A structural overview of the plasma membrane Na+,K+-ATPase and H+-ATPase ion pumps

Research output: Contribution to journalJournal articleResearchpeer-review

Jens Preben Morth, Bjørn Panella Pedersen, Morten Jeppe Buch-Pedersen, Jens Peter Andersen, Bente Vilsen, Michael Broberg Palmgren, Poul Nissen

Plasma membrane ATPases are primary active transporters of cations that maintain steep concentration gradients. The ion gradients and membrane potentials derived from them form the basis for a range of essential cellular processes, in particular Na(+)-dependent and proton-dependent secondary transport systems that are responsible for uptake and extrusion of metabolites and other ions. The ion gradients are also both directly and indirectly used to control pH homeostasis and to regulate cell volume. The plasma membrane H(+)-ATPase maintains a proton gradient in plants and fungi and the Na(+),K(+)-ATPase maintains a Na(+) and K(+) gradient in animal cells. Structural information provides insight into the function of these two distinct but related P-type pumps.
Original languageEnglish
JournalNature Reviews. Molecular Cell Biology
Issue number1
Pages (from-to)60-70
Number of pages11
Publication statusPublished - 2011

    Research areas

  • Animals, Cell Membrane, Humans, Proton-Translocating ATPases, Sodium-Potassium-Exchanging ATPase

ID: 44307609