Jens Bukh

Jens Bukh

Professor

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    ORCID: 0000-0002-7815-4806

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    1. Published

      First-in-human use of a modular capsid virus-like vaccine platform: An open-label, non-randomised, phase 1 clinical trial of the SARS-CoV-2 vaccine ABNCoV2

      Smit, M. J., Sander, A. F., Ariaans, M. B. P. A., Fougeroux, C., Heinzel, C., Fendel, R., Esen, M., Kremsner, P. G., Ter Heine, R., Wertheim, H. F., Idorn, M., Paludan, S. R., Underwood, A. P., Binderup, A., Ramirez, S., Bukh, J., Soegaard, M., Erdogan, S. M., Gustavsson, T., Clemmensen, S. & 14 others, Theander, Thor Grundtvig, Salanti, Ali, Hamborg, M., de Jongh, W. A., McCall, M. B. B., Nielsen, Morten Agertoug, Mordmüller, B. G., COUGH-1 trial study group, C. T. S. G., Dagil, Robert, Goksøyr, L., Hulen, T. M., Brygger, C. M. J., Khalifé, P. K. & Vidal-Calvo, E. E., 2023, In: The Lancet Microbe. 4, 3, p. e140-e148

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Full-length open reading frame amplification of hepatitis C virus

      Fahnøe, Ulrik & Bukh, Jens, 2019, Hepatitis C Virus Protocols. Humana Press, p. 85-91 7 p. (Methods in Molecular Biology, Vol. 1911).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    3. Published

      Full-length sequence analysis of hepatitis C virus genotype 3b strains and development of an in vivo infectious 3b cDNA clone

      Bajpai, P. S., Collignon, Laura Maria F, Sølund, C., Madsen, L. W., Christensen, P. B., Øvrehus, A., Weis, Nina, Holmbeck, Kenn, Fahnøe, Ulrik & Bukh, Jens, 2023, In: Journal of Virology. 97, 12, 23 p., 00925.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Functional analyses of GB virus B p13 protein: Development of a recombinant GB virus B hepatitis virus with a p7 protein

      Takikawa, S., Engle, R. E., Emerson, S. U., Purcell, R. H., St Claire, M. & Bukh, Jens, 2006, In: Proceedings of the National Academy of Science of the United States of America. 103, 9, p. 3345-50 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Functional analysis of microRNA-122 binding sequences of hepatitis C virus and identification of variants with high resistance against specific antagomir

      Li, Y., Pham, Long, Uzcategui, N. & Bukh, Jens, Jun 2016, In: Journal of General Virology. 97, p. 1381-1394

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Functional convergence of a germline-encoded neutralizing antibody response in rhesus macaques immunized with HCV envelope glycoproteins

      Chen, F., Tzarum, N., Lin, X., Giang, E., Velázquez-Moctezuma, R., Augestad, Elias Honerød, Nagy, K., He, L., Hernandez, M., Fouch, M. E., Grinyó, A., Chavez, D., Doranz, B. J., Prentø, Jannick, Stanfield, R. L., Lanford, R., Bukh, Jens, Wilson, I. A., Zhu, J. & Law, M., 2021, In: Immunity. 54, 4, p. 781-796.e4

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies

      Tzarum, N., Giang, E., Kong, L., He, L., Prentø, Jannick, Augestad, E., Hua, Y., Castillo, S., Lauer, G. M., Bukh, Jens, Zhu, J., Wilson, I. A. & Law, M., 2019, In: Science Advances. 5, 1, 12 p., eaav1882.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Genetic variation in toll-like receptors and retinoic acid-inducible gene I and outcome of hepatitis C virus infection: a candidate gene association study

      Clausen, L. N., Ladelund, S., Weis, Nina, Bukh, Jens & Benfield, Thomas, Aug 2014, In: Journal of Viral Hepatitis. 21, 8, p. 578-84 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Genome sequence of an unknown subtype of hepatitis C virus genotype 6: Another piece for the taxonomic puzzle

      Pedersen, M. S., Mollerup, S., Nielsen, L. G., Jenssen, H., Bukh, Jens & Schønning, Kristian, 2019, In: Microbiology resource announcements. 8, 42, e01030-19.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Global and local envelope protein dynamics of hepatitis C virus determine broad antibody sensitivity

      Augestad, E. H., Castelli, M., Clementi, N., Ströh, L. J., Krey, T., Burioni, R., Mancini, N., Bukh, Jens & Prentø, Jannick, 2020, In: Science Advances. 6, 35, 13 p., eabb5938.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Global evolutionary analysis of chronic hepatitis C patients revealed significant effect of baseline viral resistance, including novel non-target sites, for DAA-based treatment and retreatment outcome

      Fahnøe, Ulrik, Pedersen, M. S., Sølund, C., Ernst, A., Krarup, H. B., Røge, B. T., Christensen, P. B., Laursen, A. L., Gerstoft, Jan, Thielsen, P., Madsen, Lone Galmstrup, Pedersen, A. G., Schønning, Kristian, Weis, Nina & Bukh, Jens, 2021, In: Journal of Viral Hepatitis. 28, 2, p. 302-316

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      HCV Genotype 6a Escape from and Resistance to Velpatasvir, Pibrentasvir, and Sofosbuvir in Robust Infectious Cell Culture Models

      Pham, Long, Ramirez Almeida, Santseharay, Gottwein, Judith Margarete, Fahnøe, Ulrik, Li, Y., Pedersen, J. & Bukh, Jens, 2018, In: Gastroenterology. 154, 8, p. 2194-2208.e12

