Niels Erik Skakkebæk

Niels Erik Skakkebæk

Affiliate Professor

Member of:

  • Paediatrics


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  1. Published

    Growth hormone treatment of non-elderly adults with GH-deficiency

    Christiansen, J., Jørgensen, J., Vahn, N., Juul, Anders, Müller, J. & Skakkebæk, Niels Erik, 1995, GHRH, GH and IGF-1: Basic and clinical Advances. p. 169-175 6 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  2. Published

    Growth hormone, insulin-like growth factor I and its binding proteins 1 and 3 in last trimester intrauterine growth retardation with increased pulsatility index in the umbilical artery

    Larsen, T., Main, Katharina Maria, Andersson, A. M., Juul, Anders, Greisen, Gorm & Skakkebæk, Niels Erik, 1996, In: Clinical Endocrinology. 45, 3, p. 315-9 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Habitual alcohol consumption associated with reduced semen quality and changes in reproductive hormones; a cross-sectional study among 1221 young Danish men

    Jensen, T. K., Gottschau, M., Madsen, J. O. B., Andersson, A., Lassen, T. H., Skakkebæk, Niels Erik, Swan, S. H., Priskorn, L., Juul, Anders & Jørgensen, N., 2014, In: B M J Open. 4, 9, p. 1-11 11 p., e005462.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Heterozygous deletion at the RLN1 locus in a family with testicular germ cell cancer identified by integrating copy number variation data with phenome and interactome information

    Edsgärd, D., Scheel, M., Hansen, N. T., Ralfkiaer, U., Jensen, T. S., Skakkebæk, Niels Erik, Brunak, S., Gupta, R., Rajpert-De Meyts, E. & Ottesen, A. M., 1 Aug 2011, In: International Journal of Andrology. 34, 4 Pt 2, p. e122-32

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    High maternal age at first and subsequent child births in Denmark in the mid-1800s-Letter to the editor

    Priskorn, L., Dahl, C. L., Pihl, A. S., Skakkebæk, Niels Erik & Juul, Anders, Oct 2019, In: European Journal of Obstetrics & Gynecology and Reproductive Biology. 241, p. 137-138 2 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  6. Published

    High normal testosterone levels in infants with non-mosaic Klinefelter's syndrome

    Aksglaede, L., Petersen, Jørgen Holm, Main, Katharina Maria, Skakkebæk, Niels Erik & Juul, Anders, 2007, In: European Journal of Endocrinology. 157, 3, p. 345-50 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Histological evidence of testicular dysgenesis in contralateral biopsies from 218 patients with testicular germ cell cancer

    Hoei-Hansen, C. E., Holm, M., Rajpert-De Meyts, E. & Skakkebæk, Niels Erik, 1 Jul 2003, In: Journal of Pathology. 200, 3, p. 370-4 5 p.

    Research output: Contribution to journal › Journal article › Research

  8. Published

    Histopathological Evaluation of Testicular Biopsy

    Rajpert-de Meyts, E., Grigor, K. M. & Skakkebæk, Niels Erik, 2017, Endocrinology of the Testis and Male Reproduction. SimoniIlpo, M. & Huhtaniemi, I. (eds.). p. 1-20 (Endocrinology of the Testis and Male Reproduction).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  9. Published

    Hormonal changes during GnRH analogue therapy in children with central precocious puberty

    Müller, J., Juul, Anders, Andersson, A. M., Sehested, A. & Skakkebæk, Niels Erik, 2000, In: Journal of Pediatric Endocrinology and Metabolism. 13 Suppl 1, p. 739-46 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age

    Main, Katharina Maria, Mortensen, G. K., Kaleva, M. M., Boisen, K. A., Damgaard, I. N., Chellakooty, M., Schmidt, I. M., Suomi, A., Virtanen, H. E., Petersen, J. H., Andersson, A., Toppari, J. & Skakkebæk, Niels Erik, 2006, In: Environmental Health Perspectives. 114, 2, p. 270-276 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Human semen quality in the new millennium: a prospective cross-sectional population-based study of 4867 men

