Antimicrobial activity of peptidomimetics against multidrug-resistant Escherichia coli: a comparative study of different backbones
Research output: Contribution to journal › Journal article › Research › peer-review
Rasmus D Jahnsen, Niels Frimodt-Møller, Henrik Franzyk
Novel remedies in the battle against multidrug-resistant bacterial strains are urgently needed, and one obvious approach involves antimicrobial peptides and mimics hereof. The impact of a- and ß-peptoid as well as ß(3)-amino acid modifications on the activity profile against ß-lactamase-producing Escherichia coli was assessed by testing an array comprising different types of cationic peptidomimetics obtained by a general monomer-based solid-phase synthesis protocol. Most of the peptidomimetics possessed high to moderate activity toward multidrug-resistant E. coli as opposed to the corresponding inactive peptides. Nevertheless, differences in hemolytic activities indicate that a careful choice of backbone design constitutes a significant parameter in the search for effective cationic antimicrobial peptidomimetics targeting specific bacteria.
|Journal||Journal of Medicinal Chemistry|
|Number of pages||9|
|Publication status||Published - 2012|