Thomas Werge
Clinical Professor
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Genetic disposition towards educational attainment and intelligence test performance predict voter turnout
Aaroe, L., Appadurai, V., Hansen, Kasper Møller, Schork, A. J., Werge, Thomas, Mors, O., Borglum, A. D., Hougaard, D. M., Nordentoft, Merete, Mortensen, P. B., Thompson, W. K., Buil, A., Agerbo, E. & Petersen, M. B., 2021, In: Nature Human Behavior. 5, 2, p. 281-291 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Risk of Early-Onset Depression Associated With Polygenic Liability, Parental Psychiatric History, and Socioeconomic Status
Agerbo, E., Trabjerg, B. B., Børglum, A. D., Schork, A. J., Vilhjálmsson, B. J., Pedersen, C. B., Hakulinen, C., Albiñana, C., Hougaard, D. M., Grove, J., McGrath, J. J., Bybjerg-Grauholm, J., Mors, O., Plana-Ripoll, O., Werge, Thomas, Wray, N. R., Mortensen, P. B. & Musliner, K. L., 2021, In: JAMA Psychiatry. 78, 4, p. 387-397 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Leveraging both individual-level genetic data and GWAS summary statistics increases polygenic prediction
Albiñana, C., Grove, J., McGrath, J. J., Agerbo, E., Wray, N. R., Bulik, C. M., Nordentoft, Merete, Hougaard, D. M., Werge, Thomas, Børglum, A. D., Mortensen, P. B., Privé, F. & Vilhjálmsson, B. J., 2021, In: American Journal of Human Genetics. 108, 6, p. 1001-1011 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Association of polygenic score for major depression with response to lithium in patients with bipolar disorder
Amare, A. T., Schubert, K. O., Hou, L., Clark, S. R., Papiol, S., Cearns, M., Heilbronner, U., Degenhardt, F., Tekola-Ayele, F., Hsu, Y. H., Shekhtman, T., Adli, M., Akula, N., Akiyama, K., Ardau, R., Arias, B., Aubry, J. M., Backlund, L., Bhattacharjee, A. K., Bellivier, F. & 46 others, , 2021, In: Molecular Psychiatry. 26, p. 2457–2470 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders
Andlauer, T. F. M., Guzman-Parra, J., Streit, F., Strohmaier, J., González, M. J., Gil Flores, S., Cabaleiro Fabeiro, F. J., del Río Noriega, F., Perez, F. P., Haro González, J., Orozco Diaz, G., de Diego-Otero, Y., Moreno-Küstner, B., Auburger, G., Degenhardt, F., Heilmann-Heimbach, S., Herms, S., Hoffmann, P., Frank, J., Foo, J. C. & 26 others, , 2021, In: Molecular Psychiatry. 26, 4, p. 1286-1298 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis
Bell, S., Rigas, A. S., Magnusson, M. K., Ferkingstad, E., Allara, E., Bjornsdottir, G., Ramond, A., Sørensen, E., Halldorsson, G. H., Paul, D. S., Burgdorf, K. S., Eggertsson, H. P., Howson, J. M. M., Thørner, L. W., Kristmundsdottir, S., Astle, W. J., Erikstrup, C., Sigurdsson, J. K., Vuckovic, D., Dinh, K. M. & 31 others, , 2021, In: Communications Biology . 4, 1, 14 p., 156.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic, Clinical, and Sociodemographic Factors Associated With Stimulant Treatment Outcomes in ADHD
Brikell, I., Wimberley, T., Albinana, C., Pedersen, E. M., Vilhjalmsson, B. J., Agerbo, E., Demontis, D., Borglum, A. D., Schork, A. J., LaBianca, S., Werge, Thomas, Mors, O., Hougaard, D. M., Thapar, A., Mortensen, P. B. & Dalsgaard, S., 2021, In: American Journal of Psychiatry. 178, 9, p. 854-864 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genome-wide association study identifies 48 common genetic variants associated with handedness
Cuellar-Partida, G., Tung, J. Y., Eriksson, N., Albrecht, E., Aliev, F., Andreassen, O. A., Barroso, I., Beckmann, J. S., Boks, M. P., Boomsma, D. I., Boyd, H. A., Breteler, M. M. B., Campbell, H., Chasman, D. I., Cherkas, L. F., Davies, G., de Geus, E. J. C., Deary, I. J., Deloukas, P., Dick, D. M. & 98 others, , 2021, In: Nature Human Behaviour. 5, p. 59-70Research output: Contribution to journal › Journal article › Research › peer-review
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Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder
Demontis, D., Walters, R. K., Rajagopal, V. M., Waldman, I. D., Grove, J., Als, T. D., Dalsgaard, S., Ribasas, M., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Werge, T., Nordentoft, M., Mors, O., Mortensen, P. B., Andreassen, O. A., Arranz, M. J., Banaschewski, T., Bau, C., Bellgrove, M., Biederman, J. & 31 others, , 2021, In: Nature Communications. 12, 576.Research output: Contribution to journal › Journal article › Research › peer-review
