Transient cardiac dysfunction but elevated cardiac and kidney biomarkers 24 h following an ultra-distance running event in Mexican Tarahumara

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Transient cardiac dysfunction but elevated cardiac and kidney biomarkers 24 h following an ultra-distance running event in Mexican Tarahumara. / Christensen, Dirk L.; Espino, Diana; Infante-Ramirez, Rocio; Cervantes-Borunda, Monica S.; Hernandez-Torres, Rosa P.; Rivera-Cisneros, Antonio E.; Castillo, Daniel; Westgate, Kate; Terzic, Dijana; Brage, Søren; Hassager, Christian; Gøtze, Jens P.; Kjærgaard, Jesper.

In: Extreme Physiology & Medicine, Vol. 6, 3, 11.12.2017, p. 1-10.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Christensen, DL, Espino, D, Infante-Ramirez, R, Cervantes-Borunda, MS, Hernandez-Torres, RP, Rivera-Cisneros, AE, Castillo, D, Westgate, K, Terzic, D, Brage, S, Hassager, C, Gøtze, JP & Kjærgaard, J 2017, 'Transient cardiac dysfunction but elevated cardiac and kidney biomarkers 24 h following an ultra-distance running event in Mexican Tarahumara', Extreme Physiology & Medicine, vol. 6, 3, pp. 1-10. https://doi.org/10.1186/s13728-017-0057-5

APA

Christensen, D. L., Espino, D., Infante-Ramirez, R., Cervantes-Borunda, M. S., Hernandez-Torres, R. P., Rivera-Cisneros, A. E., ... Kjærgaard, J. (2017). Transient cardiac dysfunction but elevated cardiac and kidney biomarkers 24 h following an ultra-distance running event in Mexican Tarahumara. Extreme Physiology & Medicine, 6, 1-10. [3]. https://doi.org/10.1186/s13728-017-0057-5

Vancouver

Christensen DL, Espino D, Infante-Ramirez R, Cervantes-Borunda MS, Hernandez-Torres RP, Rivera-Cisneros AE et al. Transient cardiac dysfunction but elevated cardiac and kidney biomarkers 24 h following an ultra-distance running event in Mexican Tarahumara. Extreme Physiology & Medicine. 2017 Dec 11;6:1-10. 3. https://doi.org/10.1186/s13728-017-0057-5

Author

Christensen, Dirk L. ; Espino, Diana ; Infante-Ramirez, Rocio ; Cervantes-Borunda, Monica S. ; Hernandez-Torres, Rosa P. ; Rivera-Cisneros, Antonio E. ; Castillo, Daniel ; Westgate, Kate ; Terzic, Dijana ; Brage, Søren ; Hassager, Christian ; Gøtze, Jens P. ; Kjærgaard, Jesper. / Transient cardiac dysfunction but elevated cardiac and kidney biomarkers 24 h following an ultra-distance running event in Mexican Tarahumara. In: Extreme Physiology & Medicine. 2017 ; Vol. 6. pp. 1-10.

Bibtex

@article{9e44dcb618fe4330a7203e0698f91bc0,
title = "Transient cardiac dysfunction but elevated cardiac and kidney biomarkers 24 h following an ultra-distance running event in Mexican Tarahumara",
abstract = "Background: The Mexican Tarahumara are accustomed to running ultra-distance races. No data exist on the acute physiological changes following ultra-distance running and physiological-biomarker associations in this population. Thus, we aimed to investigate the acute impact (≤ 24 h) on functional and biochemical changes of the cardiac muscle and biochemical changes associated with kidney function following a 63-km ultra-distance race with an altitude difference of 1800 m in Mexican Tarahumara athletes.Methods: Ten Tarahumara male athletes (mean ± SD age = 29.9 ± 6.6 years) volunteered to participate in the study. VO2max was assessed by a sub-maximal step test individually calibrated combining heart rate and accelerometry. Standard transthoracic echocardiography methodology and venipuncture blood tests were carried out at four time points: pre-race, immediately post-race, 6 h, and 24 h post-race.Results: Estimated mean VO2max was 54.5 (± 8.8) mL O2 min−1 kg−1 and average physiological activity intensity was 746 (± 143) J min−1 kg −1 (~ 11.5 METs). When compared to pre-race values, significant changes in left ventricular ejection fraction (LVEF) and LV end-diastolic volume (− 15{\%}, p < 0.001 for both parameters), cardiac output (39{\%}, p < 0.001), and maximal longitudinal velocity (− 13{\%}, p < 0.009) were seen post-race with LVEF also being decreased at < 6 h post-race (− 8{\%}, p < 0.014). Plasma biomarkers mid-regional pro-atrial natriuretic peptide, copeptin-ultra sensitive, and high-sensitivity cardiac troponin T remained significantly elevated at 24 h post-race, and the two latter were inversely associated with LVEF (p < 0.04). Kidney dysfunction was indicated by increased post-race copeptin-ultra sensitive.Conclusions: The athletes participating in this study had acute transient cardiac dysfunction as assessed by echocardiography but elevated cardiac and kidney biomarkers at 24 h following a 63-km race with extreme altitude variation.",
keywords = "Echocardiography, Cardiac biomarkers, Kidney biomarkers, Ultra-marathon, Tarahumara",
author = "Christensen, {Dirk L.} and Diana Espino and Rocio Infante-Ramirez and Cervantes-Borunda, {Monica S.} and Hernandez-Torres, {Rosa P.} and Rivera-Cisneros, {Antonio E.} and Daniel Castillo and Kate Westgate and Dijana Terzic and S{\o}ren Brage and Christian Hassager and G{\o}tze, {Jens P.} and Jesper Kj{\ae}rgaard",
year = "2017",
month = "12",
day = "11",
doi = "10.1186/s13728-017-0057-5",
language = "English",
volume = "6",
pages = "1--10",
journal = "Extreme Physiology & Medicine",
issn = "2046-7648",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Transient cardiac dysfunction but elevated cardiac and kidney biomarkers 24 h following an ultra-distance running event in Mexican Tarahumara

AU - Christensen, Dirk L.

