Starting lithium prophylaxis early v. late in bipolar disorder

Research output: Contribution to journalJournal articleResearchpeer-review

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Starting lithium prophylaxis early v. late in bipolar disorder. / Kessing, Lars Vedel; Vradi, Eleni; Andersen, Per Kragh.

In: The British journal of psychiatry : the journal of mental science, Vol. 205, No. 3, 09.2014, p. 214-20.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Kessing, LV, Vradi, E & Andersen, PK 2014, 'Starting lithium prophylaxis early v. late in bipolar disorder', The British journal of psychiatry : the journal of mental science, vol. 205, no. 3, pp. 214-20. https://doi.org/10.1192/bjp.bp.113.142802

APA

Kessing, L. V., Vradi, E., & Andersen, P. K. (2014). Starting lithium prophylaxis early v. late in bipolar disorder. The British journal of psychiatry : the journal of mental science, 205(3), 214-20. https://doi.org/10.1192/bjp.bp.113.142802

Vancouver

Kessing LV, Vradi E, Andersen PK. Starting lithium prophylaxis early v. late in bipolar disorder. The British journal of psychiatry : the journal of mental science. 2014 Sep;205(3):214-20. https://doi.org/10.1192/bjp.bp.113.142802

Author

Kessing, Lars Vedel ; Vradi, Eleni ; Andersen, Per Kragh. / Starting lithium prophylaxis early v. late in bipolar disorder. In: The British journal of psychiatry : the journal of mental science. 2014 ; Vol. 205, No. 3. pp. 214-20.

Bibtex

@article{b0da999a0d61460498729f3ba2e1606f,
title = "Starting lithium prophylaxis early v. late in bipolar disorder",
abstract = "BACKGROUND: No study has investigated when preventive treatment with lithium should be initiated in bipolar disorder.AIMS: To compare response rates among patients with bipolar disorder starting treatment with lithium early v. late.METHOD: Nationwide registers were used to identify all patients with a diagnosis of bipolar disorder in psychiatric hospital settings who were prescribed lithium during the period 1995-2012 in Denmark (n = 4714). Lithium responders were defined as patients who, following a stabilisation lithium start-up period of 6 months, continued lithium monotherapy without being admitted to hospital. Early v. late intervention was defined in two ways: (a) start of lithium following first contact; and (b) start of lithium following a diagnosis of a single manic/mixed episode.RESULTS: Regardless of the definition used, patients who started lithium early had significantly decreased rates of non-response to lithium compared with the rate for patients starting lithium later (adjusted analyses: first v. later contact: P<0.0001; hazard ratio (HR) = 0.87, 95{\%} CI 0.76-0.91; single manic/mixed episode v. bipolar disorder: P<0.0001; HR = 0.75, 95{\%} CI 0.67-0.84).CONCLUSIONS: Starting lithium treatment early following first psychiatric contact or a single manic/mixed episode is associated with increased probability of lithium response.",
author = "Kessing, {Lars Vedel} and Eleni Vradi and Andersen, {Per Kragh}",
note = "Royal College of Psychiatrists.",
year = "2014",
month = "9",
doi = "10.1192/bjp.bp.113.142802",
language = "English",
volume = "205",
pages = "214--20",
journal = "British Journal of Psychiatry",
issn = "0007-1250",
publisher = "Royal College of Psychiatrists",
number = "3",

}

RIS

TY - JOUR

T1 - Starting lithium prophylaxis early v. late in bipolar disorder

AU - Kessing, Lars Vedel

AU - Vradi, Eleni

AU - Andersen, Per Kragh

N1 - Royal College of Psychiatrists.

PY - 2014/9

Y1 - 2014/9

N2 - BACKGROUND: No study has investigated when preventive treatment with lithium should be initiated in bipolar disorder.AIMS: To compare response rates among patients with bipolar disorder starting treatment with lithium early v. late.METHOD: Nationwide registers were used to identify all patients with a diagnosis of bipolar disorder in psychiatric hospital settings who were prescribed lithium during the period 1995-2012 in Denmark (n = 4714). Lithium responders were defined as patients who, following a stabilisation lithium start-up period of 6 months, continued lithium monotherapy without being admitted to hospital. Early v. late intervention was defined in two ways: (a) start of lithium following first contact; and (b) start of lithium following a diagnosis of a single manic/mixed episode.RESULTS: Regardless of the definition used, patients who started lithium early had significantly decreased rates of non-response to lithium compared with the rate for patients starting lithium later (adjusted analyses: first v. later contact: P<0.0001; hazard ratio (HR) = 0.87, 95% CI 0.76-0.91; single manic/mixed episode v. bipolar disorder: P<0.0001; HR = 0.75, 95% CI 0.67-0.84).CONCLUSIONS: Starting lithium treatment early following first psychiatric contact or a single manic/mixed episode is associated with increased probability of lithium response.

AB - BACKGROUND: No study has investigated when preventive treatment with lithium should be initiated in bipolar disorder.AIMS: To compare response rates among patients with bipolar disorder starting treatment with lithium early v. late.METHOD: Nationwide registers were used to identify all patients with a diagnosis of bipolar disorder in psychiatric hospital settings who were prescribed lithium during the period 1995-2012 in Denmark (n = 4714). Lithium responders were defined as patients who, following a stabilisation lithium start-up period of 6 months, continued lithium monotherapy without being admitted to hospital. Early v. late intervention was defined in two ways: (a) start of lithium following first contact; and (b) start of lithium following a diagnosis of a single manic/mixed episode.RESULTS: Regardless of the definition used, patients who started lithium early had significantly decreased rates of non-response to lithium compared with the rate for patients starting lithium later (adjusted analyses: first v. later contact: P<0.0001; hazard ratio (HR) = 0.87, 95% CI 0.76-0.91; single manic/mixed episode v. bipolar disorder: P<0.0001; HR = 0.75, 95% CI 0.67-0.84).CONCLUSIONS: Starting lithium treatment early following first psychiatric contact or a single manic/mixed episode is associated with increased probability of lithium response.

U2 - 10.1192/bjp.bp.113.142802

DO - 10.1192/bjp.bp.113.142802

M3 - Journal article

VL - 205

SP - 214

EP - 220

JO - British Journal of Psychiatry

JF - British Journal of Psychiatry

SN - 0007-1250

IS - 3

ER -

ID: 135436878