Cord Herbert Brakebusch

Cord Herbert Brakebusch

ORCID: 0000-0002-9342-1634

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  1. Published

    CDC42 Deletion Elicits Cerebral Vascular Malformations via Increased MEKK3-Dependent KLF4 Expression

    Castro, M., Laviña, B., Ando, K., Álvarez-Aznar, A., Abu Taha, A., Brakebusch, Cord Herbert, Dejana, E., Betsholtz, C. & Gaengel, K. B., 2019, In: Circulation Research. 124, 8, p. 1240-1252 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    The Interaction between Laminin-332 and α3β1 Integrin Determines Differentiation and Maintenance of CAFs, and Supports Invasion of Pancreatic Duct Adenocarcinoma Cells

    Cavaco, A. C. M., Rezaei, M., Caliandro, M. F., Lima, A. M., Stehling, M., Dhayat, S. A., Haier, J., Brakebusch, Cord Herbert & Eble, J. A., 2019, In: Cancers. 11, 1, p. 1-20 20 p., 14.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Mice lacking desmocollin 1 show epidermal fragility accompanied by barrier defects and abnormal differentiation.

    Chidgey, M., Brakebusch, Cord Herbert, Gustafsson, E., Cruchley, A., Hail, C., Kirk, S., Merritt, A., North, A., Tselepis, C., Hewitt, J., Byrne, C., Fassler, R. & Garrod, D., 2001, In: Journal of Cell Biology. 155, 5, p. 821-32 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Redundant and nonredundant roles for Cdc42 and Rac1 in lymphomas developed in NPM-ALK transgenic mice

    Choudhari, R., Minero, V. G., Menotti, M., Pulito, R., Brakebusch, Cord Herbert, Compagno, M., Voena, C., Ambrogio, C. & Chiarle, R., 10 Mar 2016, In: Blood. 127, 10, p. 1297-306 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Rac1 is crucial for hair follicle integrity but is not essential for maintenance of the epidermis.

    Chrostek, A., Wu, X., Quondamatteo, F., Hu, R., Sanecka, A., Niemann, C., Langbein, L., Haase, I. & Brakebusch, Cord Herbert, 2006, In: Molecular and Cellular Biology. 26, 18, p. 6957-70 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    beta1-integrin-mediated signaling essentially contributes to cell survival after radiation-induced genotoxic injury.

    Cordes, N., Seidler, J., Durzok, R., Geinitz, H. & Brakebusch, Cord Herbert, 2006, In: Oncogene. 25, 9, p. 1378-90 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Cdc42 is not essential for filopodium formation, directed migration, cell polarization, and mitosis in fibroblastoid cells.

    Czuchra, A., Wu, X., Meyer, H., van Hengel, J., Schroeder, T., Geffers, R., Rottner, K. & Brakebusch, Cord Herbert, 2005, In: Molecular Biology of the Cell. 16, 10, p. 4473-84 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Genetic analysis of beta1 integrin "activation motifs" in mice.

    Czuchra, A., Meyer, H., Legate, K. R., Brakebusch, Cord Herbert & Fässler, R., 2006, In: Journal of Cell Biology. 174, 6, p. 889-99 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    The fibronectin-binding integrins alpha5beta1 and alphavbeta3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis.

    Danen, E. H. J., Sonneveld, P., Brakebusch, Cord Herbert, Fassler, R. & Sonnenberg, A., 2002, In: Journal of Cell Biology. 159, 6, p. 1071-86 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Increased levels of apoptosis in the prefusion neural folds underlie the craniofacial disorder, Treacher Collins syndrome.

    Dixon, J., Brakebusch, Cord Herbert, Fässler, R. & Dixon, M. J., 2000, In: Human Molecular Genetics. 9, 10, p. 1473-80 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    RhoH is important for positive thymocyte selection and T-cell receptor signaling.

