The L-alpha-amino acid receptor GPRC6A is expressed in the islets of Langerhans but is not involved in L-arginine-induced insulin release

Research output: Contribution to journalJournal articleResearchpeer-review

Sanela Smajilovic, Christoffer Clemmensen, Lars Dan Johansen, Petrine Wellendorph, Jens Juul Holst, Peter Grevsen Thams, Egbuna Ogo, Hans Bräuner-Osborne

GPRC6A is a seven-transmembrane receptor activated by a wide range of L: -a-amino acids, most potently by L: -arginine and other basic amino acids. The receptor is broadly expressed, but its exact physiological role remains to be elucidated. It is well established that L: -arginine stimulates insulin secretion; therefore, the receptor has been hypothesized to have a role in regulating glucose metabolism. In this study, we demonstrate that GPRC6A is expressed in islets of Langerhans, but activation of the receptor by L-arginine did not stimulate insulin secretion. We also investigated central metabolic parameters in GPRC6A knockout mice compared with wildtype littermates and found no difference in glucose metabolism or body fat percentage when mice were administered a standard chow diet. In conclusion, our data do not support a role for GPRC6A in L-arginine-induced insulin release and glucose metabolism under normal physiological conditions.
Original languageEnglish
JournalAmino Acids
Volume44
Issue number2
Pages (from-to)383-390
Number of pages8
ISSN0939-4451
DOIs
Publication statusPublished - 2013

Bibliographical note

Keywords: GPRC6A, L-Arginine, Insulin release

ID: 38321500