Studies of the association of the GNB3 825C>T polymorphism with components of the metabolic syndrome in white Danes

Research output: Contribution to journalJournal articleResearchpeer-review

G Andersen, J Overgaard, Anders Albrechtsen, C Glümer, K Borch-Johnsen, T Jørgensen, T Hansen, O Pedersen

The 825C>T polymorphism in the gene encoding the G protein beta3 subunit (GNB3) causes enhanced G protein activation and increased in vitro cell proliferation. This polymorphism is also repeatedly associated with an increased risk of hypertension and has been studied in relation to obesity with divergent results. Only a few association studies have investigated whether this polymorphism is related to type 2 diabetes or the metabolic syndrome. We estimated the impact of the GNB3 825C>T polymorphism in relatively large-scale association studies of common phenotypes of the metabolic syndrome.
Original languageEnglish
JournalDiabetologia
Volume49
Issue number1
Pages (from-to)75-82
Number of pages8
ISSN0012-186X
DOIs
Publication statusPublished - Jan 2006

    Research areas

  • Adult, Blood Glucose, Denmark, European Continental Ancestry Group, Fasting, Female, Genotype, Glucose Tolerance Test, Heterotrimeric GTP-Binding Proteins, Humans, Hypertension, Male, Metabolic Syndrome X, Middle Aged, Polymorphism, Single Nucleotide, Risk Factors

ID: 45578331