Type 3 ILCs in lung disease

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Amanda Ardain, James Zachary Porterfield, Henrik N. Kløverpris, Alasdair Leslie

The lungs represent a complex immune setting, balancing external environmental signals with a poised immune response that must protect from infection, mediate tissue repair, and maintain lung function. Innate lymphoid cells (ILCs) play a central role in tissue repair and homeostasis, and mediate protective immunity in a variety of mucosal tissues, including the lung. All three ILC subsets are present in the airways of both mice and humans; and ILC2s shown to have pivotal roles in asthma, airway hyper-responsiveness, and parasitic worm infection. The involvement of ILC3s in respiratory diseases is less well-defined, but they are known to be critical in homeostasis, infection and inflammation at other mucosal barriers, such as the gut. Moreover, they are important players in the IL17/IL22 axis, which is key to lung health. In this review, we discuss the emerging role of ILC3s in the context of infectious and inflammatory lung diseases, with a focus on data from human subjects.

Original languageEnglish
Article number92
JournalFrontiers in Immunology
Volume10
Issue numberJAN
ISSN1664-3224
DOIs
Publication statusPublished - 2019

    Research areas

  • Airway hypersensitivity, COPD, ILC3, Lung disease, Pnemonia, Pulmonary fibrosis, Tuberulosis

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