Weight loss and weight loss maintenance efficacy of a novel weight loss program: The retrospective RNPC® cohort

Research output: Contribution to journalJournal articleResearchpeer-review

Tanja Kongerslev Thorning, Odile Fabre, Rémy Legrand, Arne Astrup, Mads Fiil Hjorth

Objective: Bodyweight loss is essential to lower risk factors for type 2 diabetes and cardiovascular disease in overweight patients. Therefore, we examined the effectiveness of the RNPC® program for short and long term bodyweight reduction.
Methods: The RNPC® program is a novel weight loss and maintenance program achieving weight loss by an energy-restricted 800–1000 kcal/day high-protein low-glycemic diet (weight loss phase), followed by an intensive follow-up with a step-wise increase in energy intake to reach energy balance (weight stabilization
phases). The analysis included 12,179 overweight or obese patients treated in 54 RNPC® weight loss clinics in France.
Results: A total of 10,809 (89%) patients completed the initial weight loss phase and 2996 (25%) completed the full program. Median weight loss percentage was 10.7% (Interquartile range [IQR]: 5.8; 16.5) after a median of 105 days (IQR: 56; 175) during the weight loss phase, and a median of 17.5% (IQR: 12.7; 24.2) after a median of 251 days (IQR: 187; 350) at program completion.
Conclusion: The RNPC® program is cost-effective and well tolerated for short-term body weight loss as well as effective in the long term among the patients completing the program. The program might be particularly effective among patient with elevated fasting glucose.
Original languageEnglish
JournalObesity Medicine
Volume10
Pages (from-to)16-23
Number of pages8
ISSN2451-8476
DOIs
Publication statusPublished - 2018

ID: 196404293