The association of IgA deficiency on infection rate, self-perceived health, and levels of C-reactive protein in healthy blood donors

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Sabina Chaudhary Hauge, Charlotte Kæstel Jensen, Leif Kofoed Nielsen, Ole B. Pedersen, Erik Sørensen, Lise Wegner Thørner, Henrik Hjalgrim, Christian Erikstrup, Kaspar René Nielsen, Kathrine Agergård Kaspersen, Maria Didriksen, Morten Dziegiel, Henrik Ullum

The clinical importance of immunoglobulin A (IgA) deficiency in otherwise healthy individuals is not well described. We aimed to investigate the self-reported mental and physical health and the risk of infection in IgA-deficient blood donors compared to healthy control blood donors. Infectious events, recorded in public health registries either as prescriptions filled of any antimicrobial medicine or as hospital infections, were compared between 177 IgA-deficient blood donors and 1770 control blood donors. A subset of the IgA-deficient donors were further characterized by self-reported health (Short Form-12, n = 28) and circulating C-reactive protein (CRP) (n = 10). IgA-deficient individuals had lower self-reported mental health (p = 0.01) and higher CRP (p < 0.05). A strong trend was found regarding prescription of antimicrobial medicine (hazard ratio = 1.19, p = 0.05). No association was found with hospital infections (hazard ratio = 1.02, p = 0.95) or self-reported physical health (p = 0.86). IgA-deficient blood donors have impaired self-reported mental health, enhanced inflammation and possibly an increased risk of infection. Despite these findings, this study does not provide sufficient evidence to warrant specific health precautions for donors with IgA deficiency.

Original languageEnglish
JournalA P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
Volume126
Issue number3
Pages (from-to)248-256
Number of pages9
ISSN0903-4641
DOIs
Publication statusPublished - 1 Mar 2018

    Research areas

  • Blood donors, C-reactive protein, IgA deficiency, infection, quality of life

ID: 198566028