Studies of the common DIO2 Thr92Ala polymorphism and metabolic phenotypes in 7342 Danish white subjects

Research output: Contribution to journalJournal articleResearchpeer-review

Niels Grarup, Mette K Andersen, Camilla H Andreasen, Anders Albrechtsen, Knut Borch-Johnsen, Torben Jørgensen, Johan Auwerx, Ole Schmitz, Torben Hansen, Oluf Pedersen

The type 2 iodothyronine deiodinase (D2) catalyzes the conversion of T(4) to the active form of thyroid hormone, which is a critical regulator of thermogenesis and glucose metabolism. A Thr92Ala polymorphism in the gene encoding D2 (DIO2) has been reported to associate with insulin resistance.
Original languageEnglish
JournalJournal of Clinical Endocrinology and Metabolism
Volume92
Issue number1
Pages (from-to)363-6
Number of pages4
ISSN0021-972X
DOIs
Publication statusPublished - 2007

    Research areas

  • Adult, Cohort Studies, Diabetes Mellitus, Type 2, European Continental Ancestry Group, Female, Humans, Insulin Resistance, Iodide Peroxidase, Male, Middle Aged, Obesity, Phenotype, Polymorphism, Genetic

ID: 38336359