Rubidium-82 PET imaging is feasible in a rat myocardial infarction model

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Standard

Rubidium-82 PET imaging is feasible in a rat myocardial infarction model. / Ghotbi, Adam Ali; Clemmensen, Andreas; Kyhl, Kasper; Follin, Bjarke; Hasbak, Philip; Engstrøm, Thomas; Ripa, Rasmus Sejersten; Kjaer, Andreas.

In: Journal of Nuclear Cardiology, 2019, p. 1-12.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Ghotbi, AA, Clemmensen, A, Kyhl, K, Follin, B, Hasbak, P, Engstrøm, T, Ripa, RS & Kjaer, A 2019, 'Rubidium-82 PET imaging is feasible in a rat myocardial infarction model', Journal of Nuclear Cardiology, pp. 1-12. https://doi.org/10.1007/s12350-017-0994-9

APA

Ghotbi, A. A., Clemmensen, A., Kyhl, K., Follin, B., Hasbak, P., Engstrøm, T., ... Kjaer, A. (2019). Rubidium-82 PET imaging is feasible in a rat myocardial infarction model. Journal of Nuclear Cardiology, 1-12. https://doi.org/10.1007/s12350-017-0994-9

Vancouver

Ghotbi AA, Clemmensen A, Kyhl K, Follin B, Hasbak P, Engstrøm T et al. Rubidium-82 PET imaging is feasible in a rat myocardial infarction model. Journal of Nuclear Cardiology. 2019;1-12. https://doi.org/10.1007/s12350-017-0994-9

Author

Ghotbi, Adam Ali ; Clemmensen, Andreas ; Kyhl, Kasper ; Follin, Bjarke ; Hasbak, Philip ; Engstrøm, Thomas ; Ripa, Rasmus Sejersten ; Kjaer, Andreas. / Rubidium-82 PET imaging is feasible in a rat myocardial infarction model. In: Journal of Nuclear Cardiology. 2019 ; pp. 1-12.

Bibtex

@article{ea64d23d1c994d89953ab3a3fe85fafa,
title = "Rubidium-82 PET imaging is feasible in a rat myocardial infarction model",
abstract = "Background: Small-animal myocardial infarct models are frequently used in the assessment of new cardioprotective strategies. A validated quantification of perfusion using a non-cyclotron-dependent PET tracer would be of importance in monitoring response to therapy. We tested whether myocardial PET perfusion imaging is feasible with Rubidium-82 ( 82Rb) in a small-animal scanner using a rat myocardial infarct model. Methods: 18 Sprague-Dawley rats underwent permanent coronary artery ligation (infarct group), and 11 rats underwent ischemia-reperfusion (reperfusion group) procedure. 82Rb-PET and magnetic resonance imaging (MRI) were conducted before and after the intervention. Perfusion was compared to both left ventricle ejection fraction (LVEF) and infarct size assessed by MRI. Results: Follow-up global 82Rb-uptake correlated significantly with infarct size (infarct group: r = −0.81, P < 0.001 and reperfusion group: r = −0.61, P = 0.04). Only 82Rb-uptake in the infarct group correlated with LVEF. At follow-up, a higher segmental 82Rb-uptake in the infarct group was associated with better wall motion (β = 0.034, CI [0.028;0.039], P < 0.001, R 2 = 0.30), and inversely associated with scar transmurality (β = −2.4 [−2.6; −2.2], P < 0.001, R 2 = 0.59). The associations were similar for the reperfusion group. Conclusion: 82Rb-PET is feasible in small animal scanners despite the long positron range and enables fast and time-efficient myocardial perfusion imaging in rat models.",
keywords = "infarction, magnetic resonance, perfusion imaging, rat myocardium, rubidium-82 PET, Small-animal heart",
author = "Ghotbi, {Adam Ali} and Andreas Clemmensen and Kasper Kyhl and Bjarke Follin and Philip Hasbak and Thomas Engstr{\o}m and Ripa, {Rasmus Sejersten} and Andreas Kjaer",
year = "2019",
doi = "10.1007/s12350-017-0994-9",
language = "English",
pages = "1--12",
journal = "Journal of Nuclear Cardiology",
issn = "1071-3581",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Rubidium-82 PET imaging is feasible in a rat myocardial infarction model