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Impact of COVID-19 Pandemic on Sleep Quality, Stress Level and Health-Related Quality of Life - A Large Prospective Cohort Study on Adult Danes
Didriksen, Maria, Werge, Thomas, Nissen, J., Schwinn, M., Sørensen, E., Nielsen, K. R., Bruun, M. T., Banasik, Karina, Hansen, T. F., Erikstrup, C., Ostrowski, Sisse Rye, Jennum, Poul, Hjalgrim, Henrik, Ullum, H. & Pedersen, Ole Birger Vesterager, 2021, In: International Journal of Environmental Research and Public Health. 18, 14, 14 p., 7610.Research output: Contribution to journal › Journal article › Research › peer-review
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Gestational age-dependent development of the neonatal metabolome
Ernst, M., Rogers, S., Lausten-Thomsen, U., Björkbom, A., Laursen, S. S., Courraud, J., Borglum, A., Nordentoft, Merete, Werge, Thomas, Mortensen, P. B., Hougaard, D. M. & Cohen, A. S., 2021, In: Pediatric Research. 89, p. 1396–1404 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic regulation of spermine oxidase activity and cancer risk: a Mendelian randomization study
Fadista, J., Yakimov, V., Võsa, U., Hansen, C. S., Kasela, S., Skotte, L., Geller, F., Courraud, J., Esko, T., Kukuškina, V., Buil, A., Melbye, M., Werge, Thomas, Hougaard, D. M., Milani, L., Bybjerg-Grauholm, J., Cohen, A. S. & Feenstra, B., 2021, In: Scientific Reports. 11, 17463.Research output: Contribution to journal › Journal article › Research › peer-review
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Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression
Forstner, A. J., Awasthi, S., Wolf, C., Maron, E., Erhardt, A., Czamara, D., Eriksson, E., Lavebratt, C., Allgulander, C., Friedrich, N., Becker, J., Hecker, J., Rambau, S., Conrad, R., Geiser, F., Mcmahon, F. J., Moebus, S., Hess, T., Buerfent, B. C., Hoffmann, P. & 55 others, , 2021, In: Molecular Psychiatry. 26, p. 4179–4190 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genome-wide association study across pediatric central nervous system tumors implicates shared predisposition and points to 1q25.2 (PAPPA2) and 11p12 (LRRC4C) as novel candidate susceptibility loci
Foss-Skiftesvik, J., Hagen, C. M., Mathiasen, R., Adamsen, D., Bækvad-Hansen, M., Børglum, A. D., Nordentoft, Merete, Werge, Thomas, Christiansen, M., Schmiegelow, Kjeld, Juhler, Marianne, Mortensen, P. B., Hougaard, D. M. & Bybjerg-Grauholm, J., 2021, In: Child's Nervous System. 37, p. 819–830Research output: Contribution to journal › Journal article › Research › peer-review
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Transcriptomic networks implicate neuronal energetic abnormalities in three mouse models harboring autism and schizophrenia-associated mutations
Gordon, A., Forsingdal, A., Klewe, I. V., Nielsen, J., Didriksen, M., Werge, Thomas & Geschwind, D. H., 2021, In: Molecular Psychiatry. 26, p. 1520–1534Research output: Contribution to journal › Journal article › Research › peer-review
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Identifying dominant-negative actions of a dopamine transporter variant in patients with parkinsonism and neuropsychiatric disease
Herborg, F., Jensen, K. L., Tolstoy, S., Arends, N., Posselt, L. P., Shekar, A., Aguilar, J., Lund, V. K., Erreger, K., Rickhag, M., Lycas, M. D., Lonsdale, M. N., Rahbek-Clemmensen, T., Sorensen, A. T., Newman, A. H., Lokkegaard, A., Kjaerulff, O., Werge, T., Moller, L. B., Matthies, H. J. G. & 4 others, , 2021, In: JCI insight. 6, 18, 21 p., 151496.Research output: Contribution to journal › Journal article › Research › peer-review
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A polygenic resilience score moderates the genetic risk for schizophrenia
Hess, J. L., Tylee, D. S., Mattheisen, M., The Schizophrenia Working Group of the Psychiatric Genomics Consortium, Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Børglum, A. D., Als, T. D., Grove, J., Werge, T., Mortensen, P. B., Mors, O., Nordentoft, M., Hougaard, D. M., Byberg-grauholm, J., Bækvad-hansen, M., Greenwood, T. A., Tsuang, M. T., Curtis, D., Steinberg, S., Sigurdsson, E. & 6 others, , 2021, In: Molecular Psychiatry. 26, p. 800–815Research output: Contribution to journal › Journal article › Research › peer-review
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No evidence of associations between genetic liability for schizophrenia and development of cannabis use disorder
