Christoffer Clemmensen

Christoffer Clemmensen

Associate Professor

ORCID: 0000-0003-2456-9667

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  1. Published

    A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

    Finan, B., Yang, B., Ottaway, N., Smiley, D. L., Ma, T., Clemmensen, C., Chabenne, J., Zhang, L., Habegger, K. M., Fischer, K., Campbell, J. E., Sandoval, D., Seeley, R. J., Bleicher, K., Uhles, S., Riboulet, W., Funk, J., Hertel, C., Belli, S., Sebokova, E. & 9 others, Conde-Knape, K., Konkar, A., Drucker, D. J., Gelfanov, V., Pfluger, P. T., Müller, T. D., Perez-Tilve, D., DiMarchi, R. D. & Tschöp, M. H., Jan 2015, In: Nature Medicine. 21, 1, p. 27-36 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Emerging opportunities for the treatment of metabolic diseases: Glucagon-like peptide-1 based multi-agonists

    Finan, B., Clemmensen, Christoffer & Müller, T. D., 2015, In: Molecular and Cellular Endocrinology. 418 Pt 1, p. 42-54 13 p.

    Research output: Contribution to journal › Review › Research › peer-review

  3. Published

    Chemical hybridization of glucagon and thyroid hormone optimizes therapeutic impact for metabolic disease

    Finan, B., Clemmensen, C., Zhu, Z., Stemmer, K., Gauthier, K., Müller, L., De Angelis, M., Moreth, K., Neff, F., Perez-Tilve, D., Fischer, K., Lutter, D., Sánchez-Garrido, M. A., Liu, P., Tuckermann, J., Malehmir, M., Healy, M. E., Weber, A., Heikenwalder, M., Jastroch, M. & 22 others, Kleinert, Maximilian, Jall, S., Brandt, S., Flamant, F., Schramm, K. W., Biebermann, H., Döring, Y., Weber, C., Habegger, K. M., Keuper, M., Gelfanov, V., Liu, F., Köhrle, J., Rozman, J., Fuchs, H., Gailus-Durner, V., Hrabě de Angelis, M., Hofmann, S. M., Yang, B., Tschöp, M. H., Dimarchi, R. & Müller, T. D., 2016, In: Cell. 167, 3, p. 843-857.e1-e14 29 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Reappraisal of GIP Pharmacology for Metabolic Diseases

    Finan, B., Müller, T. D., Clemmensen, Christoffer, Perez-Tilve, D., DiMarchi, R. D. & Tschöp, M. H., May 2016, In: Trends in Molecular Medicine. 22, 5, p. 359-76 18 p.

    Research output: Contribution to journal › Review › Research › peer-review

  5. Published

    The Pentapeptide RM-131 Promotes Food Intake and Adiposity in Wildtype Mice but Not in Mice Lacking the Ghrelin Receptor

    Fischer, K., Finan, B., Clemmensen, Christoffer, van der Ploeg, L. H. T., Tschöp, M. H. & Müller, T. D., 2014, In: Frontiers in Nutrition. 1, p. 31

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation

    Fischer, K., Fenzl, A., Liu, D., Dyar, K. A., Kleinert, M., Brielmeier, M., Clemmensen, C., Fedl, A., Finan, B., Gessner, A., Jastroch, M., Huang, J., Keipert, S., Klingenspor, M., Brüning, J. C., Kneilling, M., Maier, F. C., Othman, A. E., Pichler, B. J., Pramme-Steinwachs, I. & 13 others, Sachs, S., Scheideler, A., Thaiss, W. M., Uhlenhaut, H., Ussar, S., Woods, S. C., Zorn, J., Stemmer, K., Collins, S., Diaz-Meco, M., Moscat, J., Tschöp, M. H. & Müller, T. D., 2020, In: Nature Communications. 11, 1, 13 p., 2306.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis

    Fischer, K., Ruiz, H. H., Jhun, K., Finan, B., Oberlin, D. J., van der Heide, V., Kalinovich, A. V., Petrovic, N., Wolf, Y., Clemmensen, C., Shin, A. C., Divanovic, S., Brombacher, F., Glasmacher, E., Keipert, S., Jastroch, M., Nagler, J., Schramm, K-W., Medrikova, D., Collden, G. & 9 others, Woods, S. C., Herzig, S., Homann, D., Jung, S., Nedergaard, J., Cannon, B., Tschöp, M. H., Müller, T. D. & Buettner, C., May 2017, In: Nature Medicine. 23, 5, p. 623-630 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Extreme duration exercise affects old and younger men differently