    Jørgensen, N., Joensen, Ulla Nordström, Jensen, T., Jensen, M., Almstrup, Kristian, Olesen, I., Juul, A., Andersson, A., Carlsen, E., Petersen, Jørgen Holm, Toppari, J. & Skakkebæk, Niels Erik, 2012, In: B M J Open. 2, 4, e000990.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Human sperm cells can form paracetamol metabolite AM404 that directly interferes with sperm calcium signalling and function through a CatSper-dependent mechanism

    Rehfeld, Anders Aagaard, Frederiksen, H., Rasmussen, R. H., David, A., Chaker, J., Nielsen, B. S., Nielsen, J. E., Juul, Anders, Skakkebæk, Niels Erik & Kristensen, D. M., 2022, In: Human reproduction (Oxford, England). 37, 5, p. 922-935 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Human urinary excretion of non-persistent environmental chemicals: an overview of Danish data collected between 2006 and 2012

    Frederiksen, H., Jensen, T. K., Jørgensen, N., Kyhl, H. B., Husby, S., Skakkebæk, Niels Erik, Main, Katharina Maria, Juul, Anders & Andersson, A., 2014, In: Reproduction. 147, 4, p. 555-565 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Hypothesis: Metformin is a potential reproductive toxicant

    Tavlo, M., Skakkebæk, Niels Erik, Mathiesen, Elisabeth, Kristensen, D. M., Kjær, Kurt H., Andersson, A. & Lindahl-Jacobsen, R., 2022, In: Frontiers in Endocrinology. 13, 8 p., 1000872.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Hypothesis: exposure to endocrine-disrupting chemicals may interfere with timing of puberty

    Mouritsen, Annette Korsholm, Aksglaede, L., Sørensen, K., Mogensen, S. S., Leffers, H., Main, Katharina Maria, Frederiksen, H., Andersson, A., Skakkebæk, Niels Erik & Juul, Anders, 1 Apr 2010, In: International Journal of Andrology. 33, 2, p. 346-59 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Identification and expression profiling of 10 novel spermatid expressed CYPT genes

    Hansen, M. A., Nielsen, J. E., Tanaka, M., Almstrup, Kristian, Skakkebæk, Niels Erik & Leffers, H., May 2006, In: Molecular Reproduction and Development. 73, 5, p. 568-579 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Identification of genes differentially expressed in testes containing carcinoma in situ

    Høi-Hansen, Christina Engel, Nielsen, J. E., Almstrup, Kristian, Hansen, M. A., Skakkebæk, Niels Erik, Rajpert-DeMeyts, E. & Leffers, H., Jun 2004, In: Molecular Human Reproduction. 10, 6, p. 423-431 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Identity of M2A (D2-40) antigen and gp36 (Aggrus, T1A-2, podoplanin) in human developing testis, testicular carcinoma in situ and germ-cell tumours

    Sonne, Si Brask, Herlihy, A. S., Hoei-Hansen, C. E., Nielsen, J. E., Almstrup, Kristian, Skakkebæk, Niels Erik, Marks, A., Leffers, H. & Rajpert-De Meyts, E., 2006, In: Virchows Archiv. 449, 2, p. 200-6 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Immunohistochemical expression of embryonal marker TRA-1-60 in carcinoma in situ and germ cell tumors of the testis

    Giwercman, A., Andrews, P. W., Jørgensen, N., Müller, J., Graem, N. & Skakkebæk, Niels Erik, 15 Aug 1993, In: Cancer. 72, 4, p. 1308-14 7 p.

    Research output: Contribution to journal › Journal article › Research

  20. Published

    Impact of growth hormone administration on other hormonal axes.

    Jørgensen, J., Ovesen, P., Juul, Anders, Hansen, T., Skakkebæk, Niels Erik & Christiansen, J., 1999, In: Hormone Research. 51, p. 121-126 5 p.

