Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies

Research output: Contribution to journalJournal articleResearchpeer-review

Niels Grarup, Chrisian S Rose, Ehm A Andersson, Gitte Andersen, Arne L Nielsen, Anders Albrechtsen, Jesper O Clausen, Signe S Rasmussen, Torben Jørgensen, Annelli Sandbaek, Torsten Lauritzen, Ole Schmitz, Torben Hansen, Oluf Pedersen

In the present study, we aimed to validate the type 2 diabetes susceptibility alleles identified in six recent genome-wide association studies in the HHEX/KIF11/IDE (rs1111875), CDKN2A/B (rs10811661), and IGF2BP2 (rs4402960) loci, as well as the intergenic rs9300039 variant. Furthermore, we aimed to characterize quantitative metabolic risk phenotypes of the four variants.
Original languageEnglish
Issue number12
Pages (from-to)3105-11
Number of pages7
Publication statusPublished - 2007

    Research areas

  • Adult, Cohort Studies, Cyclin-Dependent Kinase Inhibitor p15, Cyclin-Dependent Kinase Inhibitor p16, Denmark, Diabetes Mellitus, Type 2, European Continental Ancestry Group, Genetic Predisposition to Disease, Genetic Variation, Genome, Human, Glucose Intolerance, Homeodomain Proteins, Humans, Insulin, Insulin-Like Growth Factor Binding Protein 2, Introns, Middle Aged, Reference Values, Reproducibility of Results, Transcription Factors

ID: 38335610