Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians

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Søren K Rasmussen, Søren A Urhammer, Lars Erik Berglund, Jan N Jensen, Lars Hansen, Søren Morgenthaler Echwald, Knut Borch-Johnsen, Yukio Horikawa, Hirosato Mashima, Hans Lithell, Nancy J Cox, Torben Hansen, Graeme I Bell, Oluf Pedersen

Variations in the calpain-10 gene (CAPN10) have been identified among Mexican-Americans, and an at-risk haplotype combination (112/121) defined by three polymorphisms, UCSNP-43, -19, and -63, confers increased risk of type 2 diabetes. Here we examine the three polymorphisms in 1,594 Scandinavian subjects, including 409 type 2 diabetic patients, 200 glucose-tolerant control subjects, 322 young healthy subjects, 206 glucose-tolerant offspring of diabetic patients, and 457 glucose-tolerant 70-year-old men. The frequency of the 112/121 combination was not significantly different in 409 type 2 diabetic subjects compared with 200 glucose-tolerant control subjects (0.06 vs. 0.05; odds ratio 1.32 [95% CI 0.58-3.30]). In glucose-tolerant subjects, neither the single-nucleotide polymorphisms individually nor the 112/121 combination were associated with alterations in plasma glucose, serum insulin, or serum C-peptide levels at fasting or during an oral glucose tolerance test, estimates of insulin sensitivity, or glucose-induced insulin secretion. In conclusion, the frequency of the 112/121 at-risk haplotype of CAPN10 is low among Scandinavians and we were unable to demonstrate significant associations between the CAPN10 variants and type 2 diabetes, insulin resistance, or impaired insulin secretion.
Original languageEnglish
JournalDiabetes
Volume51
Issue number12
Pages (from-to)3561-7
Number of pages7
ISSN0012-1797
Publication statusPublished - 2002

    Research areas

  • Adult, Aged, Aged, 80 and over, Calpain, Chromosomes, Human, Pair 2, Cohort Studies, Control Groups, Diabetes Mellitus, Type 2, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Genetic Variation, Glucose, Haplotypes, Humans, Insulin, Insulin Resistance, Male, Middle Aged, Phenotype, Polymorphism, Genetic, Scandinavia

ID: 38457830