    Research output: Contribution to journal › Review › Research

  21. Published

    Impact of psychological stress measured in three different scales on testis function: A cross-sectional study of 1362 young men

    Nordkap, L., Priskorn, L., Bräuner, E. V., Hansen, Åse Marie, Kirstine Bang, A., Holmboe, S. A., Winge, S. B., Egeberg Palme, D. L., Mørup, N., Skakkebæk, Niels Erik, Kold Jensen, T. & Jørgensen, N., 2020, In: Andrology. 8, 6, p. 1674-1686 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Impaired testicular function in patients with carcinoma-in-situ of the testis

    Petersen, P. M., Giwercman, A., Hansen, S. W., Berthelsen, Jens, Daugaard, G., Rørth, M. & Skakkebæk, Niels Erik, 1999, In: Journal of Clinical Oncology. 17, 1, p. 173-9 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Impaired thermoregulation in adults with growth hormone deficiency during heat exposure and exercise

    Juul, Anders, Behrenscheer, A., Tims, T., Nielsen, B., Halkjaer-Kristensen, J. & Skakkebæk, Niels Erik, 1993, In: Clinical Endocrinology. 38, 3, p. 237-244 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Improved gene expression signature of testicular carcinoma in situ

    Almstrup, Kristian, Leffers, H., Lothe, R. A., Skakkebæk, Niels Erik, Sonne, Si Brask, Nielsen, J. E., Rajpert-De Meyts, E. & Skotheim, R. I., 2007, In: International Journal of Andrology. 30, 4, p. 292-303

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Increase in first morning voided urinary luteinizing hormone levels precedes the physical onset of puberty

    Demir, A., Voutilainen, R., Juul, Anders, Dunkel, L., Alfthan, H., Skakkebæk, Niels Erik & Stenman, U. H., 1996, In: Journal of Clinical Endocrinology and Metabolism. 81, 8, p. 2963-7 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Increase in maternal placental growth hormone during pregnancy and disappearance during parturition in normal and growth hormone-deficient pregnancies

    Lønberg, U., Damm, Peter, Andersson, A., Main, Katharina Maria, Chellakooty, M., Lauenborg, J., Skakkebæk, Niels Erik & Juul, Anders, 1 Jan 2003, In: American Journal of Obstetrics and Gynecology. 188, 1, p. 247-51 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Increased expression of alpha- and beta-globin mRNAs at the pituitary following exposure to estrogen during the critical period of neonatal sex differentiation in the rat

    Leffers, H., Navarro, V. M., Nielsen, J. E., Mayen, A., Pinilla, L., Dalgaard, M., Malagon, M. M., Castaño, J. P., Skakkebæk, Niels Erik, Aguilar, E. & Tena-Sempere, M., 1 Apr 2006, In: Journal of Steroid Biochemistry and Molecular Biology. 99, 1, p. 33-43 11 p.

    Research output: Contribution to journal › Journal article › Research

  28. Published

    Increased risk of carcinoma in situ in patients with testicular germ cell cancer with ultrasonic microlithiasis in the contralateral testicle

    Holm, M., Hoei-Hansen, C. E., Rajpert-De Meyts, E. & Skakkebæk, Niels Erik, 1 Oct 2003, In: Journal of Urology. 170, 4 Pt 1, p. 1163-7 5 p.

    Research output: Contribution to journal › Journal article › Research

  29. Published

    Increasing international efforts to understand and conquer testicular germ cell cancer

    Rajpert-De Meyts, E., Daugaard, G., Almstrup, Kristian, Jørgensen, A., Rørth, M., Jørgensen, N., von der Maase, H. & Skakkebæk, Niels Erik, Jan 2015, In: Andrology. 3, 1, p. 1-3 3 p.

    Research output: Contribution to journal › Editorial › Research › peer-review

  30. Published

    Increasing trends in childlessness in recent birth cohorts - a registry-based study of the total Danish male population born from 1945 to 1980

    Priskorn, L., Holmboe, S., Jacobsen, R., Jensen, T. K., Lassen, T. H. & Skakkebæk, Niels Erik, 2012, In: International Journal of Andrology. 35, 3, p. 449-55 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Individual testosterone decline and future mortality risk in men

    Holmboe, S. A., Skakkebæk, Niels Erik, Juul, Anders, Scheike, Thomas, Jensen, T. K., Linneberg, Allan René, Thuesen, B. H. & Andersson, A., Jan 2018, In: European Journal of Endocrinology. 178, p. 121-128

