Silver carbene complexes: An emerging class of anticancer agents

Research output: Contribution to journalJournal articleResearchpeer-review

Shravankumar Kankala, Niranjan Thota, Fredrik Björkling, Myles K Taylor, Ravinder Vadde, Ramesh Balusu

Hit, Lead & Candidate Discovery Cancer is a major global health problem with large therapeutic challenges. Although substantial progress has been made in cancer therapy, there still remains a need to develop novel and effective treatment strategies to treat several relapsed and refractory cancers. Recently, there has been growing demand for considering organometallics as antineoplastic agents. This review is focused on a group of organometallics, silver N-heterocyclic carbene complexes (SCCs) and their anticancer efficacy in targeting multiple pathways in various in vitro cancer model systems. However, the precise molecular mechanism of SCCs anticancer properties remains unclear. Here, we discuss the SCCs chemistry, potential molecular targets, possible molecular mechanism of action, and their application in cancer therapies.

Original languageEnglish
JournalDrug Development Research
Volume80
Issue number2
Pages (from-to)188-199
ISSN0272-4391
DOIs
Publication statusPublished - Mar 2019

Bibliographical note

© 2018 Wiley Periodicals, Inc.

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