T-wave morphology as a covariate in drug-induced QTc prolongation

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

Claus Graff, J. Matz, M. P. Andersen, J. K. Kanters, J. Nielsen, J. Q. Xue, E. Toft, J. J. Struijk

QT interval prolongation is one of the most common causes of delays and non-approvals in drug development due to the qualitative relationship between this interval and Torsade de Pointes (TdP) arrhythmia. However, not all drugs that prolong the QT interval to the same extent carry the same risk for TdP. Other indications, such as abnormal T-wave morphology, may play a role in differentiating between safe and unsafe drugs. We used moxifloxacin and d,l-sotalol to investigate whether concurrent changes for QTc and T-wave morphology could be used to describe the discrepancy in proarrhythmic risk between the two drugs. Our results provide evidence that these drugs have significantly different morphology-duration profiles at similar QTc prolongations. We propose to investigate whether concurrent assessment of QTc and T-wave morphology has general validity for drug safety evaluation.

Original languageEnglish
Title of host publicationComputers in Cardiology 2009, CinC 2009
Number of pages4
Volume36
Publication date1 Dec 2009
Pages589-592
Article number5445339
ISBN (Print)9781424472819
Publication statusPublished - 1 Dec 2009
Event36th Annual Conference of Computers in Cardiology, CinC 2009 - Park City, UT, United States
Duration: 13 Sep 200916 Sep 2009

Conference

Conference36th Annual Conference of Computers in Cardiology, CinC 2009
LandUnited States
ByPark City, UT
Periode13/09/200916/09/2009
SponsorEMB, IEEE, Medtronic, CareFusion, Biosense Webster

ID: 204299477