Jens Bukh

Jens Bukh

Professor

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    ORCID: 0000-0002-7815-4806

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    1. Published

      Hepatitis C virus epitope exposure and neutralization by antibodies is affected by time and temperature

      Sabo, M. C., Luca, V. C., Ray, S. C., Bukh, Jens, Fremont, D. H. & Diamond, M. S., 20 Jan 2012, In: Virology. 422, 2, p. 174-84 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Hepatitis C virus escape studies of human antibody AR3a reveal a high barrier to resistance and novel insights on viral antibody evasion mechanisms

      Velázquez-Moctezuma, R., Galli, Andrea, Law, M., Bukh, Jens & Prentø, Jannick, 2019, In: Journal of Virology. 93, 4, 27 p., e0190918.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Hepatitis C virus expressing flag-tagged envelope protein 2 has unaltered infectivity and density, is specifically neutralized by flag antibodies and can be purified by affinity chromatography

      Prentø, Jannick & Bukh, Jens, 2011, In: Virology. 409, 2, p. 148-55

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Hepatitis C virus expressing reporter tagged NS5A protein: Patent #: 8,772,022

      Gottwein, Judith Margarete, Scheel, T. K. H., Bukh, Jens, Prentø, Jannick & Jensen, T. B., 8 Jul 2014, IPC No. C12N 15/00 (20060101); C12N 5/00 (20060101); C12N 7/00 (20060101); C12N 15/64 (20060101); A61K 39/29 (20060101); C12N 7/01 (20060101), Patent No. WO2010/037403, 8 Apr 2010, Priority date 5 Oct 2009, Priority No. PCT/DK2009/050263

      Research output: Patent

    5. Published

      Hepatitis C virus host cell interactions uncovered

      Gottwein, J. & Bukh, Jens, 2007, In: Proceedings of the National Academy of Science of the United States of America. 104, 33, p. 13215-6

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Hepatitis C: the virus and studies of its lifecycle in cell culture systems

      Bukh, Jens, Gottwein, J. M., Scheel, T. K. & Forns, X., 2008, 100 Key Questions on Hepatitis C. Forns, X. (ed.). 1 ed. Barcelona, Spain: Permanyer Publications, Vol. 1. p. 1-15 14 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    7. Published

      High density Huh7.5 cell hollow fiber bioreactor culture for high-yield production of hepatitis C virus and studies of antivirals

      Pihl, A. F., Offersgaard, A. F., Mathiesen, C. K., Prentø, Jannick, Fahnøe, Ulrik, Krarup, H., Bukh, Jens & Gottwein, Judith Margarete, 2018, In: Scientific Reports. 8, 1, 13 p., 17505.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      High recombination rate of hepatitis C virus revealed by a green fluorescent protein reconstitution cell system

      Galli, Andrea, Fahnøe, Ulrik & Bukh, Jens, 2022, In: Virus Evolution. 8, 1, veab106.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Highly Efficient JFH1-Based Cell-Culture System for Hepatitis C Virus Genotype 5a: Failure of Homologous Neutralizing-Antibody Treatment to Control Infection

      Jensen, T. B., Gottwein, Judith Margarete, Scheel, Troels Kasper Høyer, Høgh, A. M., Eugen-Olsen, J. & Bukh, Jens, 2008, In: Journal of Infectious Diseases. 198, 12, p. 1756-1765 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system

      Li, Y., Ramirez, S., Jensen, S. B., Purcell, R. H., Gottwein, Judith Margarete & Bukh, Jens, 27 Nov 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 48, p. 19757-62 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Highly efficient infectious cell culture of three hepatitis C virus genotype 2b strains and sensitivity to lead protease, nonstructural protein 5A, and polymerase inhibitors

      Ramirez, S., Li, Y., Jensen, S. B., Pedersen, J., Gottwein, Judith Margarete & Bukh, Jens, Feb 2014, In: Hepatology. 59, 2, p. 395-407 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      High‐Titer Hepatitis C Virus Production in a Scalable Single‐Use High Cell Density Bioreactor

      Offersgaard, Anna Falden, Duarte Hernandez, C. R., Finne Pihl, A., Prabhakar Venkatesan, N., Krarup, H., Lin, X., Reichl, U., Bukh, Jens, Genzel, Y. & Gottwein, Judith Margarete, 2022, In: Vaccines. 10, 2, 249.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Host genetic variation guides hepacivirus clearance, chronicity, and liver fibrosis in mice

      Brown, A. J., Won, J. J., Wolfisberg, R., Fahnøe, U., Catanzaro, N., West, A., Moreira, F. R., Nogueira Batista, M., Ferris, M. T., Linnertz, C. L., Leist, S. R., Nguyen, C., De La Cruz, G., Midkiff, B. R., Xia, Y., Evangelista, M. D., Montgomery, S. A., Billerbeck, E., Bukh, J., Scheel, T. K. H. & 2 others, Rice, C. M. & Sheahan, T. P., 2024, In: Hepatology. 79, 1, p. 183-197