    Dorn, T., Kuhn, U., Bungartz, G., Stiller, S., Bauer, M., Ellwart, J., Peters, T., Scharffetter-Kochanek, K., Semmrich, M., Laschinger, M., Holzmann, B., Klinkert, W. E. F., Straten, P. T., Køllgaard, T., Sixt, M. & Brakebusch, Cord Herbert, 2006, In: Blood. 109, 6, p. 2346-55 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Cdc42 is crucial for the maturation of primordial cell junctions in keratinocytes independent of Rac1

    Du, D., Pedersen, E., Wang, Z., Karlsson, R., Chen, Z., Wu, X. & Brakebusch, Cord Herbert, 2008, In: Experimental Cell Research.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    RhoA Controls Axon Extension Independent of Specification in the Developing Brain

    Dupraz, S., Hilton, B. J., Husch, A., Santos, T. E., Coles, C. H., Stern, S., Brakebusch, Cord Herbert & Bradke, F., 18 Nov 2019, In: Current biology : CB. 29, 22, p. 3874-3886 22 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis

    Dütting, S., Gaits-Iacovoni, F., Stegner, D., Popp, M., Antkowiak, A., Van Eeuwijk, J. M. M., Nurden, P., Stritt, S., Heib, T., Aurbach, K., Angay, O., Cherpokova, D., Heinz, N., Baig, A. A., Gorelashvili, M. G., Gerner, F., Heinze, K. G., Ware, J., Krohne, G., Ruggeri, Z. M. & 6 others, Nurden, A. T., Schulze, H., Modlich, U., Pleines, I., Brakebusch, Cord Herbert & Nieswandt, B., 15 Jun 2017, In: Nature Communications. 8, 13 p., 15838.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Critical off-target effects of the widely used Rac1 inhibitors NSC23766 and EHT1864 in mouse platelets

    Dütting, S., Heidenreich, J., Cherpokova, D., Amin, E., Zhang, S., Ahmadian, M. R., Brakebusch, Cord Herbert & Nieswandt, B., May 2015, In: Journal of Thrombosis and Haemostasis. 13, 5, p. 827-38 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Cdc42 regulates epithelial cell polarity and cytoskeletal function during kidney tubule development

    Elias, B. C., Das, A., Parekh, D. V., Mernaugh, G., Adams, R., Yang, Z., Brakebusch, Cord Herbert, Pozzi, A., Marciano, D. K., Carroll, T. J. & Zent, R., 1 Dec 2015, In: Journal of Cell Science. 128, 23, p. 4293-305 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Antibodies to a soluble form of a tumor necrosis factor (TNF) receptor have TNF-like activity.

    Engelmann, H., Holtmann, H., Brakebusch, Cord Herbert, Avni, Y. S., Sarov, I., Nophar, Y., Hadas, E., Leitner, O. & Wallach, D., 1990, In: Journal of Biological Chemistry. 265, 24, p. 14497-504 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Stage-specific control of neural crest stem cell proliferation by the small rho GTPases Cdc42 and Rac1

    Fuchs, S., Herzog, D., Sumara, G., Büchmann-Møller, S., Civenni, G., Wu, X., Chrostek-Grashoff, A., Suter, U., Ricci, R., Relvas, J. B., Brakebusch, Cord Herbert & Sommer, L., 2009, In: Cell Stem Cell. 4, 3, p. 236-47 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    90K (MAC-2 BP) gene expression in breast cancer and evidence for the production of 90K by peripheral-blood mononuclear cells.

