Maiken Nedergaard

Maiken Nedergaard

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    1. Published

      PDGF-B Is Required for Development of the Glymphatic System

      Munk, A. S., Wang, W., Bèchet, N. B., Eltanahy, A. M., Cheng, A. X., Sigurdsson, B., Benraiss, A., Mäe, M. A., Kress, B. T., Kelley, D. H., Betsholtz, C., Møllgård, Kjeld, Meissner, A., Nedergaard, Maiken & Lundgaard, I., 2019, In: Cell Reports. 26, 11, p. 2955-2969.e3 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      A mesothelium divides the subarachnoid space into functional compartments

      Møllgård, Kjeld, Beinlich, Felix Ralf Michael, Kusk, P., Miyakoshi, L. M., Delle, Christine, Pla Requena, Virginia Teresa, Hauglund, Natalie Linea, Esmail, Tina, Rasmussen, Martin Kaag, Gomolka, Ryszard Stefan, Mori, Yuki & Nedergaard, Maiken, 2023, In: Science. 379, 6627, p. 84-885

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Lactate biosensors for spectrally and spatially multiplexed fluorescence imaging

      Nasu, Y., Aggarwal, A., Le, G. N. T., Vo, C. T., Kambe, Y., Wang, X., Beinlich, F. R. M., Lee, A. B., Ram, T. R., Wang, F., Gorzo, K. A., Kamijo, Y., Boisvert, M., Nishinami, S., Kawamura, G., Ozawa, T., Toda, H., Gordon, G. R., Ge, S., Hirase, H. & 5 others, Nedergaard, Maiken, Paquet, M. E., Drobizhev, M., Podgorski, K. & Campbell, R. E., 2023, In: Nature Communications. 14, 1, 17 p., 6598.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Secondary brain stem hemorrhage in stroke

      Nedergaard, Maiken, Klinken, L. & Paulson, Olaf B., 1 Jul 1983, In: Stroke. 14, 4, p. 501-5 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      The glymphatic system: reactive gliosis as a negative regulator

      Nedergaard, Maiken, 2019, In: Glia. 67, S1, p. E91 1 p., S26-02.

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    6. Published

      Glymphatic failure as a final common pathway to dementia

      Nedergaard, Maiken & Goldman, Steven Alan, 2020, In: Science (New York, N.Y.). 370, 6512, p. 50-56 7 p.

      Research output: Contribution to journal › Review › Research › peer-review

    7. Published

      Physiological Mechanisms and Significance of Intracranial B Waves

      Newell, D. W., Nedergaard, Maiken & Aaslid, R., 2022, In: Frontiers in Neurology. 13, 13 p., 872701.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Defining novel functions for cerebrospinal fluid in ALS pathophysiology

      Ng Kee Kwong, K. C., Mehta, A. R., Nedergaard, Maiken & Chandran, S., 2020, In: Acta Neuropathologica Communications. 8, 1, 18 p.

      Research output: Contribution to journal › Review › Research › peer-review

    9. Published

      Impaired Glymphatic Transport in Spontaneously Hypertensive Rats

      Nygaard Mortensen, K., Sanggaard, S., Mestre, H., Lee, H., Kostrikov, S., L R Xavier, Anna , Gjedde, Albert, Benveniste, H. & Nedergaard, Maiken, 2019, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 39, 32, p. 6365-6377 23 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Do Evolutionary Changes in Astrocytes Contribute to the Computational Power of the Hominid Brain?

      Oberheim Bush, N. A. & Nedergaard, Maiken, Sep 2017, In: Neurochemical Research. 42, 9, p. 2577-2587 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Astrocytic GPCR-Induced Ca2+ Signaling Is Not Causally Related to Local Cerebral Blood Flow Changes

      Ozawa, K., Nagao, Masaki, Konno, A., Iwai, Y., Vittani, Marta, Kusk, P., Mishima, Tsuneko, Hirai, H., Nedergaard, Maiken & Hirase, Hajime, 2023, In: International Journal of Molecular Sciences. 24, 17, 12 p., 13590.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Changes in visual processing during progression of Tau accumulation and neurodegeneration in a mouse model of human tauopathy

      Parka, A., Nedergaard, Maiken, Sotty, F. & Laursen, B., 2021, In: Investigative Ophthalmology & Visual Science. 62, 8, 3 p.

