Unexplained week-to-week variation in BNP and NT-proBNP is low in chronic heart failure patients during steady state.

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Morten Schou, Finn Gustafsson, Per H Nielsen, Lene H Madsen, Andreas Kjaer, Per R Hildebrandt

BACKGROUND: The usefulness of brain-natriuretic-peptide (BNP) and N-terminal-pro-brain-natriuretic-peptide (NT-proBNP) for monitoring of chronic heart failure (CHF) patients has been questioned because of high levels of unexplained variation. AIMS: Week-to-week total variance (CV(T)), unexplained variation (CV(I)), reference change values (RCV), index of individualities (IOI) and number of samples (N) with week-to-week intervals needed to estimate the underlying homeostatic set point (+/-15%) for BNP and NT-proBNP were calculated in pre-specified stable CHF patients. METHODS AND RESULTS: We measured plasma concentrations of BNP and NT-proBNP, clinical and laboratory variables in 20 CHF patients with a 7-days interval. Only patients considered to be in steady state were included. The CV(I) was 15% (BNP) and 8% (NT-proBNP). CV(T) was 16% (BNP) and 8% (NT-proBNP) and RCV was 43% (BNP) and 23% (NT-proBNP). IOI was 0.14 for BNP and 0.03 for NT-proBNP and N was 1 for BNP and 1 for NT-proBNP. CONCLUSIONS: Our data demonstrate that unexplained variation of BNP and NT-proBNP is low in CHF patients during steady state, which is a prerequisite for the use of these peptides for monitoring of the disease.
Original languageEnglish
JournalEuropean Journal of Heart Failure
Issue number1
Pages (from-to)68-74
Number of pages6
Publication statusPublished - 2006

Bibliographical note

Keywords: Aged; Aged, 80 and over; Algorithms; Biological Markers; Female; Heart Failure; Humans; Male; Middle Aged; Monitoring, Physiologic; Natriuretic Peptide, Brain; Patient Selection; Peptide Fragments; Reference Values; Reproducibility of Results; Ventricular Dysfunction, Left; Ventricular Function, Left

ID: 8465174