    Fusco, O., Querzoli, P., Nenci, I., Natoli, C., Brakebusch, Cord Herbert, Ullrich, A. & Iacobelli, S., 1998, In: International Journal of Cancer. 79, 1, p. 23-6 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Loss of RhoA promotes skin tumor formation and invasion by upregulation of RhoB

    García-Mariscal, A., Li, H., Pedersen, E., Peyrollier, K., Ryan, K. M., Stanley, A., Quondamatteo, F. & Brakebusch, Cord Herbert, 15 Feb 2018, In: Oncogene. 37, 7, p. 847-860 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    RhoA Controls Retinoid Signaling by ROCK Dependent Regulation of Retinol Metabolism

    García-Mariscal, A., Peyrollier, K., Basse, A., Pedersen, E. D. K., Rühl, R., van Hengel, J. & Brakebusch, Cord Herbert, 2018, In: Small GTPases. 9, 5, p. 433–444

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Cdc42 regulates cofilin during the establishment of neuronal polarity.

    Garvalov, B. K., Flynn, K. C., Neukirchen, D., Meyn, L., Teusch, N., Wu, X., Brakebusch, Cord Herbert, Bamburg, J. R. & Bradke, F., 2007, In: Journal of Neuroscience. 27, 48, p. 13117-29 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    RhoA, Rac1, and Cdc42 differentially regulate αSMA and collagen I expression in mesenchymal stem cells

    Ge, J., Burnier, L., Adamopoulou, M., Kwa, M. Q., Schaks, M., Rottner, K. & Brakebusch, Cord Herbert, 2018, In: The Journal of Biological Chemistry. 293, 24, p. 9358-9369 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Maintaining resting cardiac fibroblasts in vitro by disrupting mechanotransduction

    Gilles, G., McCulloch, A. D., Brakebusch, Cord Herbert & Herum, K. M., 2020, In: PLoS ONE. 15, 10, p. 1-13 e0241390.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Induction of cell scattering by expression of beta1 integrins in beta1-deficient epithelial cells requires activation of members of the rho family of GTPases and downregulation of cadherin and catenin function.

    Gimond, C., van Der Flier, A., van Delft, S., Brakebusch, Cord Herbert, Kuikman, I., Collard, J. G., Fässler, R. & Sonnenberg, A., 1999, In: Journal of Cell Biology. 147, 6, p. 1325-40 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    A new genetic tool to improve immune-compromised mouse models: Derivation and CRISPR/Cas9-mediated targeting of NRG embryonic stem cell lines

    Martin Gonzalez, Javier, Baudet, A., Abelechian, Sahar, Bonderup, K., d'Altri, T., Porse, Bo Torben, Brakebusch, Cord Herbert, Juliusson, G. & Cammenga, J., 2018, In: Genesis: The Journal of Genetics and Development (Print). 56, 9, p. 1-7 7 p., e23238.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair.

    Grose, R., Hutter, C., Bloch, W., Thorey, I., Watt, F. M., Fässler, R., Brakebusch, Cord Herbert & Werner, S., 2002, In: Development. 129, 9, p. 2303-15 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Multiple integrin-ligand interactions synergize in shear-resistant platelet adhesion at sites of arterial injury in vivo.

    Grüner, S., Prostredna, M., Schulte, V., Krieg, T., Eckes, B., Brakebusch, Cord Herbert & Nieswandt, B., 2003, In: Blood. 102, 12, p. 4021-7 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Tie-1-directed expression of Cre recombinase in endothelial cells of embryoid bodies and transgenic mice.

    Gustafsson, E., Brakebusch, Cord Herbert, Hietanen, K. & Fässler, R., 2001, In: Journal of Cell Science. 114, Pt 4, p. 671-6 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Role of the beta1-integrin cytoplasmic tail in mediating invasin-promoted internalization of Yersinia.

