Studies of the Association of Arg72Pro of Tumor Suppressor Protein p53 with Type 2 Diabetes in a Combined Analysis of 55,521 Europeans
Research output: Contribution to journal › Journal article › Research › peer-review
Kristoffer Sølvsten Burgdorf, Niels Grarup, Johanne Marie Justesen, Marie Neergaard Harder, Daniel Rinse Witte, Torben Jørgensen, Annelli Sandbæk, Torsten Lauritzen, Sten Madsbad, Torben Hansen, DIAGRAM Consortium, Oluf Pedersen
SLC2A2, SLC2A4 and FOXC2 with type 2 diabetes in 4,805 Finnish individuals. We aimed to replicate these associations in a
Danish case-control study and to substantiate any replicated associations in meta-analyses. Furthermore, we evaluated the
impact on diabetes-related intermediate traits in a population-based sample of middle-aged Danes.
Methods: We genotyped nine lead variants in the seven genes in 4,973 glucose-tolerant and 3,612 type 2 diabetes Danish
individuals. In meta-analyses we combined case-control data from the DIAGRAM+ Consortium (n = 47,117) and the present
genotyping results. The quantitative trait studies involved 5,882 treatment-naive individuals from the Danish Inter99 study.
Results: None of the nine investigated variants were significantly associated with type 2 diabetes in the Danish samples.
However, for all nine variants the estimate of increase in type 2 diabetes risk was observed for the same allele as previously
reported. In a meta-analysis of published and online data including 55,521 Europeans the G-allele of rs1042522 in TP53
showed significant association with type 2 diabetes (OR = 1.06 95% CI 1.02–1.11, p = 0.0032). No substantial associations
with diabetes-related intermediary phenotypes were found.
Conclusion: The G-allele of TP53 rs1042522 is associated with an increased prevalence of type 2 diabetes in a combined
analysis of 55,521 Europeans.
|Journal||P L o S One|
|Number of pages||6|
|Publication status||Published - 2011|
- Case-Control Studies, Diabetes Mellitus, Type 2, Europe, European Continental Ancestry Group, Genome-Wide Association Study, Genotype, Humans, Tumor Suppressor Protein p53