    Frandsen, J., Sahl, R. E., Rømer, T., Thunestvedt Hansen, M., Nielsen, A. B., Lie-Olesen, M. M., Rasmusen, H. K., Søgaard, D., Ingersen, A., Rosenkilde, M., Westerterp, K., Holst, J. J., Andersen, J. L., Markowski, A. R., Blachnio-Zabielska, A., Clemmensen, C., Sacchetti, M., Cataldo, A., Traina, M., Larsen, S. & 2 others, Dela, Flemming & Helge, Jørn Wulff, 2022, In: Acta Physiologica. 235, 3, e13816.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Discovery of thymosin β4 as a human exerkine and growth factor

    Gonzalez-Franquesa, A., Stocks, Ben Nicholas, Borg, M. L., Kuefner, M., Kellezi, Emilie Dalbram, Nielsen, Thomas Svava, Agrawal, A., Pankratova, Stanislava, Chibalin, A. V., Karlsson, H. K. R., Gheibi, S., Björnholm, M., Jørgensen, Niklas Rye, Clemmensen, Christoffer, Treebak, Jonas Thue, Hostrup, Morten, Krook, A., Zierath, Juleen R & Deshmukh, Atul Shahaji, 2021, In: American Journal of Physiology: Cell Physiology. 321, 5, p. C770-C778 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Beta-Hydroxybutyrate Suppresses Hepatic Production of the Ghrelin Receptor Antagonist LEAP2

    Holm, Stephanie Kjærulff, Husted, Anna Sofie, Skov, Louise Julie, Morville, T. H., Hagemann, C. A., Jorsal, T., Dall, M., Jakobsen, A., Klein, A. B., Treebak, Jonas Thue, Knop, Filip Krag, Schwartz, Thue W., Clemmensen, Christoffer & Holst, Birgitte, 2022, In: Endocrinology. 163, 6, 13 p., bqac038.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Ketone monoester increases circulating levels of LEAP2 and decreases appetite in healthy men

    Holm, Stephanie Kjærulff, Vestergaard, E. T., Zubanovic, N. B., Byberg, Sarah, Clemmensen, Christoffer, Holst, Birgitte & Thomsen, H. H., 2023, In: Diabetes, Obesity and Metabolism. 25, 7, p. :2023–2027

    Research output: Contribution to journal › Letter › Research › peer-review

  12. Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice

    Jall, S., Sachs, S., Clemmensen, Christoffer, Finan, B., Neff, F., DiMarchi, R. D., Tschöp, M. H., Müller, T. D. & Hofmann, S. M., May 2017, In: Molecular Metabolism. 6, 5, p. 440-446 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Pharmacological targeting of α3β4 nicotinic receptors improves peripheral insulin sensitivity in mice with diet-induced obesity

    Jall, S., De Angelis, M., Lundsgaard, Anne-Marie, Fritzen, Andreas Mæchel, Nicolaisen, T. S., Klein, A. B., Novikoff, A., Sachs, S., Richter, Erik A., Kiens, Bente, Schramm, K., Tschöp, M. H., Stemmer, K., Clemmensen, Christoffer, Müller, T. D. & Kleinert, Maximilian, 2020, In: Diabetologia. 63, 6, p. 1236-1247 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Pirt deficiency has subtle female-specific effects on energy and glucose metabolism in mice

    Jall, S., Finan, B., Collden, G., Fischer, K., Dong, X., Tschoep, M. H., Mueller, T. D. & Clemmensen, Christoffer, 2019, In: Molecular Metabolism. 23, p. 75-81

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Hypothalamic leptin action is mediated by histone deacetylase 5

    Kabra, D. G., Pfuhlmann, K., García-Cáceres, C., Schriever, S. C., Casquero García, V., Kebede, A. F., Fuente-Martin, E., Trivedi, C., Heppner, K., Uhlenhaut, N. H., Legutko, B., Kabra, U. D., Gao, Y., Yi, C-X., Quarta, C., Clemmensen, C., Finan, B., Müller, T. D., Meyer, C. W., Paez-Pereda, M. & 7 others, Stemmer, K., Woods, S. C., Perez-Tilve, D., Schneider, R., Olson, E. N., Tschöp, M. H. & Pfluger, P. T., 29 Feb 2016, In: Nature Communications. 7, 10782.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Dietary medium-chain fatty acids reduce food intake via the GDF15-GFRAL axis in mice