AU - Ghotbi, Adam Ali

AU - Clemmensen, Andreas

AU - Kyhl, Kasper

AU - Follin, Bjarke

AU - Hasbak, Philip

AU - Engstrøm, Thomas

AU - Ripa, Rasmus Sejersten

AU - Kjaer, Andreas

PY - 2019

Y1 - 2019

N2 - Background: Small-animal myocardial infarct models are frequently used in the assessment of new cardioprotective strategies. A validated quantification of perfusion using a non-cyclotron-dependent PET tracer would be of importance in monitoring response to therapy. We tested whether myocardial PET perfusion imaging is feasible with Rubidium-82 ( 82Rb) in a small-animal scanner using a rat myocardial infarct model. Methods: 18 Sprague-Dawley rats underwent permanent coronary artery ligation (infarct group), and 11 rats underwent ischemia-reperfusion (reperfusion group) procedure. 82Rb-PET and magnetic resonance imaging (MRI) were conducted before and after the intervention. Perfusion was compared to both left ventricle ejection fraction (LVEF) and infarct size assessed by MRI. Results: Follow-up global 82Rb-uptake correlated significantly with infarct size (infarct group: r = −0.81, P < 0.001 and reperfusion group: r = −0.61, P = 0.04). Only 82Rb-uptake in the infarct group correlated with LVEF. At follow-up, a higher segmental 82Rb-uptake in the infarct group was associated with better wall motion (β = 0.034, CI [0.028;0.039], P < 0.001, R 2 = 0.30), and inversely associated with scar transmurality (β = −2.4 [−2.6; −2.2], P < 0.001, R 2 = 0.59). The associations were similar for the reperfusion group. Conclusion: 82Rb-PET is feasible in small animal scanners despite the long positron range and enables fast and time-efficient myocardial perfusion imaging in rat models.

AB - Background: Small-animal myocardial infarct models are frequently used in the assessment of new cardioprotective strategies. A validated quantification of perfusion using a non-cyclotron-dependent PET tracer would be of importance in monitoring response to therapy. We tested whether myocardial PET perfusion imaging is feasible with Rubidium-82 ( 82Rb) in a small-animal scanner using a rat myocardial infarct model. Methods: 18 Sprague-Dawley rats underwent permanent coronary artery ligation (infarct group), and 11 rats underwent ischemia-reperfusion (reperfusion group) procedure. 82Rb-PET and magnetic resonance imaging (MRI) were conducted before and after the intervention. Perfusion was compared to both left ventricle ejection fraction (LVEF) and infarct size assessed by MRI. Results: Follow-up global 82Rb-uptake correlated significantly with infarct size (infarct group: r = −0.81, P < 0.001 and reperfusion group: r = −0.61, P = 0.04). Only 82Rb-uptake in the infarct group correlated with LVEF. At follow-up, a higher segmental 82Rb-uptake in the infarct group was associated with better wall motion (β = 0.034, CI [0.028;0.039], P < 0.001, R 2 = 0.30), and inversely associated with scar transmurality (β = −2.4 [−2.6; −2.2], P < 0.001, R 2 = 0.59). The associations were similar for the reperfusion group. Conclusion: 82Rb-PET is feasible in small animal scanners despite the long positron range and enables fast and time-efficient myocardial perfusion imaging in rat models.

KW - infarction

KW - magnetic resonance

KW - perfusion imaging

KW - rat myocardium

KW - rubidium-82 PET

KW - Small-animal heart

U2 - 10.1007/s12350-017-0994-9

DO - 10.1007/s12350-017-0994-9

M3 - Journal article

SP - 1

EP - 12

JO - Journal of Nuclear Cardiology

JF - Journal of Nuclear Cardiology

SN - 1071-3581

ER -

ID: 184290466