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Influence of FGF23 and Klotho on male reproduction: Systemic vs direct effects

    Hansen, Lasse Bøllehuus, Kaludjerovic, J., Nielsen, J. E., Rehfeld, Anders Aagaard, Poulsen, N. N., Ide, N., Skakkebæk, Niels Erik, Frederiksen, H., Juul, Anders, Lanske, B. & Jensen, M. B., 2020, In: F A S E B Journal. 34, 9, p. 12436-12449

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Influence of marital status on testosterone levels-A ten year follow-up of 1113 men

    Holmboe, S. A., Priskorn, L., Jørgensen, N., Skakkebæk, Niels Erik, Linneberg, Allan René, Juul, Anders & Andersson, A., 2017, In: Psychoneuroendocrinology. 80, p. 155-161 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Inhibin A, inhibin B, follicle-stimulating hormone, luteinizing hormone, estradiol, and sex hormone-binding globulin levels in 473 healthy infant girls

    Chellakooty, M., Schmidt, I. M., Haavisto, A. M., Boisen, K. A., Damgaard, I. N., Mau, C., Petersen, Jørgen Holm, Juul, Anders, Skakkebæk, Niels Erik & Main, Katharina Maria, 2003, In: Journal of Clinical Endocrinology and Metabolism. 88, 8, p. 3515-20 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Insulin-like factor 3 levels in cord blood and serum from children: effects of age, postnatal hypothalamic-pituitary-gonadal axis activation, and cryptorchidism

    Bay, K., Virtanen, H. E., Hartung, S., Ivell, R., Main, Katharina Maria, Skakkebæk, Niels Erik, Andersson, A., Toppari, J. & Nordic Cryptorchidism Study Group, N. C. S. G., 1 Oct 2007, In: Journal of Clinical Endocrinology and Metabolism. 92, 10, p. 4020-7 8 p.

    Research output: Contribution to journal › Journal article › Research

  36. Published

    Insulin-like factor 3 levels in second-trimester amniotic fluid

    Bay, K., Cohen, A. S., Jørgensen, Finn Stener, Jørgensen, C., Lind, A. M., Skakkebæk, Niels Erik & Andersson, A., 1 Oct 2008, In: Journal of Clinical Endocrinology and Metabolism. 93, 10, p. 4048-51 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Insulin-like growth factor I (IGF-I) and IGF-binding protein 3 as diagnostic markers of growth hormone deficiency in infancy

    Jensen, R. B., Jeppesen, K. A., Vielwerth, S., Michaelsen, K. F., Main, Katharina Maria, Skakkebæk, Niels Erik & Juul, Anders, 2005, In: Hormone Research. 63, 1, p. 15-21 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Intranasal LH-RH treatment of cryptorchidism. A clinical trial and 5 years follow-up

    Thorup, Jørgen Mogens, Mauritzen, K. & Skakkebæk, Niels Erik, 1987, In: European Journal of Pediatrics. 146 Suppl 2, p. S40-1

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Intranasalt gonadotropinfrigørende hormon (LH-RH) som behandling ved retentio testis

    Bertelsen, A., Skakkebæk, Niels Erik, Mauritzen, K., Preuss, P., Pedersen, P. V. & Thorup, Jørgen Mogens, 15 Jun 1981, In: Ugeskrift for Laeger. 143, 25, p. 1595-7 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat

    Kristensen, D. M., Hass, U., Lesné, L., Lottrup, G., Jacobsen, P. R., Desdoits-Lethimonier, C., Boberg, J., Petersen, Jørgen Holm, Toppari, J., Jensen, T. K., Brunak, Søren, Skakkebæk, Niels Erik, Nellemann, C., Main, Katharina Maria, Jégou, B. & Leffers, H., 2011, In: Human Reproduction. 26, 1, p. 235-44 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Intrauterine growth retardation and consequences for endocrine and cardiovascular diseases in adult life: does insulin-like growth factor-I play a role?

