Kei Sakamoto

Kei Sakamoto

Professor

Member of:


    1. 2021
    2. Published

      Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965

      Ahwazi, Danial, Neopane, K., Markby, G. R., Kopietz, F., Ovens, A. J., Dall, M., Hassing, Anna Skab, Gräsle, P., Alshuweishi, Y., Treebak, Jonas Thue, Salt, I. P., Göransson, O., Zeqiraj, E., Scott, J. W. & Sakamoto, Kei, 2021, In: Biochemical Journal. 478, 15, p. 2977-2997 21 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    3. Published

      Skeletal muscle

      Markby, G. R. & Sakamoto, Kei, 1 Jan 2021, Autophagy in Health and Disease. Elsevier, p. 213-225 13 p.

      Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

    4. 2022
    5. Published

      Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis

      Neopane, K., Kozlov, N., Negoita, F., Murray-Segal, L., Brink, R., Hoque, A., Ovens, A. J., Tjin, G., McAloon, L. M., Yu, D., Ling, N. X. Y., Sanders, M. J., Oakhill, J. S., Scott, J. W., Steinberg, G. R., Loh, K., Kemp, B. E., Sakamoto, Kei & Galic, S., 2022, In: Cell Reports. 41, 12, 26 p., 111862.

      Research output: Contribution to journalJournal articleResearchpeer-review

    6. Published

      Glucose-Dependent miR-125b Is a Negative Regulator of β-Cell Function

      Cheung, R., Pizza, G., Chabosseau, P., Rolando, D., Tomas, A., Burgoyne, T., Wu, Z., Salowka, A., Thapa, A., Macklin, A., Cao, Y., Nguyen-Tu, M. S., Dickerson, M. T., Jacobson, D. A., Marchetti, P., Shapiro, J., Piemonti, L., de Koning, E., Leclerc, I., Bouzakri, K. & 4 others, Sakamoto, Kei, Smith, D. M., Rutter, G. A. & Martinez-Sanchez, A., 2022, In: Diabetes. 71, 7, p. 1525-1545 21 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    7. Published

      Mechanism of glycogen synthase inactivation and interaction with glycogenin

      Marr, L., Biswas, Dipsikha, Daly, L. A., Browning, C., Vial, S. C. M., Maskell, D. P., Hudson, C., Bertrand, J. A., Pollard, J., Ranson, N. A., Khatter, H., Eyers, C. E., Sakamoto, Kei & Zeqiraj, E., 2022, In: Nature Communications. 13, 1, 14 p., 3372.

      Research output: Contribution to journalJournal articleResearchpeer-review

    8. Published

      Natural (dihydro)phenanthrene plant compounds are direct activators of AMPK through its allosteric drug and metabolite–binding site

      Sanders, M. J., Ratinaud, Y., Neopane, K., Bonhoure, N., Day, E. A., Ciclet, O., Lassueur, S., Pinta, M. N., Deak, M., Brinon, B., Christen, S., Steinberg, G. R., Barron, D. & Sakamoto, Kei, 2022, In: Journal of Biological Chemistry. 298, 5, 15 p., 101852.

      Research output: Contribution to journalJournal articleResearchpeer-review

    9. Published

      Opposing effects on regulated insulin secretion of acute vs chronic stimulation of AMP-activated protein kinase

      Nguyen-Tu, M., Harris, J., Martinez-Sanchez, A., Chabosseau, P., Hu, M., Georgiadou, E., Pollard, A., Otero, P., Lopez-Noriega, L., Leclerc, I., Sakamoto, Kei, Schmoll, D., Smith, D. M., Carling, D. & Rutter, G. A., 2022, In: Diabetologia. 65, p. 997-1011 15 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    10. Published

      PEN2: Metformin’s new partner at lysosome

      Sakamoto, Kei & Jessen, N., 2022, In: Cell Research. 32, p. 507-508

      Research output: Contribution to journalJournal articleResearchpeer-review

    11. Published

      The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids

      Desjardins, E. M., Smith, B. K., Day, E. A., Ducommun, S., Sanders, M. J., Nederveen, J. P., Ford, R. J., Pinkosky, S. L., Townsend, L. K., Gutgesell, R. M., Lu, R., Sakamoto, Kei & Steinberg, G. R., 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 48, 8 p., e2119824119.

      Research output: Contribution to journalJournal articleResearchpeer-review

    12. 2023
    13. Published

      AMPKα2 is a skeletal muscle stem cell intrinsic regulator of myonuclear accretion

      Kneppers, A., Ben Larbi, S., Theret, M., Saugues, A., Dabadie, C., Gsaier, L., Ferry, A., Rhein, P., Gondin, J., Sakamoto, Kei & Mounier, R., 2023, In: iScience. 26, 12, 17 p., 108343.

      Research output: Contribution to journalJournal articleResearchpeer-review

    ID: 227976158