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      HCV genome-wide analysis for development of efficient culture systems and unravelling of antiviral resistance in genotype 4

      Pham, Long, Pedersen, M. S., Fahnøe, Ulrik, Fernandez-Antunez, C., Humes, D., Schønning, Kristian, Ramirez Almeida, Santseharay & Bukh, Jens, 2022, In: Gut. 71, p. 627-642 20323585.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      HCV genotype 1-6 NS3 residue 80 substitutions impact protease inhibitor activity and promote viral escape

      Pham, Long, Jensen, S. B., Fahnøe, Ulrik, Pedersen, M. S., Tang, Q., Ghanem, L., Ramirez Almeida, Santseharay, Humes, D., Serre, S. B. N., Schønning, Kristian, Bukh, Jens & Gottwein, Judith Margarete, 2019, In: Journal of Hepatology. 70, 3, p. 388-397

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      HCV p7 as a novel vaccine-target inducing multifunctional CD4+ and CD8+ T-cells targeting liver cells expressing the viral antigen

      Filskov, J., Andersen, P., Agger, E. M. & Bukh, Jens, 2019, In: Scientific Reports. 9, 1, 13 p., 14085.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      HVR1-mediated antibody evasion of highly infectious in vivo adapted HCV in humanised mice

      Prentø, Jannick, Verhoye, L., Moctezuma, R. V., Buysschaert, C., Farhoudi, A., Wang, R., Alter, H., Meuleman, P. & Bukh, Jens, Dec 2016, In: Gut. 65, 12, p. 1988-1997 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Hepatitis C Virus Genotype 1 to 6 Protease Inhibitor Escape Variants: In Vitro Selection, Fitness, and Resistance Patterns in the Context of the Infectious Viral Life Cycle.

      Serre, S., Jensen, S., Ghanem, L., Humes, D., Ramirez, S., Li, Y., Krarup, H., Bukh, Jens & Gottwein, Judith Margarete, Jun 2016, In: Antimicrobial Agents and Chemotherapy. 60, 6, p. 3563-3578 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Hepatitis C Virus Protease Inhibitors Show Differential Efficacy and Interactions with Remdesivir for Treatment of SARS-CoV-2 in Vitro

      Gammeltoft, Karen Anbro, Zhou, Y., Duarte Hernandez, C. R., Galli, Andrea, Offersgaard, Anna Falden, Costa, Rui, Pham, Long, Fahnøe, Ulrik, Feng, S., Scheel, Troels Kasper Høyer, Ramirez Almeida, Santseharay, Bukh, Jens & Gottwein, Judith Margarete, 2021, In: Antimicrobial Agents and Chemotherapy. 65, 9, e02680-20.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Hepatitis C Virus–Escape Studies for Human Monoclonal Antibody AR4A Reveal Isolate-Specific Resistance and a High Barrier to Resistance

      Velázquez-moctezuma, R., Galli, Andrea, Law, M., Bukh, Jens & Prentø, Jannick, 2019, In: The Journal of Infectious Diseases. 219, 1, p. 68-79

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Hepatitis C homolog in dogs with respiratory illness

      Bukh, Jens, 2011, In: PNAS Early Edition. 108, 31, p. 12563-4 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Hepatitis C hos hiv-inficerede patienter

      Bukh, Jens & Nielsen, J. O., 2006, In: Ugeskrift for læger. 168, 42, p. 3599-

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Hepatitis C virus RNA is 5'-capped with flavin adenine dinucleotide

      Sherwood, A. V., Rivera-Rangel, L. R., Ryberg, L. A., Larsen, H. S., Anker, K. M., Costa, R., Vågbø, C. B., Jakljevič, E., Pham, L. V., Fernandez-Antunez, C., Indrisiunaite, G., Podolska-Charlery, A., Grothen, J. E. R., Langvad, N. W., Fossat, N., Offersgaard, A., Al-Chaer, A., Nielsen, L., Kuśnierczyk, A., Sølund, C. & 8 others, Weis, Nina, Gottwein, Judith Margarete, Holmbeck, Kenn, Bottaro, S., Ramirez Almeida, Santseharay, Bukh, Jens, Scheel, Troels Kasper Høyer & Vinther, Jeppe, 2023, In: Nature. 619, p. 811-818

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Hepatitis C virus alters the morphology and function of peroxisomes

      Martin de Fourchambault, E., Callens, N., Saliou, J. M., Fourcot, M., Delos, O., Barois, N., Thorel, Q., Ramirez Almeida, Santseharay, Bukh, Jens, Cocquerel, L., Bertrand-Michel, J., Marot, G., Sebti, Y., Dubuisson, J. & Rouillé, Y., 2023, In: Frontiers in Microbiology. 14, 1254728.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Hepatitis C virus cell-cell transmission and resistance to direct-acting antiviral agents

      Xiao, F., Fofana, I., Heydmann, L., Barth, H., Soulier, E., Habersetzer, F., Doffoël, M., Bukh, Jens, Patel, A. H., Zeisel, M. B. & Baumert, T. F., May 2014, In: P L o S Pathogens. 10, 5, p. 1-15 16 p., e1004128.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Hepatitis C virus envelope protein dynamics and the link to hypervariable region 1

      Augestad, Elias Honerød, Bukh, Jens & Prentø, Jannick, 2021, In: Current Opinion in Virology. 50, p. 69-75 7 p.

      Research output: Contribution to journal › Review › Research › peer-review

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    ID: 12437