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    13. Published

      Visual Evoked Potentials as an Early-Stage Biomarker in the rTg4510 Tauopathy Mouse Model

      Parka, A., Volbracht, C., Hall, B., Bastlund, J. F., Nedergaard, Maiken, Laursen, B., Botta, P. & Sotty, F., 2023, In: Journal of Alzheimer's Disease. 93, 1, p. 247-262 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Early impairments of visually-driven neuronal ensemble dynamics in the rTg4510 tauopathy mouse model

      Parka, A., Degel, C., Dreyer, J., Richter, U., Hall, B., Bastlund, J. F., Laursen, B., Nedergaard, Maiken, Sotty, F. & Botta, P., 2023, In: Neurobiology of Disease. 178, 13 p., 106012.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      DNase treatment prevents CSF block in early experimental pneumococcal meningitis

      Pavan, C., L R Xavier, Anna , Ramos, M., Fisher, J., Kritsilis, M., Linder, A., Bentzer, P., Nedergaard, Maiken & Lundgaard, I., 2021, In: Annals of Neurology. 90, 4, p. 653-669 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Could dexmedetomidine be repurposed as a glymphatic enhancer?

      Persson, N. D. Å., Uusalo, P., Nedergaard, Maiken, Lohela, T. J. & Lilius, T. O., 2022, In: Trends in Pharmacological Sciences. 43, 12, p. 1030-1040 11 p.

      Research output: Contribution to journal › Review › Research › peer-review

    17. When the air hits your brain: Decreased arterial pulsatility after craniectomy leading to impaired glymphatic flow

      Plog, B. A., Lou, N., Pierre, C. A., Cove, A., Kenney, H. M., Hitomi, E., Kang, H., Iliff, J. J., Zeppenfeld, D. M., Nedergaard, Maiken & Vates, G. E., 2020, In: Journal of Neurosurgery. 133, 1, p. 210-223 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      An unnoticed player overseeing CSF flux

      Pla Requena, Virginia Teresa & Nedergaard, Maiken, 2022, In: Nature Cardiovascular Research. 1, 2 p.

      Research output: Contribution to journal › Comment/debate › Research

    19. Published

      Structural characterization of SLYM—a 4th meningeal membrane

      Pla Requena, Virginia Teresa, Bitsika, S., Giannetto, M. J., Ladron-de-Guevara, A., Gahn-Martinez, D., Mori, Yuki, Nedergaard, Maiken & Møllgård, Kjeld, 2023, In: Fluids and Barriers of the CNS. 20, 1, 18 p., 93.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      A real-time in vivo clearance assay for quantification of glymphatic efflux

      Plá, V., Bork, Peter Aleksander Rousing, Harnpramukkul, A., Olveda, G., Ladrón-de-Guevara, A., Giannetto, M. J., Hussain, R., Wang, W., Kelley, D. H., Hablitz, L. M. & Nedergaard, Maiken, 2022, In: Cell Reports. 40, 11, 20 p., 111320.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Bulk flow of cerebrospinal fluid observed in periarterial spaces is not an artifact of injection

      Raghunandan, A., Ladron-De-guevara, A., Tithof, J., Mestre, H., Du, T., Nedergaard, Maiken, Thomas, J. H. & Kelley, D. H., 2021, In: eLife. 10, 15 p., e65958.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Cardiovascular brain impulses in Alzheimer's disease

