Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut

Research output: Contribution to journalJournal articleResearchpeer-review

By hydrophobic gel permeation and high pressure liquid chromatography we isolated from pig intestinal mucosa a peptide which corresponds to proglucagon 78-107 as suggested by chromatography and determination of its N-terminal sequence. Natural and synthetic proglucagon 78-107 dose dependently and potently increased insulin secretion from the isolated perfused pig pancreas. Proglucagon 78-107 also secreted by the small intestine may participate in the hormonal control of insulin secretion.
Original languageEnglish
JournalF E B S Letters
Issue number2
Pages (from-to)169-74
Number of pages6
Publication statusPublished - 1987

    Research areas

  • Animals, Glucagon, Ileum, Insulin, Intestinal Mucosa, Peptides, Swine

ID: 44293803