Kenn Holmbeck

Kenn Holmbeck

Associate Professor


  1. Published

    A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo

    Motley, M. P., Madsen, Daniel Hargbøl, Jürgensen, Henrik Jessen, Spencer, D. E., Szabo, R., Holmbeck, Kenn, Flick, M. J., Lawrence, D. A., Castellino, F. J., Weigert, R. & Bugge, T. H., 2016, In: Blood. 127, 9, p. 1085-1096 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    A regulatory cascade involving retinoic acid, Cbfa1, and matrix metalloproteinases is coupled to the development of a process of perichondrial invasion and osteogenic differentiation during bone formation

    Jiménez, M. J., Balbín, M., Alvarez, J., Komori, T., Bianco, P., Holmbeck, Kenn, Birkedal-Hansen, H., López, J. M. & López-Otín, C., 24 Dec 2001, In: The Journal of Cell Biology. 155, 7, p. 1333-44 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    An MT1-MMP-PDGF receptor-beta axis regulates mural cell investment of the microvasculature

    Lehti, K., Allen, E., Birkedal-Hansen, H., Holmbeck, Kenn, Miyake, Y., Chun, T. & Weiss, S. J., 15 Apr 2005, In: Genes & Development. 19, 8, p. 979-91 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published
  5. Published

    Aspects of extracellular matrix remodeling in development and disease

    Holmbeck, Kenn & Szabova, L., Mar 2006, In: Birth Defects Research. Part C: Embryo Today Reviews (Print). 78, 1, p. 11-23 13 p.

    Research output: Contribution to journalReviewResearch

  6. Biglycan modulates angiogenesis and bone formation during fracture healing

    Berendsen, A. D., Pinnow, E. L., Maeda, A., Brown, A. C., McCartney-Francis, N., Kram, V., Owens, R. T., Robey, P. G., Holmbeck, Kenn, de Castro, L. F., Kilts, T. M. & Young, M. F., Apr 2014, In: Matrix Biology. 35, p. 223-31 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Btbd7 is essential for region-specific epithelial cell dynamics and branching morphogenesis in vivo

    Daley, W. P., Matsumoto, K., Doyle, A. D., Wang, S., DuChez, B. J., Holmbeck, Kenn & Yamada, K. M., 2017, In: Development (Cambridge). 144, 12, p. 2200-2211 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Carcinomas contain a matrix metalloproteinase-resistant isoform of type I collagen exerting selective support to invasion

    Makareeva, E., Han, S., Vera, J. C., Sackett, D. L., Holmbeck, Kenn, Phillips, C. L., Visse, R., Nagase, H. & Leikin, S., 1 Jun 2010, In: Cancer Research. 70, 11, p. 4366-74 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Collagen dissolution by keratinocytes requires cell surface plasminogen activation and matrix metalloproteinase activity

    Netzel-Arnett, S., Mitola, D. J., Yamada, S. S., Chrysovergis, K., Holmbeck, Kenn, Birkedal-Hansen, H. & Bugge, T. H., 22 Nov 2002, In: The Journal of Biological Chemistry. 277, 47, p. 45154-61 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Collagenase in cranial morphogenesis

    Holmbeck, Kenn, 2005, In: Cells, Tissues, Organs. 181, 3-4, p. 154-65 12 p.

    Research output: Contribution to journalReviewResearch

  11. Published

    Complementary roles of intracellular and pericellular collagen degradation pathways in vivo

    Wagenaar-Miller, R. A., Engelholm, Lars Henning, Gavard, J., Yamada, S. S., Gutkind, J. S., Behrendt, Niels, Bugge, T. H. & Holmbeck, Kenn, Sep 2007, In: Molecular and Cellular Biology. 27, 18, p. 6309-22 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Constitutive expression of Gsα(R201C) in mice produces a heritable, direct replica of human fibrous dysplasia bone pathology and demonstrates its natural history

    Saggio, I., Remoli, C., Spica, E., Cersosimo, S., Sacchetti, B., Robey, P. G., Holmbeck, Kenn, Cumano, A., Boyde, A., Bianco, P. & Riminucci, M., 2014, In: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 29, 11, p. 2357-68 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Decreased demand for olfactory periglomerular cells impacts on neural precursor cell viability in the rostral migratory stream

    Langenfurth, A., Gu, S., Bautze, V., Zhang, C., Neumann, J. E., Schüller, U., Stock, K., Wolf, S. A., Maier, A., Mastrella, G., Pak, A., Cheng, H., Kälin, R. E., Holmbeck, Kenn, Strotmann, J., Kettenmann, H. & Glass, R., 30 Aug 2016, In: Scientific Reports. 6, 32203.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Development of craniofacial structures in transgenic mice with constitutively active PTH/PTHrP receptor

    Tsutsui, T. W., Riminucci, M., Holmbeck, Kenn, Bianco, P. & Robey, P. G., Feb 2008, In: Bone. 42, 2, p. 321-31 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Dimerization of endogenous MT1-MMP is a regulatory step in the activation of the 72-kDa gelatinase MMP-2 on fibroblasts and fibrosarcoma cells

