Studies of association of AGPAT6 variants with type 2 diabetes and related metabolic phenotypes in 12,068 Danes

Research output: Contribution to journalJournal articleResearchpeer-review

Lena Sønder Snogdal, Niels Grarup, Karina Banasik, Mette Wod, Torben Jørgensen, Daniel R Witte, Torsten Lauritzen, Aneta Aleksandra Nielsen, Ivan Brandslund, Cramer Christensen, Oluf Pedersen, Knud Bonnet Yderstræde, Henning Beck-Nielsen, Jan Erik Henriksen, Torben Hansen, Kurt Højlund

Type 2 diabetes, obesity and insulin resistance are characterized by hypertriglyceridemia and ectopic accumulation of lipids in liver and skeletal muscle. AGPAT6 encodes a novel glycerol-3 phosphate acyltransferase, GPAT4, which catalyzes the first step in the de novo triglyceride synthesis. AGPAT6-deficient mice show lower weight and resistance to diet- and genetically induced obesity. Here, we examined whether common or low-frequency variants in AGPAT6 associate with type 2 diabetes or related metabolic traits in a Danish population.
Original languageEnglish
JournalBMC Medical Genetics
Volume14
Issue number1
Pages (from-to)113
ISSN1471-2350
DOIs
Publication statusPublished - 25 Oct 2013

ID: 66819335