Hjorthøj, Carsten, Uddin, M. J., Wimberley, T., Dalsgaard, S., Hougaard, D. M., Borglum, A., Werge, Thomas & Nordentoft, Merete, 2021, In: Psychological Medicine. 51, 3, p. 479-484 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Relationship Between Major Depressive Disorder (Mdd) Symptoms and Mdd Heterogeneity
Huang, L., Tang, S., Krebs, M. D., Schork, A. J., Werge, Thomas, Dahl, A., Zuber, V. & Cai, N., 2021, In: Genetic Epidemiology. 45, 7, p. 761-761 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Identification of genetic loci associated with nocturnal enuresis: a genome-wide association study
Jørgensen, C. S., Horsdal, H. T., Rajagopal, V. M., Grove, J., Als, T. D., Kamperis, K., Nyegaard, M., Walters, G. B., Eðvarðsson, V. Ö., Stefánsson, H., Nordentoft, M., Hougaard, D. M., Werge, T., Mors, O., Mortensen, P. B., Agerbo, E., Rittig, S., Stefánsson, K., Børglum, A. D., Demontis, D. & 1 others, , 2021, In: The Lancet Child & Adolescent Health. 5, 3, p. 201-209Research output: Contribution to journal › Journal article › Research › peer-review
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Associations between patterns in comorbid diagnostic trajectories of individuals with schizophrenia and etiological factors
Krebs, M. D., Themudo, G. E., Benros, Michael Eriksen, Mors, O., Børglum, A. D., Hougaard, D., Mortensen, P. B., Nordentoft, Merete, Gandal, M. J., Fan, C. C., Geschwind, D. H., Schork, A. J., Werge, Thomas & Thompson, W. K., 2021, In: Nature Communications. 12, 12 p., 6617.Research output: Contribution to journal › Journal article › Research › peer-review
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Copy Number Variants and Polygenic Risk Scores Predict Need of Care in Autism and/or ADHD Families
LaBianca, S., LaBianca, J., Pagsberg, Anne Katrine, Jakobsen, K. D., Appadurai, V., Buil, A. & Werge, Thomas, Jan 2021, In: Journal of Autism and Developmental Disorders. 51, 1, p. 276-285 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic factors underlying the bidirectional relationship between autoimmune and mental disorders - findings from a Danish population-based study: [Incl. Corrigendum]
Liu, X., Nudel, R., Thompson, W. K., Appadurai, V., Schork, A. J., Buil, A., Rasmussen, Simon, Allesøe, R. L., Werge, Thomas, Mors, O., Børglum, A. D., Hougaard, D. M., Mortensen, P. B., Nordentoft, Merete & Benros, Michael Eriksen, 2021, In: Brain, Behavior, and Immunity. 91, p. 10-23 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pharmacogenetic genotype and phenotype frequencies in a large Danish population-based case-cohort sample
Lunenburg, C. A. T. C., Thirstrup, J. P., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Hougaard, D. M., Nordentoft, Merete, Werge, Thomas, Børglum, A. D., Mors, O., Mortensen, P. B. & Gasse, C., 2021, In: Translational Psychiatry. 11, 1, 294.Research output: Contribution to journal › Journal article › Research › peer-review
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Examining Sex-Differentiated Genetic Effects Across Neuropsychiatric and Behavioral Traits
Martin, J., Khramtsova, E. A., Goleva, S. B., Blokland, G. A. M., Traglia, M., Walters, R. K., Hübel, C., Coleman, J. R. I., Breen, G., Børglum, A. D., Demontis, D., Grove, J., Werge, T., Bralten, J., Bulik, C. M., Lee, P. H., Mathews, C. A., Peterson, R. E., Winham, S. J., Wray, N. & 13 others, , 2021, In: Biological Psychiatry. 89, 12, p. 1127-1137Research output: Contribution to journal › Journal article › Research › peer-review
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The genetic structure of Norway
Mattingsdal, M., Ebenesersdóttir, S. S., Moore, K. H. S., Andreassen, O. A., Hansen, Thomas Folkmann, Werge, Thomas, Kockum, I., Olsson, T., Alfredsson, L., Helgason, A., Stefánsson, K. & Hovig, E., 2021, In: European Journal of Human Genetics. 29, p. 1710–1718Research output: Contribution to journal › Journal article › Research › peer-review
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Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
HUNT All-In Psychiatry, H. A. P., 2021, In: Nature Genetics. 53, 6, p. 817-829 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Co-occurring hydrocephalus in autism spectrum disorder: a Danish population-based cohort study
Munch, Tina Nørgaard, Hedley, P. L., Hagen, C. M., Bækvad-Hansen, M., Bybjerg-Grauholm, J., Grove, J., Nordentoft, Merete, Børglum, A. D., Mortensen, P. B., Werge, Thomas, Melbye, M., Hougaard, D. M. & Christiansen, M., 2021, In: Journal of Neurodevelopmental Disorders. 13, 9 p., 19.Research output: Contribution to journal › Journal article › Research › peer-review
