Studies of variability in the PTEN gene among Danish caucasian patients with Type II diabetes mellitus

Research output: Contribution to journalJournal articleResearchpeer-review

L Hansen, J N Jensen, C T Ekstrøm, H Vestergaard, T Hansen, O Pedersen, Henrik Vestergaard

Phosphatase and tensin homologue deleted from chromosome ten (PTEN) has recently been characterized as a novel member in the expanding network of proteins regulating the intracellular effects of insulin. By dephosphorylation of phosphatidyl-inositol-(3, 4, 5)-trisphosphate (PIP3) the PTEN protein regulates the insulin-dependent phosphoinositide 3-kinase (PI3K) signalling cassette and accordingly might function as a regulator of insulin sensitivity in skeletal muscle and adipose tissue. In this study we tested PTEN as a candidate gene for insulin resistance and late-onset Type II (non-insulin-dependent) diabetes mellitus in a Danish Caucasian population.
Original languageEnglish
JournalDiabetologia
Volume44
Issue number2
Pages (from-to)237-240
Number of pages4
ISSN0012-186X
DOIs
Publication statusPublished - Feb 2001

    Research areas

  • Adipose Tissue, Adult, Aged, Blood Glucose, Blood Pressure, C-Peptide, Denmark, Diabetes Mellitus, Type 2, European Continental Ancestry Group, Exons, Fasting, Gene Frequency, Humans, Insulin, Insulin Resistance, Middle Aged, Muscle, Skeletal, PTEN Phosphohydrolase, Phosphatidylinositol 3-Kinases, Phosphatidylinositol Phosphates, Phosphoric Monoester Hydrolases, Polymerase Chain Reaction, Polymorphism, Genetic, Polymorphism, Restriction Fragment Length, Polymorphism, Single-Stranded Conformational, Tumor Suppressor Proteins

ID: 96264