The SH2D2A gene and susceptibility to multiple sclerosis

Research output: Contribution to journalJournal articleResearchpeer-review

A.R. Lorentzen, C. Smestad, B.A. Lie, Annette Bang Oturai, E. Akesson, J. Saarela, K.M. Myhr, F. Vartdal, E.G. Celius, Per Soelberg Sørensen, J. Hillert, A. Spurkland, H.F. Harbo

We previously reported an association between the SH2D2A gene encoding TSAd and multiple sclerosis (MS). Here a total of 2128 Nordic MS patients and 2004 controls were genotyped for the SH2D2A promoter GA repeat polymorphism and rs926103 encoding a serine to asparagine substitution at amino acid position 52 in TSAd. The GA(16)-rs926103()A haplotype was associated with MS in Norwegians (OR 1.4, P=0.04). A similar trend was observed among Danes. In the independent Norwegian, Danish and Swedish sample sets the GA(16) allele showed a combined OR of 1.13, P=0.05. Thus, the present study shows that the SH2D2A gene may contribute to susceptibility to MS
Udgivelsesdato: 2008/7/15
Original languageEnglish
JournalJournal of Neuroimmunology
Volume197
Issue number2
Pages (from-to)152-158
Number of pages6
ISSN0165-5728
Publication statusPublished - 2008

ID: 10924678