Studies of the Ala/Val98 polymorphism of the hepatocyte nuclear factor-1alpha gene and the relationship to beta-cell function during an OGTT in glucose-tolerant women with and without previous gestational diabetes mellitus
Research output: Contribution to journal › Journal article › Research › peer-review
In pregnancies complicated by gestational diabetes mellitus (GDM) an increased demand for insulin is not met due to beta-cell dysfunction. An Ala/Val polymorphism at codon 98 of the hepatocyte nuclear factor-1alpha (HNF-1alpha) gene has been associated with decreased serum insulin and C-peptide responses during an oral glucose tolerance test (OGTT) in glucose-tolerant subjects. The aims of the present study were to evaluate the influence of the polymorphism on the serum insulin and C-peptide responses to an OGTT in glucose-tolerant women with and without previous GDM and to investigate if this polymorphism is associated with GDM.
|Number of pages||6|
|Publication status||Published - Dec 2004|
- Adult, C-Peptide, Case-Control Studies, DNA-Binding Proteins, Diabetes, Gestational, Female, Glucose Tolerance Test, Hepatocyte Nuclear Factor 1, Hepatocyte Nuclear Factor 1-alpha, Humans, Insulin, Islets of Langerhans, Nuclear Proteins, Polymorphism, Genetic, Pregnancy, Statistics, Nonparametric, Transcription Factors