      Rajna, Z., Mattila, H., Huotari, N., Tuovinen, T., Krüger, J., Holst, S. C., Korhonen, V., Remes, A. M., Seppänen, T., Hennig, J., Nedergaard, Maiken & Kiviniemi, V., 2021, In: Brain. 144, 7, p. 2214-2226 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Cisterna magna injection in rats to study glymphatic function

      Ramos, M., Burdon Bechet, N., Battistella, R., Pavan, C., L R Xavier, Anna , Nedergaard, Maiken & Lundgaard, I., 2019, Astrocytes: Methods and Protocols. Di Benedetto, B. (ed.). Humana Press, p. 97-104 8 p. (Methods in Molecular Biology, Vol. 1938).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    24. Published

      Twists and turns of ocular glymphatic clearance – new study reveals surprising findings in glaucoma

      Rangroo Thrane, V., Hynnekleiv, L., Wang, X., Thrane, A. S., Krohn, J. & Nedergaard, Maiken, 2021, In: Acta Ophthalmologica. 99, 2, p. e283-e284 2 p.

      Research output: Contribution to journal › Letter › Research › peer-review

    25. Published

      The glymphatic pathway in neurological disorders

      Rasmussen, Martin Kaag, Mestre, H. & Nedergaard, Maiken, 2018, In: The Lancet Neurology. 17, 11, p. 1016-1024 9 p.

      Research output: Contribution to journal › Review › Research › peer-review

    26. Published

      Fluid Transport in the Brain

      Rasmussen, Martin Kaag, Mestre, H. & Nedergaard, Maiken, 2022, In: Physiological Reviews. 102, p. 1025-1151 27 p.

      Research output: Contribution to journal › Review › Research › peer-review

    27. Published

      Interstitial ions: A key regulator of state-dependent neural activity?

      Rasmussen, R., O'Donnell, J., Ding, F. & Nedergaard, Maiken, 2020, In: Progress in Neurobiology. 98, 101802.

      Research output: Contribution to journal › Review › Research › peer-review

    28. Published

      Cortex-wide Changes in Extracellular Potassium Ions Parallel Brain State Transitions in Awake Behaving Mice

      Rasmussen, R., Nicholas, E., Petersen, Nicolas Caesar, Dietz, Andrea Grostøl, Xu, Q., Sun, Q. & Nedergaard, Maiken, 2019, In: Cell Reports. 28, 5, p. 1182-1194 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Sulforhodamine 101, a widely used astrocyte marker, can induce cortical seizure-like activity at concentrations commonly used

      Rasmussen, R., Nedergaard, Maiken & Petersen, Nicolas Caesar, 2016, In: Scientific Reports. 6, 9 p., 30433.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Glymphatic System Impairment in Alzheimer's Disease and Idiopathic Normal Pressure Hydrocephalus

      Reeves, B. C., Karimy, J. K., Kundishora, A. J., Mestre, H., Cerci, H. M., Matouk, C., Alper, S. L., Lundgaard, I., Nedergaard, Maiken & Kahle, K. T., 2020, In: Trends in Molecular Medicine. 26, 3, p. 285-295 11 p.

      Research output: Contribution to journal › Review › Research › peer-review

    31. Published

      A Distinct Population of Microglia Supports Adult Neurogenesis in the Subventricular Zone

      Ribeiro Xavier, A. L., Kress, B. T., Goldman, Steven Alan, Lacerda de Menezes, J. R. & Nedergaard, Maiken, 26 Aug 2015, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 35, 34, p. 11848-11861 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      SPECT imaging of the glymphatic pathway with In-111-labeled ovalbumin in the rat brain

      Shalgunov, Vladimir, Lilius, T., Sigurosson, B., Baerentzen, S. L., Hauglund, Natalie Linea, Herth, Matthias Manfred, Palner, M. & Nedergaard, Maiken, 2019, In: Journal of Labelled Compounds and Radiopharmaceuticals. 62, Supplement 1, p. S404-S405 2 p.

