Urinary nucleic acid oxidation product levels show differential associations with pharmacological treatment in patients with type 2 diabetes

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Laura Kofoed Kjaer, Vanja Cejvanovic, Trine Henriksen, Torben Hansen, Oluf Pedersen, Cramer Kjeldahl Christensen, Christian Torp-Pedersen, Thomas Alexander Gerds, Ivan Brandslund, Thomas Mandrup-Poulsen, Henrik Enghusen Poulsen

The relationship between RNA and DNA oxidation and pharmacological treatment has not been systematically investigated in patients with type 2 diabetes (T2D). We aimed to investigate the association between pharmacological treatments and levels of urinary markers of nucleic acid oxidation in T2D patients. Vejle Diabetes Biobank cohort data was nested into nationwide registry data. Multiple logistic regression was used to associate drug usage with risk of high (above median) RNA and DNA oxidation. Data from 2664 T2D patients (64% male, age range: 25-75) were included. Questionnaire-validated lipid lowering drug use was associated with low RNA oxidation (Odds ratio, OR 0.71, 95% CI: [0.59-0.87]). Insulin and non-specific antidiabetic drugs were associated with low DNA oxidation (insulin: OR 0.60, 95% CI [0.49-0.73]). Oral antidiabetics were associated with high DNA oxidation and RNA oxidation (OR 1.30, 95% CI [1.10-1.53] and OR 1.26, 95% CI [1.07-1.29]). Our findings indicate that diabetes-related drugs are associated with RNA and DNA oxidation and further studies are required to determine causality in T2D patients.
Original languageEnglish
JournalFree Radical Research
Issue number6
Pages (from-to)694-703
Publication statusPublished - 3 Jun 2019

    Research areas

  • 8-Oxo-7, 8-dihydro-2-deoxyguanosine, 8-oxo-7, 8-dihydroguanosine, clinical pharmacology, oxidative stress, type 2 diabetes

ID: 226001469