AU - Espino, Diana

AU - Infante-Ramirez, Rocio

AU - Cervantes-Borunda, Monica S.

AU - Hernandez-Torres, Rosa P.

AU - Rivera-Cisneros, Antonio E.

AU - Castillo, Daniel

AU - Westgate, Kate

AU - Terzic, Dijana

AU - Brage, Søren

AU - Hassager, Christian

AU - Gøtze, Jens P.

AU - Kjærgaard, Jesper

PY - 2017/12/11

Y1 - 2017/12/11

N2 - Background: The Mexican Tarahumara are accustomed to running ultra-distance races. No data exist on the acute physiological changes following ultra-distance running and physiological-biomarker associations in this population. Thus, we aimed to investigate the acute impact (≤ 24 h) on functional and biochemical changes of the cardiac muscle and biochemical changes associated with kidney function following a 63-km ultra-distance race with an altitude difference of 1800 m in Mexican Tarahumara athletes.Methods: Ten Tarahumara male athletes (mean ± SD age = 29.9 ± 6.6 years) volunteered to participate in the study. VO2max was assessed by a sub-maximal step test individually calibrated combining heart rate and accelerometry. Standard transthoracic echocardiography methodology and venipuncture blood tests were carried out at four time points: pre-race, immediately post-race, 6 h, and 24 h post-race.Results: Estimated mean VO2max was 54.5 (± 8.8) mL O2 min−1 kg−1 and average physiological activity intensity was 746 (± 143) J min−1 kg −1 (~ 11.5 METs). When compared to pre-race values, significant changes in left ventricular ejection fraction (LVEF) and LV end-diastolic volume (− 15%, p < 0.001 for both parameters), cardiac output (39%, p < 0.001), and maximal longitudinal velocity (− 13%, p < 0.009) were seen post-race with LVEF also being decreased at < 6 h post-race (− 8%, p < 0.014). Plasma biomarkers mid-regional pro-atrial natriuretic peptide, copeptin-ultra sensitive, and high-sensitivity cardiac troponin T remained significantly elevated at 24 h post-race, and the two latter were inversely associated with LVEF (p < 0.04). Kidney dysfunction was indicated by increased post-race copeptin-ultra sensitive.Conclusions: The athletes participating in this study had acute transient cardiac dysfunction as assessed by echocardiography but elevated cardiac and kidney biomarkers at 24 h following a 63-km race with extreme altitude variation.

AB - Background: The Mexican Tarahumara are accustomed to running ultra-distance races. No data exist on the acute physiological changes following ultra-distance running and physiological-biomarker associations in this population. Thus, we aimed to investigate the acute impact (≤ 24 h) on functional and biochemical changes of the cardiac muscle and biochemical changes associated with kidney function following a 63-km ultra-distance race with an altitude difference of 1800 m in Mexican Tarahumara athletes.Methods: Ten Tarahumara male athletes (mean ± SD age = 29.9 ± 6.6 years) volunteered to participate in the study. VO2max was assessed by a sub-maximal step test individually calibrated combining heart rate and accelerometry. Standard transthoracic echocardiography methodology and venipuncture blood tests were carried out at four time points: pre-race, immediately post-race, 6 h, and 24 h post-race.Results: Estimated mean VO2max was 54.5 (± 8.8) mL O2 min−1 kg−1 and average physiological activity intensity was 746 (± 143) J min−1 kg −1 (~ 11.5 METs). When compared to pre-race values, significant changes in left ventricular ejection fraction (LVEF) and LV end-diastolic volume (− 15%, p < 0.001 for both parameters), cardiac output (39%, p < 0.001), and maximal longitudinal velocity (− 13%, p < 0.009) were seen post-race with LVEF also being decreased at < 6 h post-race (− 8%, p < 0.014). Plasma biomarkers mid-regional pro-atrial natriuretic peptide, copeptin-ultra sensitive, and high-sensitivity cardiac troponin T remained significantly elevated at 24 h post-race, and the two latter were inversely associated with LVEF (p < 0.04). Kidney dysfunction was indicated by increased post-race copeptin-ultra sensitive.Conclusions: The athletes participating in this study had acute transient cardiac dysfunction as assessed by echocardiography but elevated cardiac and kidney biomarkers at 24 h following a 63-km race with extreme altitude variation.

KW - Echocardiography

KW - Cardiac biomarkers

KW - Kidney biomarkers

KW - Ultra-marathon

KW - Tarahumara

U2 - 10.1186/s13728-017-0057-5

DO - 10.1186/s13728-017-0057-5

M3 - Journal article

VL - 6

SP - 1

EP - 10

JO - Extreme Physiology & Medicine

JF - Extreme Physiology & Medicine

SN - 2046-7648

M1 - 3

ER -

ID: 188452360