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    33. Published

      Brain Segmentation in Rodent MR-Images Using Convolutional Neural Networks

      Sigurdsson, B., Darkner, Sune, Sommer, Stefan Horst, Mortensen, K. N., Sanggaard, S., Kostrikov, S. & Nedergaard, Maiken, 2018.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    34. Published

      A SPECT-based method for dynamic imaging of the glymphatic system in rats

      Sigurdsson, B., Hauglund, Natalie Linea, Lilius, T. O., Mogensen, F. L. H., Mortensen, K. N., Beschorner, Natalie, Klinger, L., Bærentzen, S. L., Rosenholm, Marko, Shalgunov, Vladimir, Herth, Matthias Manfred, Mori, Yuki & Nedergaard, Maiken, 2023, In: Journal of Cerebral Blood Flow and Metabolism. 43, 7, 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Astrocytic Endocannabinoids Mediate Hippocampal Transient Heterosynaptic Depression

      Smith, N. A., Bekar, L. K. & Nedergaard, Maiken, 2020, In: Neurochemical Research. 45, 1, p. 100-108 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Mapping of CSF transport using high spatiotemporal resolution dynamic contrast-enhanced MRI in mice: Effect of anesthesia

      Stanton, E. H., Persson, N. D. Å., Gomolka, Ryszard Stefan, Lilius, T., Sigurðsson, B., Lee, H., L R Xavier, Anna , Benveniste, H., Nedergaard, Maiken & Mori, Yuki, 2021, In: Magnetic Resonance in Medicine. 85, 6, p. 3326-3342 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Development of 11C-labeled CRANAD-102 for positron emission tomography imaging of soluble Aβ-species

      Staudt, Markus, Shalgunov, Vladimir, Nedergaard, Maiken & Herth, Matthias Manfred, 2023, In: Journal of Labelled Compounds and Radiopharmaceuticals. 66, 12, p. 393-399

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      A three-dimensional, population-based average of the C57BL/6 mouse brain from DAPI-stained coronal slices

      Stæger, Frederik Filip Vinggaard, Mortensen, K. N., Nielsen, M. S. N., Sigurdsson, B., Kaufmann, L. K., Hirase, Hajime & Nedergaard, Maiken, 2020, In: Scientific Data. 7, 1, 7 p., 235.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      SOX9 is an astrocyte-specific nuclear marker in the adult brain outside the neurogenic regions

      Sun, W., Cornwell, A., Li, J., Peng, S., Joana Osorio, M., Aalling, Nadia, Wang, S., Benraiss, A., Lou, N., Goldman, Steven Alan & Nedergaard, Maiken, 2017, In: Journal of Neuroscience. 37, 17, p. 4493-4507 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy

      Sweeney, A. M., Pla, V., Du, T., Liu, G., Sun, Q., Peng, S., Plog, B. A., Kress, B. T., Wang, X., Mestre, H. & Nedergaard, Maiken, 2019, In: Journal of Visualized Experiments. 149, 7 p., e59774.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Vascular dysfunction-The disregarded partner of Alzheimer's disease

      Sweeney, M. D., Montagne, A., Sagare, A. P., Nation, D. A., Schneider, L. S., Chui, H. C., Harrington, M. G., Pa, J., Law, M., Wang, D. J. J., Jacobs, R. E., Doubal, F. N., Ramirez, J., Black, S. E., Nedergaard, M., Benveniste, H., Dichgans, M., Iadecola, C., Love, S., Bath, P. M. & 49 others, Markus, H. S., Salman, R. A., Allan, S. M., Quinn, T. J., Kalaria, R. N., Werring, D. J., Carare, R. O., Touyz, R. M., Williams, S. C. R., Moskowitz, M. A., Katusic, Z. S., Lutz, S. E., Lazarov, O., Minshall, R. D., Rehman, J., Davis, T. P., Wellington, C. L., Gonzalez, H. M., Yuan, C., Lockhart, S. N., Hughes, T. M., Chen, C. L. H., Sachdev, P., O'Brien, J. T., Skoog, I., Pantoni, L., Gustafson, D. R., Biessels, G. J., Wallin, A., Smith, E. E., Mok, V., Wong, A., Passmore, P., Barkof, F., Muller, M., Breteler, M. M. B., Roman, G. C., Hamel, E., Seshadri, S., Gottesman, R. F., van Buchem, M. A., Arvanitakis, Z., Schneider, J. A., Drewes, L. R., Hachinski, V., Finch, C. E., Toga, A. W., Wardlaw, J. M. & Zlokovic, B. V., 2019, In: Alzheimers & Dementia. 15, 1, p. 158-167

