Self-nanoemulsifying drug delivery systems for oral insulin delivery: In vitro and in vivo evaluations of enteric coating and drug loading

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Standard

Self-nanoemulsifying drug delivery systems for oral insulin delivery : In vitro and in vivo evaluations of enteric coating and drug loading. / Li, Ping; Tan, Angel; Prestidge, Clive A; Nielsen, Hanne Mørck; Müllertz, Anette.

In: International Journal of Pharmaceutics, Vol. 477, No. 1-2, 30.12.2014, p. 390-8.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Li, P, Tan, A, Prestidge, CA, Nielsen, HM & Müllertz, A 2014, 'Self-nanoemulsifying drug delivery systems for oral insulin delivery: In vitro and in vivo evaluations of enteric coating and drug loading', International Journal of Pharmaceutics, vol. 477, no. 1-2, pp. 390-8. https://doi.org/10.1016/j.ijpharm.2014.10.039

APA

Li, P., Tan, A., Prestidge, C. A., Nielsen, H. M., & Müllertz, A. (2014). Self-nanoemulsifying drug delivery systems for oral insulin delivery: In vitro and in vivo evaluations of enteric coating and drug loading. International Journal of Pharmaceutics, 477(1-2), 390-8. https://doi.org/10.1016/j.ijpharm.2014.10.039

Vancouver

Li P, Tan A, Prestidge CA, Nielsen HM, Müllertz A. Self-nanoemulsifying drug delivery systems for oral insulin delivery: In vitro and in vivo evaluations of enteric coating and drug loading. International Journal of Pharmaceutics. 2014 Dec 30;477(1-2):390-8. https://doi.org/10.1016/j.ijpharm.2014.10.039

Author

Li, Ping ; Tan, Angel ; Prestidge, Clive A ; Nielsen, Hanne Mørck ; Müllertz, Anette. / Self-nanoemulsifying drug delivery systems for oral insulin delivery : In vitro and in vivo evaluations of enteric coating and drug loading. In: International Journal of Pharmaceutics. 2014 ; Vol. 477, No. 1-2. pp. 390-8.

Bibtex

@article{64dc13a047ba46f489cec56b0ba4f9a6,
title = "Self-nanoemulsifying drug delivery systems for oral insulin delivery: In vitro and in vivo evaluations of enteric coating and drug loading",
abstract = "This study aims at evaluating the combination of self-nanoemulsifying drug delivery systems (SNEDDS) and enteric-coated capsules as a potential delivery strategy for oral delivery of insulin. The SNEDDS preconcentrates, loaded with insulin-phospholipid complex at different levels (0, 2.5 and 10{\%} w/w), were readily dispersed in water to form nanoemulsions of 35nm and vesicles of 300nm. The association efficiency of non-complexed insulin in the dispersed SNEDDS was 18.6{\%}, and was increased to 73.1{\%} for insulin-phospholipid complex (at 10{\%} loading level). The morphology of the dispersed SNEDDS changed from nanoemulsion droplets to vesicular structures with increasing complex loading levels. A pH-dependent insulin release profile was observed for SNEDDS filled into capsules coated with the enteric polymer, Eudragit({\circledR}) L100. Using a Caco-2 cell model, it was observed that the transport of insulin was enhanced by factors of 7.7- and 9.3- for SNEDDS loaded with 2.5 and 10{\%} complex, respectively. In healthy fasted rats, administration of SNEDDS (10{\%} complex) filled in enteric-coated capsules produced a 2.7-fold and 3.4-fold enhancement in the relative bioavailability and glucose reduction, respectively. This study shows the effectiveness of combining SNEDDS (loaded with insulin-phospholipid complex) with enteric-coated capsules for enhancing the oral absorption and efficacy of insulin.",
author = "Ping Li and Angel Tan and Prestidge, {Clive A} and Nielsen, {Hanne M{\o}rck} and Anette M{\"u}llertz",
note = "Copyright {\circledC} 2014 Elsevier B.V. All rights reserved.",
year = "2014",
month = "12",
day = "30",
doi = "10.1016/j.ijpharm.2014.10.039",
language = "English",
volume = "477",
pages = "390--8",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Self-nanoemulsifying drug delivery systems for oral insulin delivery

T2 - In vitro and in vivo evaluations of enteric coating and drug loading

AU - Li, Ping

AU - Tan, Angel

AU - Prestidge, Clive A

AU - Nielsen, Hanne Mørck

AU - Müllertz, Anette

N1 - Copyright © 2014 Elsevier B.V. All rights reserved.

PY - 2014/12/30

Y1 - 2014/12/30

N2 - This study aims at evaluating the combination of self-nanoemulsifying drug delivery systems (SNEDDS) and enteric-coated capsules as a potential delivery strategy for oral delivery of insulin. The SNEDDS preconcentrates, loaded with insulin-phospholipid complex at different levels (0, 2.5 and 10% w/w), were readily dispersed in water to form nanoemulsions of 35nm and vesicles of 300nm. The association efficiency of non-complexed insulin in the dispersed SNEDDS was 18.6%, and was increased to 73.1% for insulin-phospholipid complex (at 10% loading level). The morphology of the dispersed SNEDDS changed from nanoemulsion droplets to vesicular structures with increasing complex loading levels. A pH-dependent insulin release profile was observed for SNEDDS filled into capsules coated with the enteric polymer, Eudragit(®) L100. Using a Caco-2 cell model, it was observed that the transport of insulin was enhanced by factors of 7.7- and 9.3- for SNEDDS loaded with 2.5 and 10% complex, respectively. In healthy fasted rats, administration of SNEDDS (10% complex) filled in enteric-coated capsules produced a 2.7-fold and 3.4-fold enhancement in the relative bioavailability and glucose reduction, respectively. This study shows the effectiveness of combining SNEDDS (loaded with insulin-phospholipid complex) with enteric-coated capsules for enhancing the oral absorption and efficacy of insulin.

AB - This study aims at evaluating the combination of self-nanoemulsifying drug delivery systems (SNEDDS) and enteric-coated capsules as a potential delivery strategy for oral delivery of insulin. The SNEDDS preconcentrates, loaded with insulin-phospholipid complex at different levels (0, 2.5 and 10% w/w), were readily dispersed in water to form nanoemulsions of 35nm and vesicles of 300nm. The association efficiency of non-complexed insulin in the dispersed SNEDDS was 18.6%, and was increased to 73.1% for insulin-phospholipid complex (at 10% loading level). The morphology of the dispersed SNEDDS changed from nanoemulsion droplets to vesicular structures with increasing complex loading levels. A pH-dependent insulin release profile was observed for SNEDDS filled into capsules coated with the enteric polymer, Eudragit(®) L100. Using a Caco-2 cell model, it was observed that the transport of insulin was enhanced by factors of 7.7- and 9.3- for SNEDDS loaded with 2.5 and 10% complex, respectively. In healthy fasted rats, administration of SNEDDS (10% complex) filled in enteric-coated capsules produced a 2.7-fold and 3.4-fold enhancement in the relative bioavailability and glucose reduction, respectively. This study shows the effectiveness of combining SNEDDS (loaded with insulin-phospholipid complex) with enteric-coated capsules for enhancing the oral absorption and efficacy of insulin.

U2 - 10.1016/j.ijpharm.2014.10.039

DO - 10.1016/j.ijpharm.2014.10.039

M3 - Journal article

VL - 477

SP - 390

EP - 398

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1-2

ER -

ID: 129781476