Quantification of myocardial perfusion using cardiac magnetic resonance imaging correlates significantly to rubidium-82 positron emission tomography in patients with severe coronary artery disease: A preliminary study

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Abbas A Qayyum, Philip Hasbak, Henrik B W Larsson, Thomas E Christensen, Adam A Ghotbi, Anders B Mathiasen, Niels G Vejlstrup, Andreas Kjaer, Jens Kastrup

INTRODUCTION: Aim was to compare absolute myocardial perfusion using cardiac magnetic resonance imaging (CMRI) based on Tikhonov's procedure of deconvolution and rubidium-82 positron emission tomography (Rb-82 PET).

MATERIALS AND METHODS: Fourteen patients with coronary artery stenosis underwent rest and adenosine stress imaging by 1.5-Tesla MR Scanner and a mCT/PET 64-slice Scanner. CMRI were analyzed based on Tikhonov's procedure of deconvolution without specifying an explicit compartment model using our own software. PET images were analyzed using standard clinical software. CMRI and PET data was compared with Spearman's rho and Bland-Altman analysis.

RESULTS: CMRI results were strongly and significantly correlated with PET results for the absolute global myocardial perfusion differences (r=0.805, p=0.001) and for global myocardial perfusion reserve (MPR) (r=0.886, p<0.001). At vessel territorial level, CMRI results were also significantly correlated with absolute PET myocardial perfusion differences (r=0.737, p<0.001) and MPR (r=0.818, p<0.001). Each vessel territory had similar strong correlation for absolute myocardial perfusion differences (right coronary artery (RCA): r=0.787, p=0.001; left anterior descending artery (LAD): r=0.796, p=0.001; left circumflex artery (LCX): r=0.880, p<0.001) and for MPR (RCA: r=0.895, p<0.001; LAD: r=0.886, p<0.001; LCX: r=0.886, p<0.001).

CONCLUSION: On a global and vessel territorial basis, CMRI-measured absolute myocardial perfusion differences and MPR were strongly and significantly correlated with the Rb-82 PET findings.

Original languageEnglish
JournalEuropean Journal of Radiology
Issue number7
Pages (from-to)1120–1128
Number of pages9
Publication statusPublished - Jul 2014

    Research areas

  • Adult, Aged, Blood Flow Velocity, Coronary Artery Disease, Coronary Circulation, Female, Humans, Magnetic Resonance Angiography, Magnetic Resonance Imaging, Cine, Male, Middle Aged, Myocardial Perfusion Imaging, Positron-Emission Tomography, Radiopharmaceuticals, Reproducibility of Results, Rubidium Radioisotopes, Sensitivity and Specificity, Statistics as Topic

ID: 138383999