Ole Thastrup
Emeritus
Administration and Operations
Jagtvej 160
2100 København Ø
- 1982
- Published
Coronary vasodilatory, spasmolytic and cAMP-Phosphodiesterase inhibitory properties of dihydropyranocoumarins and dihydrofuranocoumarins
Thastrup, Ole, Fjalland, B. & Lemmich, J., 1982, In: Planta Medica. 45, 3, p. 131Research output: Contribution to journal › Journal article › Research › peer-review
- 1983
- Published
Coronary vasodilatory, spasmolytic and cAMP-phosphodiesterase inhibitory properties of dihydropyranocoumarins and dihydrofuranocoumarins
Thastrup, Ole, Fjalland, B. & Lemmich, J., 1983, In: Acta pharmacologica et Toxicologica. 52, 4, p. 246-53 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1985
- Published
Inhibition of human platelet aggregation by dihydropyrano- and dihydrofuranocoumarins, a new class of cAMP-phosphodiesterase inhibitors
Thastrup, Ole, Knudsen, J. B., Lemmich, J. & Winther, K., 1985, In: Biochemical Pharmacology. 34, 12, p. 2137-40 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The ability of thapsigargin and thapsigargicin to activate cells involved in the inflammatory response
Ali, H., Christensen, Søren Brøgger, Foreman, J. C., Pearce, F. L., Piotrowski, W. & Thastrup, Ole, 1985, In: British Journal of Pharmacology. 85, 3, p. 705-12 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1987
Comparison of the action of calcium antagonists on basophil histamine release
Bindslev Jensen, C., Clementsen, P., Stahl Skov, P., Svendsen, U. G., Thastrup, Ole & Norn, S., 1987, In: Allergy: European Journal of Allergy and Clinical Immunology. 42, 6, p. 441-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Complexity of the influence of gangliosides on histamine release from human basophils and rat mast cells
Jensen, C., Svendsen, U. G., Thastrup, Ole, Stahl Skov, P., Leon, A. & Norn, S., 1987, In: Agents and Actions. 21, 1-2, p. 79-82 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Influence of nimodipine, verapamil and lanthanum on histamine release from human basophils: effect of pretreatment with sialidase
Jensen, C. B., Thastrup, Ole, Norn, S. & Skov, P. S., 1987, In: Pharmacology & Toxicology. 60, 3, p. 214-6 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibition of basophil histamine release by gangliosides. Further studies on the significance of cell membrane sialic acid in the histamine release process
Jensen, C., Norn, S., Thastrup, Ole, Dahl, B. T. & Skov, P. S., 1987, In: Allergy: European Journal of Allergy and Clinical Immunology. 42, 1, p. 51-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Membrane sialic acid influences basophil histamine release by interfering with calcium dependence
Jensen, C., Norn, S., Skov, P. S., Dahl, B. T., Thastrup, Ole, Leon, A. & Svendsen, U. G., 1987, In: Agents and Actions. 20, 3-4, p. 161-4 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The calcium mobilizing tumor promoting agent, thapsigargin elevates the platelet cytoplasmic free calcium concentration to a higher steady state level. A possible mechanism of action for the tumor promotion
Thastrup, Ole, Foder, B. & Scharff, O., 1987, In: Biochemical and Biophysical Research Communications. 142, 3, p. 654-60 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The inflammatory and tumor-promoting sesquiterpene lactone, thapsigargin, activates platelets by selective mobilization of calcium as shown by protein phosphorylations
Thastrup, Ole, Linnebjerg, H., Bjerrum, P. J., Knudsen, J. B. & Christensen, Søren Brøgger, 1987, In: BBA General Subjects. 927, 1, p. 65-73 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1988
A novel tumour promoter, thapsigargin, transiently increases cytoplasmic free Ca2+ without generation of inositol phosphates in NG115-401L neuronal cells
Jackson, T. R., Patterson, S. I., Thastrup, Ole & Hanley, M. R., 1988, In: Biochemical Journal. 253, 1, p. 81-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of thapsigargin on cytoplasmic Ca2+ and proliferation of human lymphocytes in relation to AIDS