    Gustavsson, A., Armulik, A., Brakebusch, Cord Herbert, Fässler, R., Johansson, S. & Fällman, M., 2002, In: Journal of Cell Science. 115, Pt 13, p. 2669-78 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Functions of Rac1 in the epidermis

    Haase, I. & Brakebusch, Cord Herbert, 2008, In: Journal of Investigative Dermatology. 128, Suppl. 1

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    A central role for the small GTPase Rac1 in hippocampal plasticity and spatial learning and memory

    Haditsch, U., Leone, D. P., Farinelli, M., Chrostek-Grashoff, A., Brakebusch, Cord Herbert, Mansuy, I. M., McConnell, S. K. & Palmer, T. D., 2009, In: Molecular and Cellular Neuroscience. 41, 4, p. 409-19 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Neuronal Rac1 is required for learning-evoked neurogenesis

    Haditsch, U., Anderson, M. P., Freewoman, J., Cord, B., Babu, H., Brakebusch, Cord Herbert & Palmer, T. D., 24 Jul 2013, In: Journal of Neuroscience. 33, 30, p. 12229-41 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Rac1 is essential for basement membrane-dependent epiblast survival

    He, X., Liu, J., Qi, Y., Brakebusch, Cord Herbert, Chrostek-Grashoff, A., Edgar, D., Yurchenco, P. D., Corbett, S. A., Lowry, S. F., Graham, A. M., Han, Y. & Li, S., 2010, In: Molecular and Cellular Biology. 30, 14, p. 3569-81 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    None of the integrins known to be present on the mouse egg or to be ADAM receptors are essential for sperm-egg binding and fusion.

    He, Z., Brakebusch, Cord Herbert, Fässler, R., Kreidberg, J. A., Primakoff, P. & Myles, D. G., 2003, In: Developmental Biology. 254, 2, p. 226-37 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    RhoA/Cdc42 signaling drives cytoplasmic maturation but not endomitosis in megakaryocytes

    Heib, T., Hermanns, H. M., Manukjan, G., Englert, M., Kusch, C., Becker, I. C., Gerber, A., Wackerbarth, L. M., Burkard, P., Dandekar, T., Balkenhol, J., Jahn, D., Beck, S., Meub, M., Dütting, S., Stigloher, C., Sauer, M., Cherpokova, D., Schulze, H., Brakebusch, C. & 3 others, Nieswandt, B., Nagy, Z. & Pleines, I., 2021, In: Cell Reports. 35, 6, p. 109102 1 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Hepatocyte dysplasia and tumor nodule formation in CDC42-deficient mouse liver

    Hengel, J. V., D'Hooge, P., Wu, X. W., Libbrecht, L., Vos, R. D., Brakebusch, Cord Herbert & Roy, F. V., 2008, In: Acta Clinica Belgica. 63, 1, p. 56-56

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Distinct roles for dystroglycan, beta1 integrin and perlecan in cell surface laminin organization.

    Henry, M. D., Satz, J. S., Brakebusch, Cord Herbert, Costell, M., Gustafsson, E., Fässler, R. & Campbell, K. P., 2001, In: Journal of Cell Science. 114, Pt 6, p. 1137-44 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Syndecan-4 Protects the Heart From the Profibrotic Effects of Thrombin-Cleaved Osteopontin

    Herum, K. M., Romaine, A., Wang, A., Melleby, A. O., Strand, M. E., Pacheco, J., Braathen, B., Dunér, P., Tønnessen, T., Lunde, I. G., Sjaastad, I., Brakebusch, Cord Herbert, McCulloch, A. D., Gomez, M. F., Carlson, C. R. & Christensen, G., 2020, In: Journal of the American Heart Association. 9, 3, 31 p., e013518.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Cardiac fibroblast sub-types in vitro reflect pathological cardiac remodeling in vivo

    Herum, K. M., Weng, Guangzheng, Kahnert, Konstantin, Waikel, R., Milburn, G., Conger, A., Anaya, P., Campbell, K. S., Lundby, Alicia, Won, K. J. & Brakebusch, Cord Herbert, 2022, In: Matrix Biology Plus. 15, 100113.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    The small GTPase RhoA is required to maintain spinal cord neuroepithelium organization and the neural stem cell pool

    Herzog, D., Loetscher, P., van Hengel, J., Knüsel, S., Brakebusch, Cord Herbert, Taylor, V., Suter, U. & Relvas, J. B., 30 Mar 2011, In: Journal of Neuroscience. 31, 13, p. 5120-30 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Mechanisms controlling the level of receptors for tumor necrosis factor.

