The effect of FOXA2 rs1209523 on glucose-related phenotypes and risk of type 2 diabetes in Danish individuals

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Karina Banasik, Mette Hollensted, Ehm Andersson, Thomas Sparsø, Annelli Sandbaek, Torsten Lauritzen, Torben Jørgensen, Daniel R Witte, Oluf Pedersen, Torben Hansen

Variations within the FOXA family have been studied for a putative contribution to the risk of type 2 diabetes (T2D), and recently the minor T-allele of FOXA2 rs1209523 was reported to associate with decreased fasting plasma glucose levels in a study using a weighted false discovery rate control procedure to enhance the statistical power of genome wide association studies in detecting associations between low-frequency variants and a given trait.Thus, the primary aim of this study was to investigate whether the minor T-allele of rs1205923 in FOXA2 associated with 1) decreased fasting plasma glucose and 2) a lower risk of developing T2D. Secondly, we investigated whether rs1205923 in FOXA2 associated with other glucose-related phenotypes.
Original languageEnglish
JournalB M C Medical Genetics
Pages (from-to)10
Publication statusPublished - 2012

ID: 38334903