Revisiting biomarker discovery by plasma proteomics

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Philipp E Geyer, Lesca M Holdt, Daniel Teupser, Matthias Mann

Clinical analysis of blood is the most widespread diagnostic procedure in medicine, and blood biomarkers are used to categorize patients and to support treatment decisions. However, existing biomarkers are far from comprehensive and often lack specificity and new ones are being developed at a very slow rate. As described in this review, mass spectrometry (MS)-based proteomics has become a powerful technology in biological research and it is now poised to allow the characterization of the plasma proteome in great depth. Previous "triangular strategies" aimed at discovering single biomarker candidates in small cohorts, followed by classical immunoassays in much larger validation cohorts. We propose a "rectangular" plasma proteome profiling strategy, in which the proteome patterns of large cohorts are correlated with their phenotypes in health and disease. Translating such concepts into clinical practice will require restructuring several aspects of diagnostic decision-making, and we discuss some first steps in this direction.

Original languageEnglish
Article number942
JournalMolecular Systems Biology
Volume13
Issue number9
Number of pages16
ISSN1744-4292
DOIs
Publication statusPublished - 26 Sep 2017

    Research areas

  • Journal Article, Review

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