    Holtmann, H., Brakebusch, Cord Herbert, König, M., Klocke, R., Winzen, R., Resch, K. & Wallach, D., 1991, In: Agents and Actions. 32, 1-2, p. 106-8 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Expression and cytoprotective activity of the small GTPase RhoB induced by the Escherichia coli cytotoxic necrotizing factor 1

    Huelsenbeck, S. C., Roggenkamp, D., May, M., Huelsenbeck, J., Brakebusch, Cord Herbert, Rottner, K., Ladwein, M., Just, I., Fritz, G., Schmidt, G. & Genth, H., Aug 2013, In: International Journal of Biochemistry & Cell Biology. 45, 8, p. 1767-75 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    The cysteine-rich domain of human ADAM 12 supports cell adhesion through syndecans and triggers signaling events that lead to beta1 integrin-dependent cell spreading.

    Iba, K., Albrechtsen, Reidar, Gilpin, B., Frohlich, C., Loechel, F., Zolkiewska, A., Ishiguro, K., Kojima, T., Liu, W., Langford, J. K., Sanderson, R. D., Brakebusch, Cord Herbert, Fässler, R. & Wewer, Ulla M., 2000, In: Journal of Cell Biology. 149, 5, p. 1143-56 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes

    Jackson, B., Peyrollier, K., Pedersen, E., Basse, A., Karlsson, R., Wang, Z., Lefever, T., Ochsenbein, A. M., Schmidt, G., Aktories, K., Stanley, A., Quondamatteo, F., Ladwein, M., Rottner, K., van Hengel, J. & Brakebusch, Cord Herbert, 1 Mar 2011, In: Molecular Biology of the Cell. 22, 5, p. 593-605 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Suppression of tumor growth in vivo by local and systemic 90K level increase.

    Jallal, B., Powell, J., Zachwieja, J., Brakebusch, Cord Herbert, Germain, L., Jacobs, J., Iacobelli, S. & Ullrich, A., 1995, In: Cancer Research. 55, 15, p. 3223-7 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    RhoA determines disease progression by controlling neutrophil motility and restricting hyperresponsiveness

    Jennings, R. T., Strengert, M., Hayes, P., El-Benna, J., Brakebusch, Cord Herbert, Kubica, M. & Knaus, U. G., 29 Apr 2014, In: Blood. 123, 23, p. 3635-45 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    FMNL formins boost lamellipodial force generation

    Kage, F., Winterhoff, M., Dimchev, V., Mueller, J., Thalheim, T., Freise, A., Brühmann, S., Kollasser, J., Block, J., Dimchev, G. A., Geyer, M., Schnittler, H., Brakebusch, Cord Herbert, Stradal, T. E. B., Carlier, M., Sixt, M., Käs, J., Faix, J. & Rottner, K., 22 Mar 2017, In: Nature Communications. 8, 16 p., 14832.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Author Correction: FMNL2 and -3 regulate Golgi architecture and anterograde transport downstream of Cdc42

    Kage, F., Steffen, A., Ellinger, A., Ranftler, C., Gehre, C., Brakebusch, Cord Herbert, Pavelka, M., Stradal, T. & Rottner, K., 26 Nov 2019, In: Scientific Reports. 9, 1, p. 18008 1 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  50. Published

    FMNL2 and -3 regulate Golgi architecture and anterograde transport downstream of Cdc42

    Kage, F., Steffen, A., Ellinger, A., Ranftler, C., Gehre, C., Brakebusch, Cord Herbert, Pavelka, M., Stradal, T. & Rottner, K., 1 Dec 2017, In: Scientific Reports. 7, 1, 17 p., 9791.

    Research output: Contribution to journal › Journal article › Research › peer-review

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