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      A network model of glymphatic flow under different experimentally-motivated parametric scenarios

      Tithof, J., Boster, K. A. S., Bork, Peter Aleksander Rousing, Nedergaard, Maiken, Thomas, J. H. & Kelley, D. H., 2022, In: iScience. 25, 5, 24 p., 104258.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Astrocytic chloride is brain state dependent and modulates inhibitory neurotransmission in mice

      Untiet, Verena, Beinlich, Felix Ralf Michael, Kusk, P., Kang, N., Ladrón-de-Guevara, A., Song, W., Kjærby, Celia, Andersen, Mie, Hauglund, Natalie Linea, Bojarowska, Zuzanna, Sigurdsson, B., Deng, S., Hirase, Hajime, Petersen, Nicolas Caesar, Verkhratsky, A. & Nedergaard, Maiken, 2023, In: Nature Communications. 14, 1, 14 p., 1871.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Astrocyte chloride, excitatory-inhibitory balance and epilepsy

      Untiet, Verena, Nedergaard, Maiken & Verkhratsky, A., 2024, In: Neural Regeneration Research. 19, 9, p. 1887-1887 1 p.

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    45. Published

      Physiology of astroglia

      Verkhratsky, A. & Nedergaard, Maiken, 2018, In: Physiological Reviews. 98, 1, p. 239-389 151 p.

      Research output: Contribution to journal › Review › Research › peer-review

    46. Published

      Editorial: Sleep and Mood Disorders

      Verkhratsky, A., Nedergaard, Maiken, Steardo, L. & Li, B., 2020, In: Frontiers in Psychiatry. 10, 3 p., 981.

      Research output: Contribution to journal › Editorial › Research › peer-review

    47. Published

      The homeostatic astroglia emerges from evolutionary specialization of neural cells

      Verkhratsky, A. & Nedergaard, Maiken, 5 Aug 2016, In: Royal Society of London. Philosophical Transactions B. Biological Sciences. 371, 1700, p. 1-11 11 p., 20150428.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Astrocytic connexin 43 potentiates myelin injury in ischemic white matter disease

      Wang, M., Qin, C., Luo, X., Wang, J., Wang, X., Xie, M., Hu, J., Cao, J., Hu, T., Goldman, Steven Alan, Nedergaard, Maiken & Wang, W., 2019, In: Theranostics. 9, 15, p. 4474-4493 20 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts

      Wang, M., Ding, F., Deng, S., Guo, X., Wang, W., Iliff, J. J. & Nedergaard, Maiken, 15 Mar 2017, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 37, 11, p. 2870-2877 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      An ocular glymphatic clearance system removes beta-amyloid from the rodent eye

      Wang, X., Lou, N., Eberhardt, A., Yang, Y., Kusk, P., Xu, Q., Forstera, B., Peng, S., Shi, M., Ladron-de-Guevara, A., Delle, Christine, Sigurdsson, B., L R Xavier, Anna , Erturk, A., Libby, R. T., Chen, L., Thrane, A. S. & Nedergaard, Maiken, 2020, In: Science Translational Medicine. 12, 536, eaaw3210.

      Research output: Contribution to journal › Journal article › Research › peer-review

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