    Kanta, Josephine Maria, Deisen, L., Johann, K., Holm, Stephanie Kjærulff, Lundsgaard, Anne-Marie, Lund, Jens, Jähnert, M., Schürmann, A., Clemmensen, Christoffer, Kiens, Bente, Fritzen, Andreas Mæchel & Kleinert, Maximilian, 2023, In: Molecular Metabolism. 74, 10 p., 101760.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    The GDF15-GFRAL pathway is dispensable for the effects of metformin on energy balance

    Klein, A. B., Nicolaisen, T. S., Johann, K., Fritzen, Andreas Mæchel, Mathiesen, C. V., Gil, Cláudia, Pilmark, N. S., Karstoft, Kristian, Blond, Martin Bæk, Quist, Jonas Salling, Seeley, R. J., Færch, K., Lund, Jens, Kleinert, Maximilian & Clemmensen, Christoffer, 2022, In: Cell Reports. 40, 8, 111258.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Cross-species comparison of pregnancy-induced GDF15

    Klein, A. B., Ranea-Robles, Pablo, Nicolaisen, T. S., Gil, Cláudia, Johann, K., Prats Quesada, Júlia, Pistoljevic, N., Hviid, K. V. R., Olsen, L. F., Offersen, Simone Margaard, Helge, Jørn Wulff, Nielsen, Henriette Svarre, Bakker, J., Kleinert, Maximilian & Clemmensen, Christoffer, 2023, In: American Journal of Physiology - Endocrinology and Metabolism. 325, 4, p. E303-E309

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise

    Klein, A. B., Nicolaisen, T. S., Ørtenblad, N., Gejl, K. D., Jensen, R., Fritzen, A. M., Larsen, E. L., Karstoft, K., Poulsen, H. E., Morville, T., Sahl, R. E., Helge, J. W., Lund, J., Falk, S., Lyngbæk, M., Ellingsgaard, H., Pedersen, B. K., Lu, W., Finan, B., Jørgensen, S. B. & 5 others, Seeley, R. J., Kleinert, Maximilian, Kiens, Bente, Richter, Erik A. & Clemmensen, Christoffer, 2021, In: Nature Communications. 12, 9 p., 1041.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    GDF15 in appetite and exercise: Essential player or coincidental bystander?

    Klein, A. B., Kleinert, Maximilian, Richter, Erik A. & Clemmensen, Christoffer, 2022, In: Endocrinology. 163, 1, p. 1-10 10 p.

    Research output: Contribution to journal › Review › Research › peer-review

  21. Published

    Emerging poly-agonists for obesity and type 2 diabetes

    Kleinert, Maximilian, Clemmensen, Christoffer, Stemmer, K., Müller, T. D., DiMarchi, R. D. & Tschöp, M. H., 2017, In: Obesity. 25, 10, p. 1647-1649 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Exercise increases circulating GDF15 in humans

    Kleinert, Maximilian, Clemmensen, Christoffer, Sjøberg, K. A., Carl, Christian Strini, Jeppesen, J. F., Wojtaszewski, Jørgen F P, Kiens, Bente & Richter, Erik A., 2018, In: Molecular Metabolism. 9, p. 187-191 5 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  23. Published

    Animal models of obesity and diabetes mellitus

    Kleinert, Maximilian, Clemmensen, Christoffer, Hofmann, S. M., Moore, M. C., Renner, S., Woods, S. C., Huypens, P., Beckers, J., de Angelis, M. H., Schürmann, A., Bakhti, M., Klingenspor, M., Heiman, M., Cherrington, A. D., Ristow, M., Lickert, H., Wolf, E., Havel, P. J., Müller, T. D. & Tschöp, M. H., 2018, In: Nature Reviews Endocrinology. 14, p. 140-162 23 p.

    Research output: Contribution to journal › Review › Research › peer-review

  24. Published

    Time-resolved hypothalamic open flow micro-perfusion reveals normal leptin transport across the blood–brain barrier in leptin resistant mice

    Kleinert, Maximilian, Kotzbeck, P., Altendorfer-Kroath, T., Birngruber, T., Tschöp, M. H. & Clemmensen, Christoffer, 2018, In: Molecular Metabolism. 13, p. 77-82 6 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  25. Published

    Effect of bariatric surgery on plasma GDF15 in humans

    Kleinert, Maximilian, Bojsen-Møller, K. N., Jørgensen, N. B., Svane, M. S., Martinussen, C., Kiens, Bente, Wojtaszewski, Jørgen F P, Madsbad, Sten, Richter, Erik A. & Clemmensen, Christoffer, 2019, In: American Journal of Physiology: Endocrinology and Metabolism. 316, 4, p. E615-E621 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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