. V., Tybjærg-Hansen, Anne & Nordestgaard, Børge, 1 Feb 2010, In: Atherosclerosis. 208, 2, p. 480-3 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Rare and low-frequency coding variants alter human adult height
Marouli, E., Graff, M., Medina-Gomez, C., Lo, K. S., Wood, A. R., Kjaer, T. R., Fine, R. S., Lu, Y., Schurmann, C., Highland, H. M., Rüeger, S., Thorleifsson, G., Justice, A. E., Lamparter, D., Stirrups, K. E., Turcot, V., Young, K. L., Winkler, T. W., Esko, T., Karaderi, T. & 31 others, , 9 Feb 2017, In: Nature. 542, 7640, p. 186-190 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease
CHD Exome+ Consortium, C. E. C., CARDIoGRAM Exome Consortium, C. E. C. & Global Lipids Genetics Consortium, G. L. G. C., 11 Mar 2016, In: Science (New York, N.Y.). 351, 6278, p. 1166-71 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes
Mahajan, A., Wessel, J., Willems, S. M., Zhao, W., Robertson, N. R., Chu, A. Y., Gan, W., Kitajima, H., Taliun, D., Rayner, N. W., Guo, X., Lu, Y., Li, M., Jensen, R. A., Hu, Y., Huo, S., Lohman, K. K., Zhang, W., Cook, J. P., Prins, B. P. & 32 others, , Apr 2018, In: Nature Genetics. 50, 4, p. 559-571 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Relationship between genetic variation at PPP1R3B and levels of liver glycogen and triglyceride
Stender, S., Smagris, E., Lauridsen, B. K., Kofoed, Klaus Fuglsang, Nordestgaard, Børge, Tybjærg-Hansen, Anne, Pennacchio, L. A., Dickel, D. E., Cohen, J. C. & Hobbs, H. H., 2018, In: Hepatology. 67, 6, p. 2182-2195 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Remnant Cholesterol, Low-Density Lipoprotein Cholesterol, and Blood Pressure as Mediators From Obesity to Ischemic Heart Disease
Varbo, A., Benn, Marianne, Smith, G. D., Timpson, N. J., Tybjærg-Hansen, Anne & Nordestgaard, Børge, Feb 2015, In: Circulation Research. 116, 4, p. 665-673 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Remnant cholesterol as a causal risk factor for ischemic heart disease
Varbo, A., Benn, M., Tybjærg-Hansen, Anne, Jørgensen, A. B., Frikke-Schmidt, R. & Nordestgaard, Børge, 2013, In: Journal of the American College of Cardiology. 61, 4, p. 427-36 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Reply to “Mendelian randomization highlights causal association between genetically increased C-reactive protein levels and reduced Alzheimer's disease risk”
Luo, J., Thomassen, J. Q., Hegazy, S. H., Rasmussen, I. J., Nordestgaard, Børge, Tybjærg-Hansen, Anne & Frikke-Schmidt, Ruth, 2022, In: Alzheimer's & Dementia. 18, 10, p. 2007-2009 3 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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Report of the 33rd annual conference of the European Lipoprotein Club, Tutzing, 6-9 September 2010
Bernini, F., Fisher, R., Freeman, D., Groen, A., Kalopissis, A., Malle, E., Mulder, M., Niemeier, A., Parini, P., Tybjærg-Hansen, Anne & von Eckardstein, A., 2011, In: Atherosclerosis. 215, 1, p. 249-55 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Repositioning of the global epicentre of non-optimal cholesterol
NCD Risk Factor Collaboration (NCD-RisC), N. R. F. C. (., Taddei, C., Zhou, B., Bixby, H., Nordestgaard, Børge, Benn, Marianne, Linneberg, Allan René, Tybjærg-Hansen, Anne, Cisneros, J. Z., Gregg, E. W., Ezzati, M. & Sørensen, Thorkild I.A., 2020, In: Nature. 582, 7810, p. 73-77Research output: Contribution to journal › Journal article › Research › peer-review
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Residual vascular risk in diabetes: Will the SPPARM alpha concept hold the key?
Fruchart, J. C., Santos, R. D., Yamashita, S., Libby, P., International Atherosclerosis Society/R3i Foundation Consensus Panel, I. A. S. F. C. P., Fruchart, J., Santos, R. D., Yamashita, S., Nordestgaard, Børge, Tybjærg-Hansen, Anne, Watts, G. F., Yokote, K. & Zambon, A., 2019, In: Diabetes and Metabolic Syndrome: Clinical Research and Reviews. 13, 4, p. 2723-2725Research output: Contribution to journal › Review › Research › peer-review
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Response to: liver fat content, non-alcoholic fatty liver disease, and ischaemic heart disease
Stender, S. & Tybjærg-Hansen, Anne, 2018, In: European Heart Journal. 39, 36, p. 3399Research output: Contribution to journal › Comment/debate › Research › peer-review
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Response to the Letter: Response to "Use of biomarkers to identify new drug targets and to predict risk of cardiometabolic outcomes" by Abasi A., et al
Holmegard, H. N., Nordestgaard, Børge, Jensen, G. B., Tybjærg-Hansen, Anne & Benn, Marianne, Feb 2016, In: The Journal of clinical endocrinology and metabolism. 101, 2, p. L22-L23Research output: Contribution to journal › Letter › Research › peer-review
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Risk of cancer by ATM missense mutations in the general population
Dombernowsky, S. L., Weischer, M., Allin, K. H., Bojesen, Stig Egil, Tybjærg-Hansen, Anne & Nordestgaard, B. G., 2008, In: Journal of Clinical Oncology. 26, 18, p. 3057-62 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Risk of cancer by transferrin saturation levels and haemochromatosis genotype: population-based study and meta-analysis
Ellervik, Christina, Tybjærg-Hansen, Anne, Nordestgaard, Børge, Ellervik, Christina, Tybjærg-Hansen, Anne & Nordestgaard, Børge, 2012, In: Journal of Internal Medicine. 271, 1, p. 51-63 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Risk of ischemic heart and ischemic cerebrovascular disease is not increased in S, Z, and 11478A alpha1-antitrypsin carriers of the Copenhagen City Heart Study
Dahl, M., Tybjærg-Hansen, Anne & Nordestgaard, Børge, 1 Nov 2003, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 23, 11, p. e55; author reply e55Research output: Contribution to journal › Journal article › Research › peer-review
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S1P, dihydro-S1P and C24:1-ceramide levels in the HDL-containing fraction of serum inversely correlate with occurrence of ischemic heart disease
Argraves, K. M., Sethi, A. A., Gazzolo, P. J., Wilkerson, B. A., Remaley, A. T., Tybjærg-Hansen, Anne, Nordestgaard, Børge, Yeatts, S. D., Nicholas, K. S., Barth, J. L. & Argraves, W. S., 2011, In: Lipids in Health and Disease. 10, p. 70Research output: Contribution to journal › Journal article › Research › peer-review
ID: 924951
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ABCA7 and risk of dementia and vascular disease in the Danish population
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256
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The UK10K project identifies rare variants in health and disease
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Data on plasma levels of apolipoprotein E, correlations with lipids and lipoproteins stratified by APOE genotype, and risk of ischemic heart disease
Research output: Contribution to journal › Journal article › Research › peer-review
Published