Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes

Research output: Contribution to journalJournal articleResearchpeer-review

Kristoffer Sølvsten Burgdorf, Camilla Helene Sandholt, Thomas Sparsø, Gitte Andersen, Daniel R Witte, Torben Jørgensen, Anelli Sandbaek, Torsten Lauritzen, Thorkild I A Sørensen, Sten Madsbad, Torben Hansen, Oluf Pedersen

Lipin-1, encoded by LPIN1, is expressed in the major metabolically active tissues. Decreased expression of lipin-1 in adipose tissue correlates with increased insulin resistance, and tagging of the LPIN1 locus has shown that rs33997857, rs6744682, and rs6708316 associate with metabolic phenotypes, specifically body mass index (BMI) and fasting serum lipid levels, both on the individual single-nucleotide polymorphism level and with a three-marker haplotype. Our aim was to validate the reported findings in the Danish population.
Original languageEnglish
JournalEuropean Journal of Endocrinology
Volume163
Issue number1
Pages (from-to)81-7
Number of pages7
ISSN0804-4643
DOIs
Publication statusPublished - 1 Jul 2010

    Research areas

  • Adult, Body Mass Index, Case-Control Studies, Denmark, Diabetes Mellitus, Type 2, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Genetic Variation, Genotype, Haplotypes, Humans, Male, Middle Aged, Nuclear Proteins, Obesity, Waist Circumference

ID: 33502175