Scharff, O., Foder, B., Thastrup, Ole, Hofmann, B., Møller, J., Ryder, L. P., Jacobsen, K. D., Langhoff, E., Dickmeiss, E. & Christensen, Søren Brøgger, 1988, In: BBA General Subjects. 972, 3, p. 257-64 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of thapsigargin in isolated rat thoracic aorta
Mikkelsen, E. O., Thastrup, Ole & Christensen, Søren Brøgger, 1988, In: Pharmacology & Toxicology. 62, 1, p. 7-11 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
Molecular mechanisms of phospholipid signaling pathways in mammalian nerve cells
Hanley, M. R., Jackson, T. R., Cheung, W. T., Dreher, M., Gatti, A., Hawkins, P., Patterson, S. I., Vallejo, M., Dawson, A. P. & Thastrup, Ole, 1988, In: Cold Spring Harbor Laboratory. Symposia on Quantitative Biology. 53, Pt 1, p. 435-45 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Neural function: metabolism and actions of inositol metabolites in mammalian brain
Hanley, M. R., Jackson, T. R., Vallejo, M., Patterson, S. I., Thastrup, Ole, Lightman, S., Rogers, J., Henderson, G. & Pini, A., 1988, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 320, 1199, p. 381-98 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1989
Activation of calcium entry by the tumor promoter thapsigargin in parotid acinar cells. Evidence that an intracellular calcium pool and not an inositol phosphate regulates calcium fluxes at the plasma membrane
Takemura, H., Hughes, A. R., Thastrup, Ole & Putney, J. W., 1989, In: Journal of Biological Chemistry. 264, 21, p. 12266-71 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Ca2+ transients and Mn2+ entry in human neutrophils induced by thapsigargin
Foder, B., Scharff, O. & Thastrup, Ole, 1989, In: Cell Calcium. 10, 7, p. 477-90 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
How do inositol phosphates regulate calcium signaling?
Putney, J. W., Takemura, H., Hughes, A. R., Horstman, D. A. & Thastrup, Ole, 1989, In: F A S E B Journal. 3, 8, p. 1899-905 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Internal Ca2+ mobilization and secretion in bovine adrenal chromaffin cells
Cheek, T. R. & Thastrup, Ole, 1989, In: Cell Calcium. 10, 4, p. 213-21 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Thapsigargin, a new calcium-dependent epithelial anion secretagogue
Brayden, D. J., Hanley, M. R., Thastrup, Ole & Cuthbert, A. W., 1989, In: British Journal of Pharmacology. 98, 3, p. 809-16 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1990
Calcium efflux across the plasma membrane of rat parotid acinar cells is unaffected by receptor activation or by the microsomal calcium ATPase inhibitor, thapsigargin
Takemura, H., Thastrup, Ole & Putney, J. W., 1990, In: Cell Calcium. 11, 1, p. 11-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Effects of MeCh, thapsigargin, and La3+ on plasmalemmal and intracellular Ca2+ transport in lacrimal acinar cells
Kwan, C. Y., Takemura, H., Obie, J. F., Thastrup, Ole & Putney, J. W., 1990, In: American Journal of Physiology (Consolidated). 258, 6 Pt 1, p. C1006-15Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Role of Ca2(+)-ATPases in regulation of cellular Ca2+ signalling, as studied with the selective microsomal Ca2(+)-ATPase inhibitor, thapsigargin
Thastrup, Ole, 1990, In: Agents and Actions. 29, 1-2, p. 8-15 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase
Thastrup, Ole, Cullen, P. J., Drøbak, B. K., Hanley, M. R. & Dawson, A. P., 1990, In: Proceedings of the National Academy of Sciences of the United States of America. 87, 7, p. 2466-70 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
Thapsigargin, but not caffeine, blocks the ability of thyrotropin-releasing hormone to release Ca2+ from an intracellular store in GH4C1 pituitary cells
Law, G. J., Pachter, J. A., Thastrup, Ole, Hanley, M. R. & Dannies, P. S., 1990, In: Biochemical Journal. 267, 2, p. 359-64 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Y1 receptors for neuropeptide Y are coupled to mobilization of intracellular calcium and inhibition of adenylate cyclase
Aakerlund, L., Gether, Ulrik, Fuhlendorff, J., Schwartz, Thue W. & Thastrup, Ole, 1990, In: F E B S Letters. 260, 1, p. 73-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
[Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist
Fuhlendorff, J., Gether, Ulrik, Aakerlund, L., Langeland-Johansen, N., Thøgersen, H., Melberg, S. G., Olsen, U. B., Thastrup, Ole & Schwartz, Thue W., 1990, In: Proceedings of the National Academy of Sciences of the United States of America. 87, 1, p. 182-6 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1991
Demonstration of two forms of calcium pumps by thapsigargin inhibition and radioimmunoblotting in platelet membrane vesicles
Papp, B., Enyedi, A., Kovács, T., Sarkadi, B., Wuytack, F., Thastrup, Ole, Gárdos, G., Bredoux, R., Levy-Toledano, S. & Enouf, J., 1991, In: Journal of Biological Chemistry. 266, 22, p. 14593-6 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Mobilization of calcium by inositol trisphosphates from permeabilized rat parotid acinar cells. Evidence for translocation of calcium from uptake to release sites within the inositol 1,4,5-trisphosphate- and thapsigargin-sensitive calcium pool
Menniti, F. S., Bird, G. S., Takemura, H., Thastrup, Ole, Potter, B. V. & Putney, J. W., 1991, In: Journal of Biological Chemistry. 266, 21, p. 13646-53 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Role of inositol (1,4,5)trisphosphate in epidermal growth factor-induced Ca2+ signaling in A431 cells
Hughes, A. R., Bird, G. S., Obie, J. F., Thastrup, Ole & Putney, J. W., 1991, In: Molecular Pharmacology. 40, 2, p. 254-62 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Stimulatory effect of thapsigargin, a non-TPA-type tumor promoter, on arachidonic acid metabolism in the murine keratinocyte line HEL30 and on epidermal cell proliferation in vivo as compared to the effects of phorbol ester TPA
Marks, F., Hanke, B., Thastrup, Ole & Fürstenberger, G., 1991, In: Carcinogenesis. 12, 8, p. 1491-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
The thapsigargin-sensitive intracellular Ca2+ pool is more important in plasma membrane Ca2+ entry than the IP3-sensitive intracellular Ca2+ pool in neuronal cell lines
Takemura, H., Ohshika, H., Yokosawa, N., Oguma, K. & Thastrup, Ole, 1991, In: Biochemical and Biophysical Research Communications. 180, 3, p. 1518-26 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1992
- Published
Biochemical and ultrastructural studies suggest that the effects of thapsigargin on human platelets are mediated by changes in intracellular calcium but not by intracellular histamine
Saxena, S. P., McNicol, A., Becker, A. B., Brandes, L. J., Thastrup, Ole & Gerrard, J. M., 1992, In: Thrombosis and Haemostasis. 68, 6, p. 714-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
In situ imaging of agonist-sensitive calcium pools in AR4-2J pancreatoma cells. Evidence for an agonist- and inositol 1,4,5-trisphosphate-sensitive calcium pool in or closely associated with the nuclear envelope
Glennon, M. C., Bird, G. S., Takemura, H., Thastrup, Ole, Leslie, B. A. & Putney, J. W., 1992, In: Journal of Biological Chemistry. 267, 35, p. 25568-75 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Mechanisms of activated Ca2+ entry in the rat pancreatoma cell line, AR4-2J
Bird, G. S., Takemura, H., Thastrup, Ole, Putney, J. W. & Menniti, F. S., 1992, In: Cell Calcium. 13, 1, p. 49-58 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
On the botanical distribution of chiral forms of gossypol
Jaroszewski, J. W., Strøm-Hansen, T., Hansen, S. H., Thastrup, Ole & Kofod, H., 1992, In: Planta Medica. 58, 5, p. 454-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The molluscicidal activity of coumarins from Ethulia conyzoides and of dicumarol
Kady, M. M., Brimer, L., Furu, Peter, Lemmich, E., Nielsen, H. M., Thiilborg, S. T., Thastrup, Ole & Christensen, Søren Brøgger, 1992, In: Planta Medica. 58, 4, p. 334-7 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1993
- Published
Structure-activity relationships of thapsigargin
Nielsen, S. F., Andersen, A., Olsen, C. E., Treimann, M., Thastrup, Ole & Christensen, Søren Brøgger, 1 Dec 1993, In: Planta Medica. 59, 7 SUPPL., p. A678-A679Research output: Contribution to journal › Journal article › Research › peer-review
