The G protein-coupled receptor subset of the dog genome is more similar to that in humans than rodents

Research output: Contribution to journalJournal articleResearchpeer-review

Tatjana Haitina, Robert Fredriksson, Steven M Foord, Helgi B Schiöth, David E. Gloriam

The dog is an important model organism and it is considered to be closer to humans than rodents regarding metabolism and responses to drugs. The close relationship between humans and dogs over many centuries has lead to the diversity of the canine species, important genetic discoveries and an appreciation of the effects of old age in another species. The superfamily of G protein-coupled receptors (GPCRs) is one of the largest gene families in most mammals and the most exploited in terms of drug discovery. An accurate comparison of the GPCR repertoires in dog and human is valuable for the prediction of functional similarities and differences between the species.
Original languageEnglish
JournalB M C Genomics
Pages (from-to)24
Publication statusPublished - 2009
Externally publishedYes

ID: 45811445