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus

      Giang, E., Dorner, M., Prentø, Jannick, Dreux, M., Evans, M. J., Bukh, Jens, Rice, C. M., Ploss, A., Burton, D. R. & Law, M., 17 Apr 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 16, p. 6205-10 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Human monoclonal antibodies to a novel cluster of conformational epitopes on HCV E2 with resistance to neutralization escape in a genotype 2a isolate

      Keck, Z., Xia, J., Wang, Y., Wang, W., Krey, T., Prentø, Jannick, Carlsen, T., Li, A. Y., Patel, A. H., Lemon, S. M., Bukh, Jens, Rey, F. A. & Foung, S. K. H., 2012, In: P L o S Pathogens. 8, 4, 21 p., e1002653.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Hypervariable Region 1 Shielding of Hepatitis C Virus Is a Main Contributor to Genotypic Differences in Neutralization Sensitivity

      Prentø, Jannick, Velazquez-Moctezuma, R., Foung, S. K. H., Law, M. & Bukh, Jens, Dec 2016, In: Hepatology. 64, 6, p. 1881-1892 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Hypervariable Region 1 in Envelope Protein 2 of Hepatitis C Virus: A Linchpin in Neutralizing Antibody Evasion and Viral Entry

      Prentø, Jannick & Bukh, Jens, 2018, In: Frontiers in Immunology. 9, 11 p., 2146.

      Research output: Contribution to journal › Review › Research › peer-review

    18. Published

      Hypervariable region 1 and N-linked glycans of hepatitis C regulate virion neutralization by modulating envelope conformations

      Prentø, Jannick, Velázquez-Moctezuma, R., Augestad, E. H., Galli, Andrea, Wang, R., Law, M., Alter, H. & Bukh, Jens, 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 20, p. 10039-10047 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Hypervariable region 1 deletion and required adaptive envelope mutations confer decreased dependency on scavenger receptor class B type I and low-density lipoprotein receptor for hepatitis C virus

      Prentø, Jannick, Serre, S. B. N., Ramirez, S., Nicosia, A. & Bukh, Jens, Feb 2014, In: Journal of Virology. 88, 3, p. 1725-39 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Hypervariable region 1 differentially impacts viability of hepatitis C virus strains of genotypes 1 to 6 and impairs virus neutralization

      Prentø, Jannick, Jensen, T. B., Meuleman, P., Serre, S., Scheel, Troels Kasper Høyer, Leroux-Roels, G., Gottwein, J. & Bukh, Jens, 2011, In: Journal of Virology. 85, 5, p. 2224-34 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Identification of Piperazinylbenzenesulfonamides as New Inhibitors of Claudin-1 Trafficking and Hepatitis C Virus Entry

      Riva, L., Song, O., Prentø, Jannick, Helle, F., L'homme, L., Gattolliat, C., Vandeputte, A., Feneant, L., Belouzard, S., Baumert, T. F., Asselah, T., Bukh, Jens, Brodin, P., Cocquerel, L., Rouille, Y. & Dubuisson, J., 1 May 2018, In: Journal of Virology. 92, 10, 19 p., e01982-17.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Identification of alpha interferon-induced envelope mutations of hepatitis C virus in vitro associated with increased viral fitness and interferon resistance

      Serre, S. B. N., Krarup, H. B., Bukh, Jens & Gottwein, Judith Margarete, Dec 2013, In: Journal of Virology. 87, 23, p. 12776-93 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Identification of novel neutralizing determinants for protection against HCV

      Alzua, G. P., Pihl, A. F., Offersgaard, Anna Falden, Velázquez-Moctezuma, R., Duarte Hernandez, Carlos Rene, Augestad, Elias Honerød, Fahnøe, Ulrik, Mathiesen, C. K., Krarup, H., Law, M., Prentø, Jannick, Bukh, Jens & Gottwein, Judith Margarete, 2023, In: Hepatology. 73, 3, p. 982-996

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Identification of specific amino acid residues in the border disease virus glycoprotein E2 that modify virus growth in pig cells but not in sheep cells

      Fahnøe, Ulrik, Deng, Y., Davids, N. A., Lohse, L., Bukh, Jens, Belsham, Graham John & Rasmussen, T. B., 2020, In: The Journal of general virology. 101, 11, p. 1170-1181

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Identification of the viral and cellular microRNA interactomes during SARS-CoV-2 infection

      Fossat, Nicolas Julien, Lundsgaard, Emma Alberte, Costa, Rui, Rivera, Lizandro, Nielsen, L., Mikkelsen, L. S., Ramirez Almeida, Santseharay, Bukh, Jens & Scheel, Troels Kasper Høyer, 2023, In: Cell Reports. 42, 4, 112282.

      Research output: Contribution to journal › Journal article › Research › peer-review

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    ID: 12437