Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies

Research output: Contribution to journalJournal articleResearchpeer-review

Niels Grarup, Chrisian S Rose, Ehm A Andersson, Gitte Andersen, Arne L Nielsen, Anders Albrechtsen, Jesper O Clausen, Signe S Rasmussen, Torben Jørgensen, Annelli Sandbaek, Torsten Lauritzen, Ole Schmitz, Torben Hansen, Oluf Pedersen

In the present study, we aimed to validate the type 2 diabetes susceptibility alleles identified in six recent genome-wide association studies in the HHEX/KIF11/IDE (rs1111875), CDKN2A/B (rs10811661), and IGF2BP2 (rs4402960) loci, as well as the intergenic rs9300039 variant. Furthermore, we aimed to characterize quantitative metabolic risk phenotypes of the four variants.
Original languageEnglish
JournalDiabetes
Volume56
Issue number12
Pages (from-to)3105-11
Number of pages7
ISSN0046-0192
DOIs
Publication statusPublished - 2007

    Research areas

  • Adult, Cohort Studies, Cyclin-Dependent Kinase Inhibitor p15, Cyclin-Dependent Kinase Inhibitor p16, Denmark, Diabetes Mellitus, Type 2, European Continental Ancestry Group, Genetic Predisposition to Disease, Genetic Variation, Genome, Human, Glucose Intolerance, Homeodomain Proteins, Humans, Insulin, Insulin-Like Growth Factor Binding Protein 2, Introns, Middle Aged, Reference Values, Reproducibility of Results, Transcription Factors

ID: 38335610