The gut microbiota influence behavior in the subchronic PCP induced animal model of schizophrenia

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Documents

Bettina Merete Pyndt Jørgensen, Paul Redrobe, Tina Brønnum Pedersen, Ellika Marie Selfjord, Dennis Sandris Nielsen, Niels Plath, Axel Kornerup Hansen, Dorte Bratbo Sørensen

The gut microbiota has major impact on the individual. Here we show that the gut microbiota influence behavior in the subchronic PCP induced animal model of schizophrenia. The gut microbiota were changed in the group treated subchronic with PCP, and restoration coincided with normalisation of memory performance in lister hooded rats. Furthermore the individual gut microbiota correlated to the individual behavior abserved in the tests conducted. In conclusion results show an influence of the gut microbiota on behavior in this model, and therefore it might be relavant to include the information from the gut in analyses of studies using this model in the future.
Original languageEnglish
Publication date2013
Publication statusPublished - 2013
EventNeurodag 2013: Neurobiology in action - University of Copenhagen, Banquet Hall, Copenhagen, Denmark
Duration: 25 Oct 201325 Oct 2013

Seminar

SeminarNeurodag 2013
LocationUniversity of Copenhagen, Banquet Hall
CountryDenmark
CityCopenhagen
Period25/10/201325/10/2013

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