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A large-scale investigation into the role of classical HLA loci in multiple types of severe infections, with a focus on overlaps with autoimmune and mental disorders
Nudel, R., Allesøe, R. L., Thompson, W. K., Werge, Thomas, Rasmussen, Simon & Benros, Michael Eriksen, 2021, In: Journal of Translational Medicine. 19, 230.Research output: Contribution to journal › Journal article › Research › peer-review
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Pleiotropy between language impairment and broader behavioral disorders—an investigation of both common and rare genetic variants
Nudel, R., Appadurai, V., Buil, A., Nordentoft, Merete & Werge, Thomas, 2021, In: Journal of Neurodevelopmental Disorders. 13, 15 p., 54.Research output: Contribution to journal › Journal article › Research › peer-review
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CYP2D6 Genotyping and Antipsychotic-Associated Extrapyramidal Adverse Effects in a Randomized Trial of Aripiprazole Versus Quetiapine Extended Release in Children and Adolescents, Aged 12-17 Years, With First Episode Psychosis
Rudå, Ditte, mfw347, mfw347, Decara, M. S., Klauber, D. G., Fagerlund, Birgitte, Møllegaard, J. R., Linnet, Kristian, Werge, Thomas, Correll, C. U., Fink-Jensen, Anders, Jürgens, Gesche & Pagsberg, Anne Katrine, 2021, In: Journal of Clinical Psychopharmacology. 41, 6, p. 667-672Research output: Contribution to journal › Journal article › Research › peer-review
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Polygenic Heterogeneity Across Obsessive-Compulsive Disorder Subgroups Defined by a Comorbid Diagnosis
Strom, N. I., Grove, J., Meier, S. M., Bækvad-Hansen, M., Becker Nissen, J., Damm Als, T., Halvorsen, M., Nordentoft, Merete, Mortensen, P. B., Hougaard, D. M., Werge, Thomas, Mors, O., Børglum, A. D., Crowley, J. J., Bybjerg-Grauholm, J. & Mattheisen, M., 2021, In: Frontiers in Genetics. 12, 711624.Research output: Contribution to journal › Journal article › Research › peer-review
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Translating polygenic risk scores for clinical use by estimating the confidence bounds of risk prediction
Sun, J., Wang, Y., Folkersen, L., Borné, Y., Amlien, I., Buil, A., Orho-Melander, M., Børglum, A. D., Hougaard, D. M., Lotta, L. A., Jones, M., Baras, A., Melander, O., Engström, G., Werge, Thomas, Lage, K. & Regeneron Genetics Center, R. G. C., 2021, In: Nature Communications. 12, 5276.Research output: Contribution to journal › Journal article › Research › peer-review
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Association and genetic overlap between clinical chemistry tests and migraine
Tanha, H. M. & The International Headache Genetics Consortium (IHGC), T. I. H. G. C. (., 2021, In: Cephalalgia. 41, 11-12, p. 1208-1221 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Is the Association between Parents' Mental Illness and Child Psychopathology Mediated via Home Environment and Caregiver's Psychosocial Functioning? A Mediation Analysis of the Danish High Risk and Resilience Study-VIA7, a Population-Based Cohort Study
Uddin, M. J., Ekstrøm, C. T., Hemager, N., Christiani, C. A. J., Gregersen, M., Ellersgaard, D. V., Spang, K. S., Greve, A., Burton, B. K., Søndergaard, A., Nudel, R., Mortensen, P. B., Pedersen, M. G., Pedersen, C. B., Wang, Y., Werge, T., Bybjerg-Grauholm, J., Von Plessen, K. J., Bliksted, V., Mors, O. & 2 others, , 2021, In: Schizophrenia Bulletin Open. 2, 1, 12 p., sgab024.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 34394780
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Association of the leucine-7 to proline-7 variation in the signal sequence of neuropeptide Y with major depression
Research output: Contribution to journal › Journal article › Research › peer-review
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Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders
Research output: Contribution to journal › Journal article › Research › peer-review
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Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia
Research output: Contribution to journal › Journal article › Research › peer-review
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