    Ingvarsen, S. Z., Madsen, D. H., Hillig, T., Lund, L. R., Holmbeck, Kenn, Behrendt, Niels & Engelholm, L. H., 2008, In: Biological Chemistry. 389, 7, p. 943-953 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Establishment of high-titer HCV and SARS-CoV-2 production in a scalable packed-bed bioreactor for inactivated vaccines inducing neutralizing antibodies in animals

    Offersgaard, A. F., Hernandez, C. R. D., Finne Pihl, A., Feng, S., Marichal-Gallardo, P., Holmbeck, K., Venkatesan, N. P., Lin, X., Fernandez-Antunez, C., Pena Alzua, G., Costa, R., Hartmann, K. T., Pham, L., Zhou, Y., Gammeltoft, K. A., Fahnøe, U., Scheel, T. K. H., Schneider, U. V., Jensen, H. E., Christensen, J. P. & 5 others, Ramirez Almeida, Santseharay, Reichl, U., Genzel, Y., Bukh, J. & Gottwein, Judith Margarete, 6 Jul 2022.

    Research output: Contribution to conferenceConference abstract for conferenceCommunication

  17. Published

    Expression pattern of four membrane-type matrix metalloproteinases in the normal and diseased mouse mammary gland

    Szabova, L., Yamada, S. S., Birkedal-Hansen, H. & Holmbeck, Kenn, Oct 2005, In: Journal of Cellular Physiology. 205, 1, p. 123-32 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Extracellular collagenases and the endocytic receptor, urokinase plasminogen activator receptor-associated protein/Endo180, cooperate in fibroblast-mediated collagen degradation

    Madsen, Daniel Hargbøl, Engelholm, Lars Henning, Ingvarsen, S., Hillig, T., Wagenaar-Miller, R. A., Kjøller, L., Gårdsvoll, Henrik, Høyer-Hansen, G., Holmbeck, Kenn, Bugge, T. H. & Behrendt, Niels, 14 Sep 2007, In: The Journal of Biological Chemistry. 282, 37, p. 27037-45 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Fibroblast-derived MT1-MMP promotes tumor progression in vitro and in vivo

    Zhang, W., Matrisian, L. M., Holmbeck, Kenn, Vick, C. C. & Rosenthal, E. L., 6 Mar 2006, In: BMC Cancer. 6, p. 52

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Full-length sequence analysis of hepatitis C virus genotype 3b strains and development of an in vivo infectious 3b cDNA clone

    Bajpai, P. S., Collignon, Laura Maria F, Sølund, C., Madsen, L. W., Christensen, P. B., Øvrehus, A., Weis, Nina, Holmbeck, Kenn, Fahnøe, Ulrik & Bukh, Jens, 2023, In: Journal of Virology. 97, 12, 23 p., 00925.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    GNAS transcripts in skeletal progenitors: evidence for random asymmetric allelic expression of Gs alpha

    Michienzi, S., Cherman, N., Holmbeck, Kenn, Funari, A., Collins, M. T., Bianco, P., Robey, P. G. & Riminucci, M., 15 Aug 2007, In: Human Molecular Genetics. 16, 16, p. 1921-30 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Gelatinase A (MMP-2) activation by skin fibroblasts: dependence on MT1-MMP expression and fibrillar collagen form

    Ruangpanit, N., Chan, D., Holmbeck, Kenn, Birkedal-Hansen, H., Polarek, J., Yang, C., Bateman, J. F. & Thompson, E. W., Jun 2001, In: Matrix Biology. 20, 3, p. 193-203 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion

    Markovic, D. S., Vinnakota, K., Chirasani, S., Synowitz, M., Raguet, H., Stock, K., Sliwa, M., Lehmann, S., Kälin, R., van Rooijen, N., Holmbeck, Kenn, Heppner, F. L., Kiwit, J., Matyash, V., Lehnardt, S., Kaminska, B., Glass, R. & Kettenmann, H., 28 Jul 2009, In: Proceedings of the National Academy of Sciences of the United States of America. 106, 30, p. 12530-5 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Hepatitis C virus RNA is 5'-capped with flavin adenine dinucleotide

    Sherwood, A. V., Rivera-Rangel, L. R., Ryberg, L. A., Larsen, H. S., Anker, K. M., Costa, R., Vågbø, C. B., Jakljevič, E., Pham, L. V., Fernandez-Antunez, C., Indrisiunaite, G., Podolska-Charlery, A., Grothen, J. E. R., Langvad, N. W., Fossat, N., Offersgaard, A., Al-Chaer, A., Nielsen, L., Kuśnierczyk, A., Sølund, C. & 8 others, Weis, Nina, Gottwein, Judith Margarete, Holmbeck, Kenn, Bottaro, S., Ramirez Almeida, Santseharay, Bukh, Jens, Scheel, Troels Kasper Høyer & Vinther, Jeppe, 2023, In: Nature. 619, p. 811-818

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Inhibition of molar eruption and root elongation in MT1-MMP-deficient mice

    Beertsen, W., Holmbeck, Kenn, Niehof, A., Bianco, P., Chrysovergis, K., Birkedal-Hansen, H. & Everts, V., 2003, In: Connective Tissue Research. 44 Suppl 1, p. 298-9 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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ID: 164419721