Short-term administration of glucagon-like peptide-2. Effects on bone mineral density and markers of bone turnover in short-bowel patients with no colon

Research output: Contribution to journalJournal articleResearchpeer-review

K V Haderslev, P B Jeppesen, B Hartmann, J Thulesen, H A Sorensen, J Graff, F Tofteng, S S Poulsen, J L Madsen, J J Holst, M Staun, P B Mortensen, Steen Seier Poulsen

Glucagon-like peptide 2 (GLP-2) is a newly discovered intestinotrophic hormone. We have recently reported that a 5-week GLP-2 treatment improved the intestinal absorptive capacity of short-bowel patients with no colon. Additionally, GLP-2 treatment was associated with changes in body composition that included a significant increase in total body bone mass. This article describes the effect of GLP-2 on spinal and hip bone mineral density (BMD) and biochemical markers of bone turnover in these patients.
Original languageEnglish
JournalScandinavian Journal of Gastroenterology
Volume37
Issue number4
Pages (from-to)392-8
Number of pages7
ISSN0036-5521
Publication statusPublished - 1 Apr 2002

    Research areas

  • Absorptiometry, Photon, Adult, Alkaline Phosphatase, Amino Acids, Bone Density, Bone Diseases, Metabolic, Bone Remodeling, Calcium, Female, Gastrointestinal Hormones, Glucagon, Glucagon-Like Peptide 2, Glucagon-Like Peptides, Hormones, Humans, Intestinal Absorption, Male, Middle Aged, Osteocalcin, Osteoporosis, Parathyroid Hormone, Peptides, Pilot Projects, Short Bowel Syndrome, Vitamin D

ID: 33793088