Target intervention against multiple-risk markers to reduce cardiovascular disease in patients with type 2 diabetes

Research output: Contribution to journalJournal articleResearchpeer-review

Peter Gaede, Oluf Pedersen

The risk of cardiovascular disease is markedly increased in patients with type 2 diabetes with a prevalence twice as high compared to the background population. With the recognition of multiple concomitant risk factors for both microvascular as well as cardiovascular disease in type 2 diabetic patients, treatment strategies have changed during recent years. This review focuses on the many recent drug trials that have set the course for an effective multifactorial treatment of the disease. Thus, the Steno-2 Study has shown that an intensified multifactorial intervention targeting several risk factors for cardiovascular disease is capable of reducing the risk for a combined endpoint of cardiovascular mortality, non-fatal myocardial infarction, non-fatal stroke, coronary interventions, revascularisation to legs, and amputations by 50%.
Original languageEnglish
JournalAnnals of Medicine
Volume36
Issue number5
Pages (from-to)355-66
Number of pages12
ISSN0785-3890
Publication statusPublished - 2004

    Research areas

  • Albuminuria, Angiotensin-Converting Enzyme Inhibitors, Cardiovascular Diseases, Clinical Trials as Topic, Diabetes Mellitus, Type 2, Exercise, Humans, Hyperglycemia, Hyperlipidemias, Hypertension, Risk Factors, Smoking Cessation

ID: 38457160