    Jensen, R. B. B., Chellakooty, M., Vielwerth, S., Vaag, Allan, Larsen, T. K., Greisen, Gorm, Skakkebæk, Niels Erik, Scheike, T. H. & Juul, Anders, 2003, In: Hormone Research. 60 Suppl 3, p. 136-48 13 p.

    Research output: Contribution to journal › Journal article › Research

  42. Published

    In vitro bioassay investigations of the endocrine disrupting potential of steviol glycosides and their metabolite steviol, components of the natural sweetener Stevia

    Shannon, M., Rehfeld, Anders Aagaard, Frizzell, C., Livingstone, C., McGonagle, C., Skakkebæk, Niels Erik, Wielogórska, E. & Connolly, L., 15 May 2016, In: Molecular and Cellular Endocrinology. 427, p. 65-72

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Is Sedentary Lifestyle Associated With Testicular Function? A Cross-Sectional Study of 1,210 Men

    Priskorn, L., Jensen, T. K., Bang, A. K., Nordkap, L., Joensen, Ulla Nordström, Lassen, T. H., Olesen, I. A., Swan, S. H., Skakkebæk, Niels Erik & Jørgensen, N., 15 Aug 2016, In: American Journal of Epidemiology. 184, 4, p. 284-294 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Is human fecundity changing? A discussion of research and data gaps precluding us from having an answer

    Smarr, M. M., Sapra, K. J., Gemmill, A., Kahn, L. G., Wise, L. A., Lynch, C. D., Factor-Litvak, P., Mumford, S. L., Skakkebæk, Niels Erik, Slama, R., Lobdell, D. T., Stanford, J. B., Jensen, T. K., Boyle, E. H., Eisenberg, M. L., Turek, P. J., Sundaram, R., Thoma, M. E. & Buck Louis, G. M., 2017, In: Human Reproduction. 32, 3, p. 499-504

    Research output: Contribution to journal › Comment/debate › Research

  45. Published

    Is human fecundity declining?

    Skakkebæk, Niels Erik, Jørgensen, N., Main, Katharina Maria, Rajpert-De Meyts, E., Leffers, H., Andersson, A., Juul, Anders, Carlsen, E., Mortensen, G. K., Jensen, T. K. & Toppari, J., 1 Feb 2006, In: International Journal of Andrology. 29, 1, p. 2-11 10 p.

    Research output: Contribution to journal › Journal article › Research

  46. Published

    Is the FSHR 2039A>G variant associated with susceptibility to testicular germ cell cancer?

    Bang, A. K., Busch, A. S., Almstrup, Kristian, Gromoll, J., Kliesch, S., Rajpert-De Meyts, E., Skakkebæk, Niels Erik, Juul, Anders, Tüttelmann, F. & Jørgensen, N., 2018, In: Andrology. 6, 1, p. 176-183 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Is there a problem with male reproduction?

    Joensen, Ulla Nordström, Skakkebæk, Niels Erik & Jørgensen, N., 2009, In: Nature Clinical Practice Endocrinology & Metabolism. 5, 3, p. 144-5 1 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Klinefelter syndrome comorbidities linked to increased X chromosome gene dosage and altered protein interactome activity

    Belling, K., Russo, F., Jensen, A. B., Dalgaard, M. D., Westergaard, David, Rajpert-De Meyts, E., Skakkebæk, Niels Erik, Juul, Anders & Brunak, Søren, 1 Apr 2017, In: Human Molecular Genetics. 26, 7, p. 1219-1229 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Klinefelter syndrome: the forgotten syndrome: basic and clinical questions posed to an international group of scientists

    Juul, Anders, Aksglaede, L., Bay, K., Grigor, K. M. & Skakkebæk, Niels Erik, 1 Jun 2011, In: Acta Paediatrica. 100, 6, p. 791-2 2 p.

    Research output: Contribution to journal › Conference article › Research

  50. Published

    Lack of stimulation of 24-hour growth hormone release by hypocaloric diet in obesity

    Rasmussen, M. H., Juul, Anders, Kjems, L. L., Skakkebæk, Niels Erik & Hilsted, J., 1995, In: Journal of Clinical Endocrinology and Metabolism. 80, 3, p. 796-801 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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