- 1994
- Published
Characteristics of stably expressed human dopamine D1a and D1b receptors: atypical behavior of the dopamine D1b receptor
Pedersen, U. B., Norby, B., Jensen, Anders A., Schiødt, M., Hansen, A., Suhr-Jessen, P., Scheideler, M., Thastrup, Ole & Andersen, P. H., 1994, In: European Journal of Pharmacology. 267, 1, p. 85-93 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Thapsigargin: a novel molecular probe for studying intracellular calcium release and storage
Thastrup, Ole, Dawson, A. P., Scharff, O., Foder, B., Cullen, P. J., Drøbak, B. K., Bjerrum, P. J., Christensen, Søren Brøgger & Hanley, M. R., 1994, In: Agents and Actions. 43, 3-4, p. 187-93 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1995
- Published
Structure-activity relationships of analogues of thapsigargin modified at O-11 and O-12
Nielsen, S. F., Thastrup, Ole, Pedersen, R., Olsen, C. E. & Christensen, Søren Brøgger, 1995, In: Journal of Medicinal Chemistry. 38, 2, p. 272-6 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1996
Flow injection microscopy: a novel tool for the study of cellular response and drug discovery
Ruzicka, J., Baxter, P. J., Thastrup, Ole & Scudder, K., 1996, In: Analyst. 121, 7, p. 945-50 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1998
Signal transduction via the mitogen-activated protein kinase pathway induced by binding of coagulation factor VIIa to tissue factor
Poulsen, L. K., Jacobsen, N., Sørensen, B. B., Bergenhem, N. C., Kelly, J. D., Foster, D. C., Thastrup, Ole, Ezban, M. & Petersen, L. C., 1998, In: Journal of Biological Chemistry. 273, 11, p. 6228-32 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1999
Simultaneous visualization of the translocation of protein kinase Calpha-green fluorescent protein hybrids and intracellular calcium concentrations
Almholt, K., Arkhammar, P. O., Thastrup, Ole & Tullin, S., 1999, In: Biochemical Journal. 337 ( Pt 2), p. 211-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2000
Exclusion of known protease-activated receptors in factor VIIa-induced signal transduction
Petersen, L. C., Thastrup, Ole, Hagel, G., Sørensen, B. B., Freskgård, P. O., Rao, L. V. & Ezban, M., 2000, In: Thrombosis and Haemostasis. 83, 4, p. 571-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Separation of the glucose-stimulated cytoplasmic and mitochondrial NAD(P)H responses in pancreatic islet beta cells
Patterson, G. H., Knobel, S. M., Arkhammar, P., Thastrup, Ole & Piston, D. W., 2000, In: Proceedings of the National Academy of Sciences of the United States of America. 97, 10, p. 5203-7 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2001
Excitation wave propagation as a possible mechanism for signal transmission in pancreatic islets of Langerhans
Aslanidi, O. V., Mornev, O. A., Skyggebjerg, O., Arkhammar, P., Thastrup, Ole, Sørensen, M. P., Christiansen, P. L., Conradsen, K. & Scott, A. C., 2001, In: Biophysical Journal. 80, 3, p. 1195-209 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
Changes in intracellular cAMP reported by a Redistribution assay using a cAMP-dependent protein kinase-green fluorescent protein chimera
Almholt, K., Tullin, S., Skyggebjerg, O., Scudder, K., Thastrup, Ole & Terry, R., 2004, In: Cellular Signalling. 16, 8, p. 907-20 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Functional identification and monitoring of individual alpha and beta cells in cultured mouse islets of Langerhans
Hjortoe, G. M., Hagel, G. M., Terry, B. R., Thastrup, Ole & Arkhammar, P. O. G., 2004, In: Acta Diabetologica. 41, 4, p. 185-93 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 343169660
Most downloads
-
195
downloads
Short-term spheroid culture of primary colorectal cancer cells as an in vitro model for personalizing cancer medicine
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
151
downloads
Characterization of genetic intratumor heterogeneity in colorectal cancer and matching patient-derived spheroid cultures
Research output: Contribution to journal › Journal article › Research › peer-review
Published