Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight

Research output: Contribution to journalJournal articleResearchpeer-review

E A Andersson, K Pilgaard, C Pisinger, M N Harder, N Grarup, K Faerch, P Poulsen, D R Witte, Torben Jørgensen, A Vaag, T Hansen, Oluf Pedersen

The fetal insulin hypothesis suggests that variation in the fetal genotype influencing insulin secretion or action may predispose to low birthweight and type 2 diabetes. We examined associations between 25 confirmed type 2 diabetes risk variants and birthweight in individuals from the Danish Inter99 population and in meta-analyses including Inter99 data and reported studies.
Original languageEnglish
JournalDiabetologia
Volume53
Issue number9
Pages (from-to)1908-16
Number of pages9
ISSN0012-186X
DOIs
Publication statusPublished - 1 Sep 2010

    Research areas

  • Adenylate Cyclase, Alleles, Birth Weight, Cyclin-Dependent Kinase 5, Diabetes Mellitus, Type 2, Female, Genome-Wide Association Study, Genotype, Homeodomain Proteins, Humans, Infant, Newborn, Pregnancy, Transcription Factors

ID: 33506369